Learn how we used Droplet Paired-Tag to assess RNA expression and histone modifications in individual brain cells and PBMCs to identify novel cell-type-specific CREs and heritability factors linked to AD
#Epigenetics #SingleCell #DropletPairedTag #PairedTag #Multiomics #Alzheimers
bit.ly/4kgWMF3
Epigenetics Update - Redox rhythms promote fitness by modulating ageing-dependent reprogramming go.nature.com/4cC6IXe
Hou-Zao Chen, Jian-Fei Pei, and De-Pei Liu reporting in Nat Metab
#Epigenetics #Metabolism #Aging #Redox
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Perfect for cancer, immunology, and aging research; epigenometech.com
Epigenetics Update - The discovery of 5mC-selective deaminases and their application to ultra-sensitive direct sequencing of methylated sites at base resolution bit.ly/3ORGNTA
Peter R. Weigele/ ettwiller.bsky.social (nebiolabs.bsky.social) in Mol Cell
#Epigenetics #DNAm
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epigenometech.com
New Epigenome Technologies Blog! bit.ly/4czHSY9
PARM Predicts Promoter Activity from DNA Sequences
A new study reports a “promoter activity regulatory model” as an efficient means of predicting promoter activity from DNA sequences
#Epigenetics #Blog #PARM
Epigenetics Update - FOXF1/2 establish a senescence-specific enhancer landscape to activate the pro-inflammatory senescence-associated secretory phenotype bit.ly/4tlF8oz
Kan Etoh and Mitsuyoshi Nakao from Kumamoto University in Mol Cell
#Epigenetics #Senescence #Enhancers
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epigenometech.com
Epigenetics News - Novel tool could identify new therapeutic targets in complex diseases like cancer
News - bit.ly/4myw9xD Study - go.nature.com/483wgv0
#Epigenetics #News #Chromatin #Cancer
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High-resolution insights without cell sorting; epigenometech.com
Download our poster to learn how we used single-cell CUT&Tag and Droplet Paired-Tag to profile PBMCs, generating over 70,000 single-cell profiles and identifying vast numbers of cis-regulatory elements.
#Epigenetics #SingleCell #DropletPairedTag #PairedTag #Multiomics
bit.ly/4kgWMF3
Epigenetics News - Epigenetic changes at birth are associated with an microbiome and neurodevelopment
News - bit.ly/4svpN3g Study - bit.ly/4t6qFfM
#Epigenetics #News #Microbiome #Neurodevelopment
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Empower your research at epigenometech.com
Epigenetics Update - Spatial and single-cell characterization of human glioblastoma tumor microenvironment reveals malignant cellular communities go.nature.com/4cbyeMo
#Epigenetics #GBM #Multiomics #TME #SingleCell
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Perfect for cancer, immunology, and aging research; epigenometech.com
We offer an end-to-end single-cell Paired-Tag service, the first multiomic assay that simultaneously captures RNA expression and epigenetic marks - our expert scientists run the entire workflow on your samples - from preparation to data analysis
#Epigenetics #SingleCell #PairedTag
bit.ly/3HWFoaw
Epigenetics Update - Histone decrotonylation plays a distinct role in HIV latency bit.ly/3ODZlqn
Xiaoyi Li and Guochun Jiang from the University of North Carolina in Science Advances
#Epigenetics #HistoneCrotonylation #HIV
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Gain deeper insights into gene regulation; epigenometech.com
Epigenetics Update - KDM3A catalyses the oxidation of acetyl-lysine to hydroxyacetyl-lysine on histone H3K9 go.nature.com/4sEZ2cF
@kawamuragroup.bsky.social and Christopher J. Schofield in @natchem.nature.com
#Epigenetics #KDM3A
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Discover the breakthrough at epigenometech.com
New from Epigenome Technologies: Paired-Tag - the first single-cell multiomic assay that simultaneously captures RNA expression and epigenetic marks
#Epigenetics #SingleCell #PairedTag #Multiomics
Find out more at: bit.ly/4efqM1Y
Epigenetics Update - Linker histone H1 functions as a liquid-like glue to organize chromatin in living human cells bit.ly/4el3JVy
@masaashimazoe.bsky.social and @rcollepardo.bsky.social / @kazu-maeshima.bsky.social in Science Advances
#Epigenetics #Chromatin #HistoneH1
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epigenometech.com
Epigenetics Update - H2AK119ub1-MLL2 counteraction underlies heritable H3K27me3 formation in oocytes bit.ly/4ctnKqx
Hailiang Mei and Azusa Inoue from RIKEN in Mol Cell
#Epigenetics #H3K27me3 #Oocytes #Chromatin
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Empower your research with high-res epigenetic insights at epigenometech.com
Check out the San Diego MultiomicsMixer at Mission Brewing – East Village if you'll be at AACR in San Diego next week!
