#H5N1 2.3.4.4b HA E190D and Q226H #mutations, picked up as minority #variants in a #patient, result in an inability to bind #sialic acid.

#H5N1 2.3.4.4b HA E190D and Q226H #mutations, picked up as minority #variants in a #patient, result in an inability to bind #sialic acid, etidiohnew.blogspot.com/2026/03/h5n1...

Sialic acid-responsive Parabacteroides is linked to gut barrier integrity in older adults Aging is frequently accompanied by inflammaging—a chronic, low-grade inflammatory state that contributes to functional decline and disease risk. Disruption of the intestinal barrier is increasingly...

#microsky #glycotime #sialic acid

www.tandfonline.com/doi/full/10....

#Sialic acids are a #barrier to the entry of non-influenza #orthomyxoviruses

#Sialic acids are a #barrier to the entry of non-influenza #orthomyxoviruses, etidiohnew.blogspot.com/2026/01/sial...

Sialidase variability in Gardnerella: genetics, taxonomy, function, and clinical presentation Bacterial vaginosis (BV) is the most common vaginal condition among women of reproductive age. Despite over six decades of research, the pathogenesis and etiology of BV remain largely unknown. Members...

#microsky #glycotime #sialic acid

One of these 3 sialidases is predicted to be intracellular (as seen in other Actinos), hinting at a very intriguing variation on the usual paradigm on Sialoglycan-consumption

www.biorxiv.org/content/10.6...

Unique bifunctional α-sialidase/β-N-acetylgalactosaminidase from Bifidobacterium bifidum acting on the Sda antigen Sda antigens [GalNAcβ1-4(Neu5Acα2-3)Galβ1-O-R] are present at the non-reducing termini of O-glycans of colonic mucins of human. Previously, we reported characterization of two glycoside hydrolase fami...

#microsky #glycotime #glycotimesky #sialic acid

This is fun:

www.jbc.org/article/S002...

It was a pleasure to welcome Ken Kitajima 北島健 again to Vienna (I co-hosted him together with ⁦‪@SMereiter‬⁩).
New insights into sulphation of #sialic acid in mice and fish and degradation of KDN-containing glycoconjugates by bacteria. #glycotime

An RNase III–processed sRNA coordinates sialic acid metabolism of Salmonella enterica during gut colonization | PNAS Sialic acids derived from colonic mucin glycans are crucial nutrients for enteric bacterial pathogens like Salmonella. The uptake and utilization o...

www.pnas.org/doi/10.1073/...

#microsky #sialic acid

STM1128 is a Neu5Ac transporter of the sodium-solute symporter (SSS) superfamily, which @gavinhthomas.bsky.social, Arthur Hosie & I identified 15 years :-)

Sialic acid identity modulates host tropism of sialoglycan-binding viridans group streptococci Microbial interactions with multiple species may expand the range of potential hosts, supporting both pathogen reservoirs and zoonotic spillover. Viridans group streptococci interact with host cells b...

www.jbc.org/article/S002...

#microsky #sialic acid

Interesting story, the starting Q v. important

#Sialic Acid #Receptors in #Human Mammary Tissue: Implications for #Infection with Novel #Influenza Strains

#Sialic Acid #Receptors in #Human Mammary Tissue: Implications for #Infection with Novel #Influenza Strains, etidiohnew.blogspot.com/2025/08/sial...

(3/7) The paper examines how #sialic acids can be attached to three different types of molecules on cell surfaces (#glycoconjugates):
1- N-glycans
2- O-glycans
3- Glycolipids
No one had systematically tested how different IAV strains might differ in their use of these three glycoconjugate types.

On Tue this week I was thrilled to talk at MicroSoc #Microbio25 for the 1st time ever & present some of our work on #sialic acid transporters. Inordinately proud of star 1st author Eunice Lee (who couldn’t attend). Tx, @microbiologysociety.org for the opportunity & the travel grant!