Swedish Medical Birth Register study of pregnancy in systemic sclerosis (SSc) shows increased risk of preeclampsia (RR 3.8; 1.8-7.8), preterm birth (3.3; 1.8-6.1), & caesareans (2.5; 1.8-3.5) esp w/ 1st pregnancy acrjournals.onlinelibrary.wiley.com/doi/10.1002/...

Exposure during pregnancy to Il-1 targeted therapies and pregnancy, fetal and neonatal outcomes: a study from the French Teratology Information Service AbstractOBJECTIVE. To describe the outcomes of pregnancies exposed to IL-1 targeted therapies (anti-IL-1): anakinra and/or canakinumab.METHODS. We performe

Also great to see further reassuring data for anakinra in pregnancy, now out from France academic.oup.com/rheumatology...

Platelets as drivers of immunothrombosis in rheumatic diseases Nature Reviews Rheumatology, Published online: 07 July 2025; doi:10.1038/s41584-025-01276-zThis Review provides an overview of how platelets promote immunothrombosis in rheumatic disease. The authors discuss the different ways in which platelets and immunothrombosis can be targeted for therapeutic intervention.

New content online:

ℹ️ Mise au point
Quelle place de la protéine ADAMTS13 recombinante humaine dans le traitement du purpura thrombotique thrombocytopénique ? Retrouvez les recommendations du CNR des microangiopathies thrombotiques sur les indications et modalités d’administration👇

www.sciencedirect.com/science/arti...

The pathogenesis, clinical presentations and treatment of monogenic systemic vasculitis Nature Reviews Rheumatology - This Review discusses the clinical features, pathogenesis, diagnosis and management of monogenic forms of vasculitis. The authors emphasize that increased awareness of...

✨July Issue✨| Monogenic systemic vasculitis

In this Review, the authors discuss the pathogenesis, clinical presentations and treatment of monogenic systemic vasculitis.

Free to read: bit.ly/3I0cw14 🔓

#Rheumsky #Medsky

Le 90ème Congrès #SNFMI débute demain à #Vichy
snfmivichy2025.com

Découvrez d'ores et déjà l'ensemble des résumés de Communications dans notre Numéro spécial Congrès : www.sciencedirect.com/journal/la-r...

French protocol for diagnosis and management of type 1 interferonopathies

www.sciencedirect.com/science/arti...

Loss of TRIM21 drives UVB‐induced systemic inflammation by regulating DNA‐sensing pathways Background Patients with systemic lupus erythematosus (SLE) experience photosensitivity, with exposure to ultraviolet light B (UVB) driving lupus flares and triggering symptoms like joint pain, fati...

Inflammatory response to UVB exposure in Trim21-/- mice
doi.org/10.1002/art....

Open-label trial of escalation to golimumab in early axSpA gut inflammation
doi.org/10.1002/art....

Our July issue is live!

Including research on patient-reported outcomes in #SLE, #SystemicSclerosis associated #ILD, autoimmune diseases during #pregnancy, and treatment outcomes in #VEXAS syndrome, plus much more! www.thelancet.com/journals/lan...
Cover by Sara Gironi Carnevale #Medsky #Rheumsky

The clinical responses in Patients 1 and 2 before and after the first dose of CM336 through 6 months.

Two patients had autoimmune hemolytic anemia that relapsed after CD19 CAR T-cell therapy but responded rapidly to BCMA-targeted T-cell–engager therapy with remission, minimal side effects, and hematologic improvement. Learn more: nej.md/3SM6S4V

#MedSky #Immunology

NEW RESEARCH—Exposure to #hydroxychloroquine in early #pregnancy and incidence of pre-eclampsia and pre-term delivery in patients with systemic #lupus erythematosus in Sweden: a nationwide population-based cohort study bit.ly/3FBPz3J @rheumepi.bsky.social

Plus, linked Comment bit.ly/3Tknh0D

NEW RESEARCH—Trends in the prevalence of autoimmune diseases during #pregnancy in the UK, 2000–21: a retrospective cohort study bit.ly/449fPe3 #Medsky #Rheumsky

Plus linked Comment by @hilarykbrown.bsky.social & @nataliescime.bsky.social bit.ly/3HrIPps

Advances in the treatment of ANCA-associated vasculitis Nature Reviews Rheumatology, Published online: 05 June 2025; doi:10.1038/s41584-025-01266-1This Review discusses the advances and challenges of managing antineutrophil cytoplasmic antibody-associated vasculitis. The authors discuss current treatment options, emerging therapies and unmet needs in the management of this disease.

New content online:

Late breaking at #ASCO25:

A 3-year structured exercise program after adjuvant chemotherapy for colon cancer improved disease-free and overall survival, physical functioning, and fitness, as compared with health education alone. Full CHALLENGE phase 3 trial: nej.md/4mh5RPL

@ascocancer.bsky.social

NEW RESEARCH for #LUPUS2025 —Maternal autoantibodies to the sodium potassium pump α1 subunit AT1A1 and fetal autoimmune congenital heart block: a case-control study bit.ly/43lRzol

Plus, linked Comment bit.ly/3STJLoV
#Medsky #Rheumsky

Portrait du Pr Alexandre Belot, PU-PH en rhumatologie pédiatrique au CHU de Lyon, co-coordinateur de la filière FAI2R

🖼️Portrait
Découvrez Alexandre Belot, PUPH en rhumatologie pédiatrique et co-coordinateur de la filière FAI2R, ainsi que son regard sur la médecine interne et son avenir.

www.sciencedirect.com/science/arti...

