Gracias a la @cadenaser.com por su reportaje sobre #Alergia alimentaria y sobre nuestro estudio en @cp-cellhostmicrobe.bsky.social donde mostramos que las #bacterias #orales pueden degradar #alergenos, modulando su reconocimiento por #IgE y la #anafilaxia.

(min 48:30)
cadenaser.com/audio/cadena...

Microbes that chew allergens mitigate anaphylaxis In the current issue of Cell Host & Microbe, Sánchez-Martínez et al. demonstrate that oral and small-intestine bacteria can modulate IgE-mediated anaphylaxis through metabolic degradation of immunodominant peanut allergens. This study provides insights into microbial mechanisms underlying food-induced anaphylaxis and may point to new directions for advancing food allergy therapy.

Microbes that chew allergens mitigate anaphylaxis

Preview of work demonstrating that oral & small intestinal bacteria can modulate IgE-mediated anaphylaxis through metabolic degradation of immunodominant peanut allergens.
www.cell.com/cell-host-mi...

Microbes impact peanut allergy

Mouth & gut contain peanut-degrading bacteria(Rothia) that metabolize PN allergens. Mice colonized w/Rothia show decreased anaphylaxis & allergic patients w/better PN tolerance have higher abundance of these bacteria
www.cell.com/cell-host-mi...

Our April issue is now live!
On the cover: Peanut allergy & microbes

Bacteria in the oral cavity & small intestine can degrade immunodominant peanut allergens, limiting anaphylaxis
www.cell.com/cell-host-mi...

Bacterial allies against food anaphylaxis Nature Reviews Microbiology, Published online: 20 March 2026; doi:10.1038/s41579-026-01300-3This study shows that some human microbiota bacteria can metabolize immunodominant peanut allergens, thus modulating IgE-mediated anaphylaxis.

New online! Bacterial allies against food anaphylaxis

a woman looks through a microscope in a lab ALT: a woman looks through a microscope in a lab

Un recuerdo hoy (y todos los días) para todas las mujeres investigadoras, en el #DiaInternacionalDeLaMujer #8M seguimos implicados todos/as para conseguir la tan deseada igualdad entre hombres y mujeres lo antes posible.
Ya vamos tarde. 💜
@cnb-csic.bsky.social @sebbm.bsky.social @csic.es @uam.es

Peanut-processing microbes ward off dangerous allergic shock Scientists identify bacteria that digest allergy-triggering compounds in peanuts, which can be life-threatening to those with allergies.

#Peanut-processing #microbes ward off dangerous #allergic #shock www.nature.com/articles/d41...

IgE-dependent anaphylaxis is regulated by sphingolipid binding to activating and inhibitory CD300 family members Izawa et al. identify sphingomyelin and ceramide species as ligands for CD300d3 and CD300f. CD300d3 enhances IgE-mediated murine mast cell activation via its ligands, whereas CD300f inhibits it. Mast ...

IgE-dependent anaphylaxis is regulated by sphingolipid binding to activating and inhibitory CD300 family members @cp-cellreports.bsky.social www.cell.com/cell-reports...

Your microbiome may determine your risk of a severe allergic reaction The microbes that live in our mouth and gut may influence whether an allergic reaction to peanuts is mild or life-threatening, and could be harnessed to ward off a severe attack

The microbes that live in our mouth and gut may influence whether an allergic reaction to peanuts is mild or life-threatening, and could be harnessed to ward off a severe attack

Microbial metabolism of food allergens determines the severity of IgE-mediated anaphylaxis Sánchez-Martínez and Rondeau et al. reveal that human oral microbes degrade peanut allergens, thereby reducing IgE recognition, systemic availability, mast cell activation, and anaphylaxis. This study...

Microbiota impact peanut allergy

Saliva & jejunum harbor peanut-degrading bacteria(Rothia) that metabolize immunodominant PN allergens. Mice colonized w/Rothia show ⬇️anaphylaxis & allergic patients w/better PN tolerance have ⬆️abundance of these bacteria
www.cell.com/cell-host-mi...

Delighted to share our new #preprint on #mastcell desensitization on @biorxiv-immuno.bsky.social

We show that #mastcell #desensitization involves #IgE internalization and induces distinct #immunoregulatory #transcriptional program linked to #immune regulation.

www.biorxiv.org/content/10.6...

Mast cell desensitization induces a distinct IgE-dependent transcriptional program associated with immune regulation www.biorxiv.org/content/10.64898/2026.02...

Una bacteria de la saliva 'protege' de la alergia al cacahuete, destruyendo en la boca las proteínas dañinas Dos personas alérgicas a un mismo alimento pueden tener reacciones de diferente intensidad. Lo que una tolera sin problemas, en otra desencadena una fuerte respuesta. Entre las...

