We assessed the ability of folate carrier expression in placental cells to predict potential teratogenicity of investigational CNS-active VPA amide derivatives.
doi.org/10.1111/epi....

#epilepsy #epilepsia #ILAE #antiseizuremedications #BeWocells #folatecarriers #pregnancy #teratogenicity

Key point: Prenatal VPA exposure is associated with teratogenicity, rendering it contraindicated for women of childbearing potential.
onlinelibrary.wiley.com/doi/full/10....

#epilepsy #ILAE #epilepsia #neurotoxicity #stemcell #teratogenicity #valproate #VPA

Key point: Intrauterine exposure to antiseizure medication increases the risk of fetal malformation.
doi.org/10.1111/epi....

#epilepsy #ILAE #antiseizuremedication #assistedreproduction #fetalmalformation #heartandgreatvessels #teratogenicity