📄 Updated UKKA Commentary: Tolvaptan in ADPKD

This work provides clinical context and practical guidance on the use of Tolvaptan for ADPKD, reflecting current evidence, real-world challenges, and expert consensus.

#ADPKD #Tolvaptan #UKKA #RenalMedicine #ClinicalGuidance #KidneyHealth

Long-Term Efficacy of Tolvaptan in ADPKD | Docwire News A study of real-world data found that tolvaptan reduced long-term kidney function decline in autosomal dominant polycystic kidney disease (ADPKD) but did not affect kidney growth.

A study designed examined the long-term effect of #tolvaptan on kidney function and growth in patients with #ADPKD. #nephrology #nephsky #kidneydisease www.docwirenews.com/post/long-te...

Real-world data from 2 US centers show that 27% of ADPKD patients discontinued tolvaptan—10% due to aquaretic side effects. Most stayed on lower doses than in trials. Tolerability remains a major barrier, especially for women. Better strategies needed. #ADPKD #Tolvaptan
10.34067/KID.0000000816

#KidneyFunction Trajectories with #Tolvaptan in #ADPKD Patients with CKD-G5

#VisualAbstract by @thana_susan

www.kireports.org/ar...

💡 Who should get #Tolvaptan in #ADPKD?

A stepwise approach to identifying rapid disease progression 📈

✔️ eGFR decline >3 ml/min/yr? Treat!
✔️ Imaging/genetic risk? Assess!

📊 @BMCNephrology

🔗 doi.org/10.1186/s128...

#Nephrology #Kidney #NephBlueSky

🚨 Tolvaptan = Game changer for #ADPKD, but beware of side effects! 🚨

🧂 Polyuria, thirst, hypernatremia
🩸 Liver toxicity
🤢 GI issues

💡 Risk-benefit discussion is key!

📊 #Tolvaptan S/E frequency @BMCNephrology

🔗 doi.org/10.1186/s128...

#Nephrology

Open-label, Randomized, Controlled, Crossover Trial on the Effect of #Dapagliflozin in Patients with Autosomal Dominant Polycystic Kidney Disease #ADPKD Receiving #Tolvaptan

#VisualAbstract by @md_abdulqader83

www.kireports.org/ar...

Treatment With Tolvaptan Increases Serum Sodium Concentration in Patients With SIAD | Docwire News Tolvaptan increased serum sodium concentration without causing sodium overcorrection in syndrome of inappropriate antidiuresis.

The study examined whether #tolvaptan is more effective than fluid restriction combined with furosemide and sodium chloride tablets for patients with SIAD likely to fail with fluid restriction alone. #kidneywk #nephrology #hyponatremia #nephsky

Day 1: TEMPO 3:4 Trial

🛑 Tolvaptan: Slowing Down PKD Progression
The TEMPO 3:4 Trial changed the game for ADPKD
#Tolvaptan slows kidney volume growth and progression to ESRD.
💡 Takeaway: “ADPKD? Now there’s more than hope—there’s action!”

#ADPKD #Tolvaptan

Prescription of Tolvaptan for Management of Patients With ADPKD | Docwire News A study examined physician confidence and barriers to prescription of tolvaptan for the management of autosomal dominant polycystic kidney disease (ADPKD).

The researchers examined physician confidence and barriers to prescription of #tolvaptan for the management of #ADPKD. #kidneywk #nephrology #kidneydisease #nephsky

Case Report: Patient With Hyponatremia and Fontan-Associated Cardiac Cirrhosis | Docwire News Contrary to recommendations, low-dose tolvaptan may be an option for refractory hyponatremia in cirrhosis.

Researchers determined that #tolvaptan should be considered as an alternative therapy for refractory #hyponatremia in cirrhosis. #kidneywk #nephsky

Tolvaptan for Treatment of Patients With ADPKD in the Republic of Korea Safe and Effective | Docwire News ESSENTIAL assessed the safety and effectiveness of tolvaptan among patients in Korea with autosomal dominant polycystic kidney disease (ADPKD) and CKD stages 1 to 3.

ESSENTIAL evaluated the safety and efficacy of the selective vasopressin V2 receptor antagonist #tolvaptan in patients with #ADPKD and #CKD stages 1 to 3. #kidneywk #kidneydisease #nephsky

@ecorneclegall New trials in #apkd including #metformin v #tolvaptan #metropolis study #diabetes #drugs might change the game once again for #nephrologists @P_Rossing @drjamesboyle @ga_mckay @medupdateeurope #nephroeurope19

No #apkd talk complete without mention of #tolvaptan @ecorneclegall @ynptweets @ERAEDTA @medupdateeurope #nephroeurope19

#tolvaptan and #urea cancer

#askrenal Patient with ADPKD, already had liver transplant for polycystic liver disease. High risk for progression based on kidney size. Has pain. #Jynarque (#tolvaptan?) Or is a stable liver txp a deal breaker?

Has anyone trademarked #DIDI (drug induced diabetes insipidus) as the term for polyuria from the use of #Tolvaptan for #ADPKD

If not dibs!