Impressive research!!! Cells sometimes uses filamentous form to store critical enzymes?

1) The Herzik lab is excited to announce our newest preprint in collaboration with the Grotjahn lab! We have developed a surfactant cocktail that seeks to overcome one of the more nefarious problems in #cryoEM, Air-water interface (AWI)-induced damage and preferred orientation (PO).

おめでとうございます。素晴らしい研究室を運営されているようですね。皆さんの笑顔が素敵です！

Looking forward to the guest lecture of Prof. Nikolaus Grigorieff from the University of Massachusetts about “Extending the scope of single-particle cryo-EM using 2D template matching” on March 23 at 12:30 in seminar room N100/114. Remote access: uni-frankfurt.zoom.us/meeting/regi...

We're excited to announce the beta-release of #RELION-5.1! 🥳 This release has important updates on our #amyloid processing pipeline, as described in this preprint: doi.org/10.64898/202... There are also some tweaks for #teamtomo.

#OpenSoftwareAcceleratesScience

Sounds good, but, we also consider suitable area for high-resolution Cryo-ET.

Figure 1. Cryo-EM of abundant protein complexes in native membranes.

Figure 2. Cryo-EM of membrane proteins in vesicles.

Figure 3. 3D reconstruction of V-ATPase in native synaptic vesicle membranes.

Figure 4. Generation of membrane vesicles for structure determination of proteins in their native lipid bilayer.

I've written a review on what I think is an extremely exciting direction in cryo-EM:

Cryo-EM of endogenous membrane proteins in their native lipid bilayer

Open access in Quarterly Reviews of Biophysics:
doi.org/10.1017/S003...

Deltaviruses spread through a viral Trojan Horse Hepatitis D-like satellite viruses, known as deltaviruses, have been recently discovered in a wide range of animals. These viruses are thought to expr…

We found a viral Trojan Horse: a virus can hide inside another virus.This one surprised us: deltaviruses don’t just borrow a helper virus. They can travel inside it.
A literal Trojan Horse “virus-in-a-virus” route into cells. 🤯 Kudos to 1st author @viroscope.bsky.social and co-authors !

A research team from the Max Planck Institute for Multidisciplinary Sciences, the Institut Pasteur, and EMBL has shown in a Nature paper how the influenza polymerase, a molecular thief, uses the host RNA to replicate.

Check out the MPI press release: www.mpinat.mpg.de/5179649/pr_2...

Apply now! @vbcscitraining.bsky.social offers more than 25 fully-funded PhD positions! GMI group leaders are also recruiting new students.

𝗘𝘅𝗰𝗶𝘁𝗶𝗻𝗴 𝗗𝗲𝘃𝗲𝗹𝗼𝗽𝗺𝗲𝗻𝘁𝘀 𝗶𝗻 𝗠𝗶𝗰𝗿𝗼𝘀𝗰𝗼𝗽𝘆 𝗥𝗲𝗽𝗼𝗿𝘁𝗶𝗻𝗴! If you're involved in creating, processing, or publishing microscopy data, take a look at the new checklist for reporting requirements provided by @quarep-limi.bsky.social in @jcb.org 🔗 rupress.org/jcb/article/...

Structure-guided design of a PfCyRPA-based vaccine against blood-stage malaria - EMBO Molecular Medicine Effective vaccines against malaria are urgently required. All components of the PfPCRCR complex are essential for erythrocyte invasion by Plasmodium falciparum and are potential vaccine immunogens aga...

This immunogen is cheap and easy to produce and elicits a high quality antibody response. Project led by @nawsadalam. Read all about it:
link.springer.com/article/10.1...

Mapping the yeast atructural interactome with AlphaFold3: an open call for collaboration We are excited to announce the early-stage release of our S. cerevisiae  structural interactome mapping project. Using AlphaFold3 (AF3), w...

We have started a project trying to predic the interactions/structures of all yeast protein pairs using an AlphaFold pooling approach. We are making the current dataset open and we welcome collaborations.
www.evocellnet.com/2026/03/mapp...

The new Vienna BioCenter Interdisciplinary Postdoctoral Program (VIP³) is here! We have 8 fully-funded positions for scientists with a PhD in biology, chemistry, physics, bioinformatics etc.

The call is open!

More information: training.vbc.ac.at/post-docs/vi...

