Chlorpyrifos induces spermatogenic dysfunction via ferroptosis in Sertoli cells

Chlorpyrifos induces #ferroptosis in #SertoliCells by activating #clockophagy, resulting in the decreased expression of HIF-1α & blood-testis barrier (BTB)-associated proteins, ultimately disrupting integrity & #spermatogenic dysfunction.

#OpenAccess: buff.ly/E70Bs08

Male #infertility affects ~ 7% of men worldwide, but only 1/5 of all cases can be settled by causal #genetic diagnoses. We just filled this gap by identifying a novel cause for severe #spermatogenic defects - M1AP! Read more in our latest #publication:

x.com/AJHGNews/statu…