Vaccination in pregnancy to protect the newborn - Nature Reviews Immunology In this Review, Male and Jones provide an overview of the current vaccines that are offered during pregnancy and to newborns, explaining the rationale behind the different vaccination programmes and the unique challenges that come with immunizing these populations.

A Review in Nature Reviews Immunology provides an overview of the current vaccines that are offered during pregnancy and to newborns, explaining the rationale behind the different vaccination programmes and the unique challenges that come with immunizing these populations. 🔒

🔬Du 12 au 17 mai, @ap-hp.bsky.social célèbre celles et ceux qui font avancer la recherche pour améliorer les soins et donner de l’espoir aux patients. #recherche #recherchemedicale #rhumatologie #spondyloarthritis #spondyloarthrite

🤔Missed any #RheumaPreg25 sessions?
No worries! Join the highlights webinar on May 26. Contact @karenschreiber.bsky.social or @lauraandreoli.bsky.social to join the #ReHFaP mailing list 📩

« Faut-il traiter le lymphome du MALT dans la maladie de Sjögren ? » : le pour

⚖️ Faut il traiter le lymphome du MALT dans la maladie de Sjögren?

✅Pour?
www.sciencedirect.com/science/arti...

🚫Contre?
www.sciencedirect.com/science/arti...

La « Controverse », l’heure du staff dans la revue de médecine interne

⚖️ Inauguration de la rubrique « Controverse » ce mois ci dans la Revue de Médecine Interne

www.sciencedirect.com/science/arti...

A schematic representation of clonal hematopoiesis of indeterminate potential (CHIP) and tumor-infiltrating clonal hematopoiesis (TI-CH) in a patient with lung cancer.

Both clonal hematopoiesis of indeterminate potential (CHIP) and cancer are more common with age. When they coexist in the same patient, CHIP cells may migrate to the tumor and have an adverse effect on overall survival. Full study results: nej.md/3EnzMVu

#MedSky #Hematology

Blood pressure reduction and all-cause dementia in people with uncontrolled hypertension: an open-label, blinded-endpoint, cluster-randomized trial - Nature Medicine In the CRHCP-3 cluster-randomized trial, blood pressure reduction lowered the risk of all-cause dementia by 15% in 33,995 individuals with hypertension.

Reducing the risk of all-cause dementia with intensive blood pressure control, the results of a cluster randomized trial in~34,000 participants. @naturemedicine.bsky.social
www.nature.com/articles/s41...

Time-dependent effect of prophylactic trimethoprim-sulfamethoxazole on the incidence of serious infections in ANCA-associated vasculitis: A target trial emulation study. Graphical abstract created with BioRender

Multicenter cohort trial emulation tested TMP-SMX prophylaxis on incidence of serious infections in pts w/ ANCA-associated vasculitis. TMP-SMX significantly reduced risk of serious infections, esp. during 1st 6 mo. of induction therapy w/ RTX or CYC

A&R
doi.org/10.1002/art....
#Medsky #Rheum #IDsky

The New England Journal of Medicine Efficacy and Safety of Obinutuzumab in Active Lupus Nephritis A Research Summary based on Furie RA et al. | 10.1056/NEJMoa2410965 | Published on February 7, 2025 Visual representations of the patients in the trial and the treatments they were assigned. Read the full Research Summary at NEJM.org.

In the REGENCY phase 3 trial, obinutuzumab, a humanized type II anti-CD20 monoclonal antibody, plus standard therapy provided significantly better renal responses than standard therapy alone in patients with lupus nephritis. Full trial results and Research Summary: nej.md/3Eq6gxV

#MedSky

Human papillomavirus et lupus systémique : une revue systématique
www.sciencedirect.com/science/arti...
#SLE #HPV

Why and how academic medicine must champion diversity, equity, inclusion, and accessibility US President Donald Trump has launched a series of Executive Actions1 to dismantle diversity, equity, inclusion, and accessibility efforts; defund scientific research; and freeze federal funds and pro...

“Even though individuals might feel powerless, we all have our own spheres of influence” 🌐

A Comment in The Lancet on why and *how* academic medicine must champion diversity, equity, inclusion, and accessibility 👉 bit.ly/4cwIBZL

Temporal trends in glucocorticoids and hydroxychloroquine for treatment of systemic lupus erythematosus in Sweden AbstractObjectives. It is unknown to what extent updated treatment recommendations regarding glucocorticoids (GC) and hydroxychloroquine (HCQ) for patients

Here is our latest on treatments in lupus. We studied glucocorticoids (GC) and hydroxychloroquine (HCQ) trends over time in patients with lupus in Sweden 2005-2021. The treatment guidelines have changed over time and aim for more HCQ and less GC (lower doses). academic.oup.com/rheumatology...

Figure showing the endocrine organs affected by immune-related adverse events, with lists of the main effects.

In this Review from our May issue, Shintaro Iwama, Tomoko Kobayashi & Hiroshi Arima discuss the management, biomarkers and prognosis in people developing #endocrinopathies associated with #immune checkpoint inhibitors (£) go.nature.com/43TbTQ2 #EndoSky