What if you got to work with some of your best friends on a science project? I can't publish how fun this was, but I can show you the data (🧵)! Last week, we posted our second neutrophil swarming paper to bioRxiv and I wanted to post my favorite videos here~
www.biorxiv.org/content/10.6...
UFMylation, discovered for the first time in mitochondrial proteins, is found to keep pyruvate dehydrogenase activity and downstream glucose oxidation in check.
Hannah Pletcher (@nieminm.bsky.social lab) highlights work from @rjdlab.bsky.social
#preLight ⬇️
prelights.biologists.com/highlights/u...
New Pre-Print Alert!
Evolving initial conditions: an alternative developmental route to morphological diversity
with Shannon Taylor and @jamesehammond.bsky.social
www.biorxiv.org/content/10.6...
Aware of the idea, blind to the details.👀
Maitri highlights work that asks whether people can become aware of what something is without seeing how it looked. #preprint from the group of @clairesergent.bsky.social #Consciousness
Check out the #preLight ⬇️
prelights.biologists.com/highlights/c...
How do funding decisions shape the direction of biomedical research? Can we spot transformative discoveries years before they are recognised by prizes, policies, or the wider community?
Watch the #spotLights discussion feat. @kawillis.bsky.social & @jontytownson.bsky.social
youtu.be/u-X3dYl7dHQ?...
From molecules to morphogenesis
Discover a curated #preList of preprints presented at the BSDB Spring Meeting @bsdb.bsky.social - highlighting exciting new research in developmental biology
Explore this #preprints list prepared by @ingridtsang.bsky.social ⬇️
prelights.biologists.com/prelists/bsd...
Mapping nerves in a whole embryos.
We find that across species and development stages, embryonic nerves display (beautiful) fractal geometry.
More here: www.biorxiv.org/content/10.6...
Evolutionary landscape of endomembrane systems. On top are two possible endomembrane systems, represented as directed graphs (pER: proto-endoplasmic reticulum; PM: plasma membrane; IC: intracellular compartment). In the layer below, endomembrane graphs are represented as nodes (white dots) connected by evolutionarily viable transitions (red lines). Collectively these dots and lines define an evolutionary landscape. The landscape breaks up into less functional (left) and more functional (right) endomembrane systems, introducing a selective bias.
How did eukaryotic cells get their Golgi, endosomes, lysosomes and other endomembrane compartments? We show that endomembrane evolution depends on long periods of neutral molecular exploration, punctuated by sudden leaps.
New preprint: www.biorxiv.org/content/10.6...
🚨 New lab preprint alert! 🚨
A study 6 years in the making, made possible by @simonsfoundation.org support : "A multi-omic atlas in the African turquoise killifish reveals increased glucocorticoid signaling as a hallmark of brain aging" now on #biorXiv: www.biorxiv.org/content/10.6... A 🧵 1/11 🧪🖥️🧬
How can we learn tissue mechanics directly from cell patterns and images?
In our new preprint, we introduce VertAX, a differentiable vertex-model framework in JAX for simulating epithelia, inferring parameters, and designing target tissue behaviors.
shorturl.at/PUzT0
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Congrats to the newest PhD from the @siegenthalerlab.bsky.social, Dr. Sophia Kim! Beautiful thesis document & presentation! 🧠🦠🔬🎉
Sophia's thesis work on arachnoid barrier breakdown in meningitis is on bioRxiv - check it out!
www.biorxiv.org/content/10.6...
I am excited to share our most recent work collaborating with @centriolelab.bsky.social and @stearnslab.bsky.social to look at the ciliary base of mammalian multiciliated cells w/ cryo-ET, XL/MS, and U-ExM www.biorxiv.org/content/10.6...
2️⃣ DcpS undergoes amyloid aggregation and liquid–liquid phase separation under specific conditions. Disease-associated mutants show enhanced aggregation, supporting a role in initiating or worsening #proteinopathies. #preprint
#preLight by Joao Gabriel ⬇️👀
prelights.biologists.com/highlights/l...
