3D reconstructions of local synaptic connectivity in hippocampal CA1 pyramidal neurons obtained by volume electron microscopy. Dendritic segments (gray) are shown either alone or with their innervating axons in a wild-type mouse (left) and in a Cyfip2+/R87C knock-in mouse model of West syndrome (right). Yellow puncta indicate postsynaptic densities. Compared with wild-type neurons, knock-in neurons exhibit markedly reduced dendritic spines, with excitatory synapses forming directly on dendritic shafts and showing dense clustering of presynaptic axon terminals. Scale bar, 1 µm. Image credit: Kea Joo Lee and Gyu Hyun Kim.

#WestSyndrome is a severe neurodevelopmental disorder. This study provides a longitudinal picture of glial activation, synaptic remodeling & #LipidMetabolism in a mouse model of West syndrome, uncovering cellular & molecular mechanisms linked to #seizure evolution @plosbiology.org 🧪 plos.io/48tgUkv

3D reconstructions of local synaptic connectivity in hippocampal CA1 pyramidal neurons obtained by volume electron microscopy. Dendritic segments (gray) are shown either alone or with their innervating axons in a wild-type mouse (left) and in a Cyfip2+/R87C knock-in mouse model of West syndrome (right). Yellow puncta indicate postsynaptic densities. Compared with wild-type neurons, knock-in neurons exhibit markedly reduced dendritic spines, with excitatory synapses forming directly on dendritic shafts and showing dense clustering of presynaptic axon terminals. Scale bar, 1 µm. Image credit: Kea Joo Lee and Gyu Hyun Kim.

#WestSyndrome is a severe neurodevelopmental disorder. This study provides a longitudinal picture of glial activation, synaptic remodeling & #LipidMetabolism in a mouse model of West syndrome, uncovering cellular & molecular mechanisms linked to #seizure evolution @plosbiology.org 🧪 plos.io/48tgUkv

3D reconstructions of local synaptic connectivity in hippocampal CA1 pyramidal neurons obtained by volume electron microscopy. Dendritic segments (gray) are shown either alone or with their innervating axons in a wild-type mouse (left) and in a Cyfip2+/R87C knock-in mouse model of West syndrome (right). Yellow puncta indicate postsynaptic densities. Compared with wild-type neurons, knock-in neurons exhibit markedly reduced dendritic spines, with excitatory synapses forming directly on dendritic shafts and showing dense clustering of presynaptic axon terminals. Scale bar, 1 µm. Image credit: Kea Joo Lee and Gyu Hyun Kim.

#WestSyndrome is a severe neurodevelopmental disorder. This study provides a longitudinal picture of glial activation, synaptic remodeling & #LipidMetabolism in a mouse model of West syndrome, uncovering cellular & molecular mechanisms linked to #seizure evolution @plosbiology.org 🧪 plos.io/48tgUkv

Key point: We hypothesized that the time course of the BASED score after ES remission is associated with ES relapse.
doi.org/10.1111/epi....

#epilepsy #ilae #antiseizuremedication #electroencephalography #hypsarrhythmia #interraterreliability #Westsyndrome

Key point: Thalamic electroencephalography (EEG) showed slow-wave complex with or without low-voltage fast activity during epileptic spasms.
onlinelibrary.wiley.com/doi/full/10....

#epilepsy #ILAE #corticothalamicnetwork #infantileepilepticspasmssyndrome #thalamus #westsyndrome

Key point: Racial disparities: Non-Hispanic Black children with IESS had significantly lower odds of undergoing genetic sequencing.
doi.org/10.1002/epi4...

#epilepsy #ILAE #geneticsequencing #healthequity #inequities #infantilespasms #westsyndrome