OK Kids, our ERK story is finally heading out into the world. After 9 years of having funding, losing funding, losing staff, getting funding, gaining staff...it's ready!
We discovered a novel stage of what is an otherwise extensively studied process: how cells respond to extracellular signals. 1/n
🧵 CTCF is essential for embryonic development, but why has remained unclear. By combining gastruloids with a temporal degron system, we uncovered a surprising dual function — and it changes how we think about CTCF's role in development. 1/8 www.biorxiv.org/content/10.6...
Do you want to understand how RNA #splicing decisions are made? We‘ve got a PhD position open for you (see 👇👇)!!
Please share #RNAsky and RT!
tinyurl.com/4ztu9cb9
Yes! Do you feel like coming over for a seminar here and chatting? (probably can coordinate more offline :))
Very brief scientific background: I am particularly interested in the mechanisms behind early transcription termination. Approaches we often use include CRISPR screens and nascent RNA sequencing after rapid depletions. Bringing your own project ideas and expertise is also encouraged!
I am offering a fully-funded position for 3 years (evaluation after 1y). We're located in lovely Utrecht, and embedded in a wonderful research environment. More information and apply button here: www.uu.nl/en/organisat...
Please apply or share if the position suits you / you know someone suitable!
The Vlaming lab continues to grow!
It's an exciting time in the Vlaming lab: we've just had our 2nd PhD student join, and the 3rd is joining in February. Now, we're looking to recruit a postdoc!
Congratulations, looks fascinating!
👏👏👏 Congrats Chris, looking forward to reading!
And for you!! Congratulations!
There have now been at least 3 starting grants earned by participants of that one Epigenetics course in Paris in 2011, with maybe 20-25 participants? Pretty impressive!
Getting this grant took several attempts and lots of support from my past advisors, current colleagues and many other science friends. Thank you to everyone who helped me prepare by proofreading, doing practice talks or sharing advice or encouragement!!
As part of this grant, I have a vacancy out for a PhD student to join our super nice team. It closes on September 9 (Tuesday).
If you are or know a good prospective PhD student, excited about studying transcription, please (suggest them to) apply here: www.uu.nl/en/organisat...
Thrilled to be one of the ERC StG awardees this year! It will allow my team to further delve into the puzzle of what regulates the fate of RNA Polymerase II during early elongation: will it terminate early, or elongate happily ever after?
Very proud of our paper on "scrambling-by-hopping" LADs, which was just published: www.nature.com/articles/s41.... Congrats to Lise Dauban and the rest of the team – this was a real tour-de-force!
Fragile Nucleosome Fall Seminars: September 10 Grace Bower, Kvon Lab @ UC Irvine, USA Jennifer Phillips-Cremins, UPenn, USA September 24 Ali Wilkening, Sanulli Lab @ Stanford, USA Juanma Schvartzman, Columbia University, USA October 8 Sanim Rahman, Greenberg Lab @ UPenn, USA Alex Federation, Talus Bio, USA October 22 Alice Laigle, Croll Lab @ University of Neuchâtel, Switzerland Seungsoo Kim, UC Irvine, USA November 5 Hannah Long, University of Edinburgh, UK Jeff Vierstra, Altius Institute, USA November 19 Ishtiaque Hossain, Pastor Lab @ McGill, Canada Sarah Teichmann, University of Cambridge, UK December 3 María Mariner Faulí, Rada Iglesias Lab @ IBBTEC, Spain Jonathan Henninger, Carnegie Mellon, USA December 17 Rebecca Berrens, Oxford University, UK Jean-Benoit Lalanne, University of Montreal, Canada
We're super excited to announce the entire lineup for the Fall season of Fragile Nucleosome Seminars, starting on Sept 10th at 1200 EDT / 1600 UTC with @gracebower.bsky.social and @creminslab.bsky.social!
register here for the entire series: us06web.zoom.us/webinar/regi...
🧬 Transcription elongation by RNA polymerase II relies on a web of elongation factors. Our new work shows how IWS1 acts as a modular scaffold to stabilize & stimulate elongation. Fantastic work by Della Syau! www.biorxiv.org/content/10.1...
Could you add me too? Thanks!
Activity of most genes is controlled by multiple enhancers, but is there activation coordinated? We leveraged Nanopore to identify a specific set of elements that are simultaneously accessible on the same DNA molecules and are coordinated in their activation. www.biorxiv.org/content/10.1...
The Vlaming lab is expanding! If you are or know a good prospective PhD student, excited about studying transcription, please (suggest them to) apply here: www.uu.nl/en/organisat...
My biased opinion: exciting topic, super nice colleagues, and great research environment in a lovely city.
🚨 New preprint from our labs (STOP lab @stoplab.bsky.social & Nojima lab @pol2rna.bsky.social @pyrolyn.bsky.social)! We've been digging into how chromatin remodeler SETD2 controls the start and end of transcription 👇 www.biorxiv.org/cgi/content/... (1/5)
A transcription balance required for genome stability 🧬⚖️
Our work on RNA Pol II transcription speed control by the DNA helicase RECQL5 and the transcription-coupled DNA repair complex is now on @natsmb.nature.com
#CryoEM #transcription #genomestability
www.nature.com/articles/s41...
Excited to share our latest work! We found transcription factor SPT6 and phosphorylated Pol II CTD help recruit U1 snRNP to elongating Pol II, allowing efficient co-transcriptional splicing.
Glad to be featured in the Editors’ Highlights!
www.nature.com/articles/s41...
#splicing #cryoEM
Big thank you to co-lead @camimoso.bsky.social and to @adelmanlab.bsky.social. Further support from Nathalie in my group (first paper with @utrechtuniversity.bsky.social affiliation 🤩!) and Allison.
This manuscript was a long time in the making (started while Claudia and I were both still in the Adelman lab), but thankfully going from preprint to published in @genesdev.bsky.social was a smooth process!
Happy to share this paper! We uncovered that good 5' splice sites protect against ZC3H4/Restrictor's promiscuous role, and that its role is to suppress elongation and indirectly cause termination. Looking forward to learning more about this protein in the future!
Finally joined this platform! Looking forward to reconnect with many old friends and colleagues, and connect with new people too! Now let's see if I can moderate my 'intake', haha.