Muy agradecidos a El Mundo por divulgar nuestro trabajo en
@cp-cellhostmicrobe.bsky.social donde demostramos que #bacterias orales degradan #alérgenos alimentarios, modulando respuestas #IgE y #anafilaxia.
www.elmundo.es/ciencia-y-sa...

Alergia al cacahuete: la ciencia mira a la boca para frenar la enfermedad La saliva, clave contra la alergia al cacahuete, según el hospital La Princesa de la Comunidad de Madrid y la Universidad de Canadá

La saliva, clave contra la alergia al cacahuete, según el hospital La Princesa y la Universidad de Canadá: okdiario.com/salud/saliva...

Human oral microbes degrade peanut allergens, thereby reducing IgE recognition, systemic availability, mast cell activation, and anaphylaxis @cp-cellhostmicrobe.bsky.social
www.cell.com/cell-host-mi...

Las bacterias de la saliva pueden ayudar a reducir las reacciones alérgicas al cacahuete Un equipo científico de España y Canadá ha demostrado que ciertos microorganismos presentes en la boca influyen en la respuesta del sistema inmunitario frente a este alimento. Los resultados revelan nuevas vías de prevención centradas en el equilibrio de la microbiota.

Las bacterias de la saliva pueden ayudar a reducir las reacciones alérgicas al cacahuete: www.agenciasinc.es/Noticias/Las...

Your microbiome may determine your risk of a severe allergic reaction The microbes that live in our mouth and gut may influence whether an allergic reaction to peanuts is mild or life-threatening, and could be harnessed to ward off a severe attack

The microbes that live in our mouth and gut may influence whether an allergic reaction to peanuts is mild or life-threatening, and could be harnessed to ward off a severe attack

Our pleasure, Salva! :)

B lymphocytes that enter the germinal center late preferentially differentiate into memory cells that recognize subdominant epitopes @cp-immunity.bsky.social
www.cell.com/immunity/ful... @rockefeller.edu

🧵 1/6 Vaccinating allergic patients carries risks: the patient’s IgE recognizes allergen extracts and can trigger severe adverse reactions. To address this, Dr. Roy Patterson (1970s) proposed an innovative approach: modifying the extracts by polymerizing them with glutaraldehyde.

Today at #PreprintHub2, Elisa Sánchez from Universidad Autónoma de Madrid will present the preprint by @alexaweingarden.bsky.social, “Gut microbial composition modulates food-specific CD4+ T cells in food allergy” from the Marc K. Jenkins lab 🥜🤒❌

www.biorxiv.org/content/10.1...

@biorxivpreprint.bsky.social A single-cell atlas of intestinal immune cells across the day-night cycle reveals dynamic populations
www.biorxiv.org/content/10.6...
@jkpfeiff.bsky.social @utswim.bsky.social @lhooperlab.bsky.social

Review @natrevimmunol.nature.com
How crosstalk at the immune synapse shapes T cell and dendritic cell biologys
www.nature.com/articles/s41...

New tech adventure: co-founded Newton Biotwins together with @mirobueno.bsky.social. We're building #DigitalTwins for the lab — starting with a flow cytometry twin. Turning #biology into an information science! newtonbiotwins.com/en/home_en/

Growth control as a central regulator for tuning the cellular context The cellular context interacts with genetic circuits, decisively defining their performance. However, contextual dependencies (the interplay between the host and the circuit) are often difficult to en...

Preprint out! By controlling growth, via RNAP, we control the entire cellular machinery, and tune the cellular context into distinct, stable states. See how NOT gates behave! Kudos to @angeles-hg.bsky.social and @mirobueno.bsky.social

🔗www.biorxiv.org/content/10.64898/2025.12...

Grateful for the invitation to present at the 3rd Research Day of the METRI²A Group at @idibaps.bsky.social. A pleasure to discuss how #microbial metabolism of allergens impacts #allergicinflammation and #anaphylaxis.

Farm exposure in infancy is associated with elevated systemic IgG4, mucosal IgA responses, and lower incidence of food allergy Infants from a traditional farming community exhibited antibody profiles that were found to be associated with lower incidence of egg allergy.

Researchers in #ScienceTranslationalMedicine find a distinct #Bcell and antibody profile in infants and mothers in an Older Order Mennonite farming community, associated with lower incidence of egg #allergy. https://scim.ag/48rPBGS

We enjoyed discussing in @allergy-eaaci.bsky.social the findings by Cembellin-Prieto et al. (@johnshopkinsmmi.bsky.social) published in @natimmunol.nature.com, who identified a regulatory #mechanism mediated by #Bcell-derived #acetylcholine during #influenza #infection.

doi.org/10.1111/all....

“The bad review will come from your list of suggested reviewers”