Excited to share our new paper: "Genome-wide cfDNA fragmentation patterns in cerebrospinal fluid reflect medulloblastoma groups."
nature.com/articles/s41...
#Medulloblastoma #Fragmentomics #LiquidBiopsy #cfDNA #CerebrospinalFluid
Schematic of the study design. Clinical arm, left: rapid turn-around reporting of sequence and copy number variants (CNVs) from Panel-Seq of relapse tissue from 20 centers across the UK. Research arm, right: comparative studies between diagnostic or relapse tissue samples and cfDNA at relapse. Panel-Seq and lcWGS were performed for all analytes if possible, with Panel-Seq taking priority. lcWGS was utilised for CNA, tumour purity/ ctDNA content estimation and fragmentomics of cfDNA
Now in Cancer Discovery: Stratified Medicine Pediatrics: Cell-Free DNA & Serial Tumor Sequencing Identifies Subtype-Specific Cancer Evolution & Epigenetic States - by Sally George, Claire Lynn, Reda Stankunaite, Andrea Sottoriva, Louis Chesler, et al. doi.org/10.1158/2159... @icrlondon.bsky.social