To understand this hidden world, I dug into archival papers about a forgotten disciple of Darwin, visited labs sequencing DNA one cell at a time and spoke with patients whose “mysterious” illnesses suddenly made sense through our new understanding of #somaticmutation.
#MetaplasticBreaseCancer #Proteomics
15 MpBC (6x Spindle 4x Squamous 5x Chondroid) vs 6 TNBC vs 6 normal
MpBC: ⏫EMT ⏬OxPhos
Spindle: MYC/E2F/Ribosome
Squamous: IFNγ/p53/PI3K/Apical junction
Chondroid: EMT OxPhos
+WES #SomaticMutation
#NatureComms 2020
www.nature.com/articles/s41...
STmut
Inferring+Visualizing #SomaticMutation #CopyNumberVariation Germline SNP/#AllelicImbalance in Tumor #SpatialTranscriptomics
#SomaticMutation SNP CNV
sequencing-based ST needed
#GenomeBiology 2023
genomebiology.biomedcentral.com/articles/10....