#VBCPostDoc

High-resolution in situ structures of hantavirus glycoprotein tetramers The cryo-EM structures of Andes hantavirus (ANDV) glycoprotein tetramers, dimers of tetramers, and ADI-65534 Fab complexes on eVLPs unveil the molecular basis of New World hantavirus glycoprotein architecture, acid-induced membrane fusion, and antibody-mediated neutralization. Immunization with repRNA encoding ANDV-VLPs elicits high neutralizing-antibody titers.

Now online! High-resolution in situ structures of hantavirus glycoprotein tetramers

ChimeraX screenshot showing CubeNTube plugin.

The new ChimeraX CubeNTube plugin allows erasing parts of maps using cube, cylinder, and custom shapes and has undo. Created by Tamino Cairoli. Available from ChimeraX menu Tools / More Tools....

New insights uncovered into crystal-like structure of proteasomes in membrane-less organelles A new study from a team of Canadian and German researchers has uncovered never-before-seen details about what happens to proteasomes, the cell’s garbage disposal system, when there is not enough…

Study from a team of Canadian and German researchers has uncovered never-before-seen details about what happens to proteasomes, the cell’s garbage disposal system, when there is not enough energy. bit.ly/3OGywRX

The (microbe) highway to the danger zone LJI Professor Mitchell Kronenberg shows how immune cells defend your most vulnerable organs. His discoveries recently earned top recognition from the American Academy of Microbiology.

Your airways and your gut are high-traffic areas for the microbes of the world. 🦠

For more than 40 years, LJI's Mitchell Kronenberg has studied the T cells that step up to defend our most vulnerable organs.

Now Kronenberg has been elected fellow of the AAM: bit.ly/4rBrcps

@asm.org #microbiology

“Compared to the reduction at the national level, the large declines in cervical cancer incidence observed in several states were very encouraging"

Cancer rates decreased in states with the highest HPV vaccination rates - #MedSky + #OncSky + #ReproSky.

pressroom.cancer.org/declines-in-...

Nice #alphafold

Tried it. Its awesome. Shame the code isn't available. Webserver only, how long will it last??

Long in the making, but happy to present the Chlamydomonas chlororibosome!
Cryo-ET🔬reveals a large new domain on the small subunit, built from multiple extensions in conserved ribosomal proteins.
bioRxiv 📖: shorturl.at/q44tG
This suggests greater chlororibosome diversity than expected!
1/n 🧵

GitHub - GrotjahnLab/surface_morphometrics: Morphometrics for Membrane Surfaces Segmented from Cryo-ET or other volumetric imaging. Morphometrics for Membrane Surfaces Segmented from Cryo-ET or other volumetric imaging. - GrotjahnLab/surface_morphometrics

I've been working on Surface Morphometrics for a new version (coming soon), and made some significant (AI-assisted) performance improvements, especially in pycurv (20-50x!). If you've had technical issues or just felt like it was too slow, give it another try! #teamtomo github.com/GrotjahnLab/...

🚀 CryoSPARC v5.0 BETA is here!

We’re excited to deploy another major #CryoSPARC release to help enable and accelerate #cryoEM data analysis. v5 has a redesigned underlying software system and many new features - highlights in thread!

Full changelog: cryosparc.com/updates/v5.0.0

We are running the cryo-ET image processing workshop again this year! Come learn everything tomo: STA, segmentation, heterogeneity analysis from @baradlab.com @williamnwan.bsky.social and others!

Apply!

A super detailed protocol + video on Cryo-ExM - Cryo-Expansion Microscopy, led by the labs of our former postdocs @marinelap.bsky.social & @ebertiaux.bsky.social.
Clear, practical, and very useful for anyone doing nanoscale imaging 🚀 app.jove.com/t/68595/expa...

Recruitment for the EMBL International PhD Programme is officially open! 🔊

At EMBL, we train young scientists to become skilled and creative future leaders in academia, industry and other sectors. Start your career in the life sciences with us!

🔎 Read more here:
tinyurl.com/4jdt2ra5

SHAPES being the key word, amirite @nanigrotjahn.bsky.social
github.com/GrotjahnLab/...

Should be an interesting #TeamTomo talk. Check it out! 🧪 🔬

When two years of academic work vanished with a single click After turning off ChatGPT’s ‘data consent’ option, Marcel Bucher lost the work behind grant applications, teaching materials and publication drafts. Here’s what happened next.

Everyone should read this!

🧪 #AcademicSky

When two years of academic work vanished with a single click

www.nature.com/articles/d41...

Mechanism of membrane perforation in rotavirus cell entry www.biorxiv.org/content/10.64898/2026.01.21.700916v1 #cryoEM