Using the classic #globin #superenhancer systems, we discovered two G4 structures in dominant enhancers in both the alpha globin and beta globin locus control systems - and replaced them with non-G4-forming sequences using CRISPR. 2/9

Online now in Stem Cell Reports! FOXO4-SP6 axis controls surface epithelium fate determination by regulating #epigenomic remodeling. #superenhancer #KRT8reporter ow.ly/UZvH50VinfJ

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