This study demonstrates that #Chlorpyrifos exposure compromises the #BloodTestisBarrier integrity via #clockophagy-mediated #ferroptosis, leading to abnormal #spermatogenesis. #maleinfertility #sertolicells #medsky

#OpenAccess:
www.sciencedirect.com/science/arti...

Chlorpyrifos induces spermatogenic dysfunction via ferroptosis in Sertoli cells

Chlorpyrifos induces #ferroptosis in #SertoliCells by activating #clockophagy, resulting in the decreased expression of HIF-1α & blood-testis barrier (BTB)-associated proteins, ultimately disrupting integrity & #spermatogenic dysfunction.

#OpenAccess: buff.ly/E70Bs08