🧬🔥 Can we stack stabilizing #mutations to #engineer better #enzymes?
Using PROSS-guided design across structural states, researchers create #thermostable tannase variants with up to +6.5 °C Tm and 30% higher kcat
🚀 #protein design #bioengineering
https://ow.ly/bgkp50XW6Of

HyperMPNN ‒ A general strategy to design thermostable proteins learned from hyperthermophiles Stability is a key factor to enable the use of recombinant proteins in therapeutic or biotechnological applications. Deep learning protein design approaches like ProteinMPNN have shown strong performa...

#HyperMPNN - A general strategy to #design thermostable #proteins learned from hyperthermophiles.

Cool stuff! Use this approach to make your favourite protein into #thermostable version!

biorxiv.org/cgi/content/...