Epigenome Technologies offers an end-to-end Single-Cell CUT&Tag service
Our expert scientists run the entire workflow on your samples - from preparation to data analysis
#Epigenetics #SingleCell #CUTandTag
Find out more at: bit.ly/4kPxe2i
Epigenetics Update - Postmitotic transcription and 3D regulation show locus-specific and differentiation-specific sensitivity to cohesin depletion go.nature.com/48ISkLD
UkJin Lee and @efapostolou29.bsky.social at @weillcornell.bsky.social
#Epigenetics #Chromatin
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epigenometech.com
Epigenetics Update - De novo formation of cis-regulatory contacts in the absence of NIPBL-driven chromatin loop extrusion go.nature.com/4cnKLeo
@nicholas-aboreden.bsky.social/Han Zhao and Haoyue Zhang/Gerd A. Blobel in @natgenet.nature.com
#Epigenetics #Chromatin
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epigenometech.com
New from Epigenome Technologies: the first fully validated Single-Cell CUT&Tag kit
Fully compatible with 10x Chromium® (ATAC), Fluent PiP-seq®, or BD Rhapsody
#Epigenetics #SingleCell #CUTandTag
Find out more at: bit.ly/4lquJDv
Epigenetics Update - Linker histone H1 represses H3 tail acetylation induced by H4 tail acetylation and alters its dynamics go.nature.com/3Q6YP4D
Ayako Furukawa and Yoshifumi Nishimura in Commun Biol
#Epigenetics #Acetylation #Chromatin
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Discover the breakthrough at epigenometech.com
Epigenetics Update - Integration of aged brain multi-omics reveals cross-system mechanisms underlying Alzheimer’s disease heterogeneity bit.ly/4ciTPkO
Lucas P Scheidemantel and Ricardo A Vialle in Cell Rep
#Epigenetics #Multiomics #Alzheimers
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epigenometech.com
We are now on Substack!
Come find us at epigenometech.substack.com for our long-form pieces!
#EpigenomeTech #Blogs #Substack #PairedTag #SingleCell #Multiomics #Chromatin
Epigenetics News - Researchers find new target to sensitize pancreatic tumors to immunotherapy
News – bit.ly/4tHGBoX Study - bit.ly/41oVznK
#Epigenetics #Cancer #Immunotherapy
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Gain deeper insights into gene regulation; epigenometech.com
Epigenetics Update - Histone acetylation-dependent clustering of BRD2 instructs transcription dynamics go.nature.com/4tJjSJ7
Niyazi Umut Erdogdu and asifa-akhtar.bsky.social at @mpi-ie.bsky.social in Nat Genet
#Epigenetics #Chromatin #BRD2
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Discover the breakthrough at epigenometech.com
New Epigenome Technologies Blog! bit.ly/420ajta
Do Cellular Metabolism and the Nuclear Lamina Function Shape Cell Fate Through Epigenetic Mechanisms?
Based on a Nature Metabolism Paper from Yinuo Wang, Sofia-Iris Bibli, and Gergana Dobreva
#Epigenetics #Metabolism #Blog
Epigenetics Update - Single-cell spatiotemporal dissection of the human maternal–fetal interface go.nature.com/4vk494K
Susan J. Fisher and Jingjing Li (UCSF) in Nature
#Epigenetics #SingleCell #MaternalFetalInterface
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High-resolution insights without cell sorting; epigenometech.com
Epigenetics Update - PHIP suppresses NuRD to enable the growth of SWI/SNF-mutant cancers go.nature.com/48iTyx2
Hayden A. Malone and Charles W. M. Roberts in Nat Commun
#Epigenetics #Chromatin #Cancer
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Empower your research with high-res epigenetic insights at epigenometech.com
Learn more about single-cell epigenetic profiling by downloading our guide to single-cell CUT&Tag and single-cell Paired-Tag, which provides comparisons to other methods and bioinformatic insight
bit.ly/4r7CGRD
#Epigenetics #Multiomics #CUTandTag #10XGgenomics #ChIPSeq #SingleCell #PairedTag
Epigenetics News - Blood-based DNA signals may help track osteosarcoma in children
News bit.ly/4t0CXGK Study go.nature.com/48hFdAW
#Epigenetics #DNAm #Osteosarcoma
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Empower your research with high-res epigenetic insights at epigenometech.com