Another two preLights resulting from the preprint review initiative led by Marcus Oliveira #UFRJ
1️⃣Exploring and characterising the peptide QBP1 as a promising inhibitor of amyloid aggregation in proteins linked to type 2 diabetes
#preLight by Joao Gabriel ⬇️
prelights.biologists.com/highlights/a...
Shining light on a dark metabolite: 4,5-DHHA as a potential #biomarker for mitochondrial disease with respiratory chain dysfunction. 🔦
New post by Hannah Pletcher on work from Owen S. Skinner & colleagues #mitochondria #biochemistry
#preLight ⬇️👀
prelights.biologists.com/highlights/4...
Mirror mirror on the wall who is the brightest of them all?
Brightness is a key parameter for choosing fluorescent reporters in bioimaging. As tricky to assess, we present a pipeline to compare chemigenetic labels and FPs in tissue culture and #zebrafish embryos.
www.biorxiv.org/content/10.6...
PREPRINT ALERT !!!
Excited to share our #reptile #embryo cryopreservation method optimised on peri-gastrulation veiled chameleon embryos! This lays the foundation for functional studies & reptile #conservation efforts!
#devbio #squamates #evodevo
www.biorxiv.org/content/bior...
Attachment of ADP-ribose molecules to RNA Polymerase II allows its traffic regulation on transcribed genes in response to oxidative DNA damage 🧬
Insightful #preLight by Élise & @pierrecaron.bsky.social on preprinted work from @gregersenlab.bsky.social⬇️👀
prelights.biologists.com/highlights/o...
Excited to share our new #preprint uncovering how early human forebrain is patterned.
Compared to mouse, human dorsoventral and anteroposterior telencephalon patterning is strikingly delayed, which is correlated with SHH and FGF signalling differences.
Read it here: www.biorxiv.org/content/10.6...
New preprint from the lab!
How do tissue shapes influence cell fate decisions?
By manipulating brain organoid geometry, we show that lumen rounding directs apical progenitor division mode and promotes the emergence of basal progenitors.
www.biorxiv.org/content/10.6...
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New preprint! We sequenced 175 'Alalā (Hawaiian crow) genomes to understand why >50% of eggs fail to hatch in a species recovered from just 9 individuals. What we found was a both exciting and surprising. www.biorxiv.org/content/10.6...
We might be close to obliterating poliovirus, but non-polio enteroviruses are on the horizon.
@sergiuppasca.bsky.social & team use a human assembloid model to show how poliovirus, EV A71 & EV D68 disrupt neuromuscular function in different ways.
#preLight ⬇️
prelights.biologists.com/highlights/h...
Delighted to share our preprint describing COMET, a new approach to drift correction for #SMLM, which performs exceptionally well in practice. Check out the benchmarking results compared to other methods! :) Thanks to @lreinkensmeier.bsky.social for a superb effort.
www.biorxiv.org/cgi/content/...
Meiosis faces a fundamental problem:
It must repair hundreds of DNA double-strand breaks while executing a transcriptional programme essential for gamete development.
But many of these breaks occur in genes.
So how are these two processes reconciled?
www.biorxiv.org/content/10.6...
New #preprint 😍‼️ led by 2 incredible postdocs @ninizhani.bsky.social & Ranj Papareddy: transforming #UFMylation from a local ribosome rescue pathway to systems level regulator of mRNA splicing www.biorxiv.org/content/10.6... A short 🧵
❓A one-time, durable, and even reversible way to prevent thrombosis? In this preprint, led by @lrbzldz.bsky.social, we show that epigenome editing of 🩸 #StemCells can durably reprogram platelet function: www.biorxiv.org/content/10.6...
Check out our new preprint and learn about the smart foraging behavior of fly larvae!
www.biorxiv.org/content/10.6...
Check out our first lab preprint: A real team effort to understand the Plasmodium GAPM proteins, which form part of a essential bridge between the parasite's cytoskeleton and motility apparatus. Below is a sneak peek of some beautiful microscopy - light and electron! www.biorxiv.org/content/10.6...
Structure of SARS-CoV-2 spike in complex with its co-receptor the neuronal cell adhesion protein contactin1
www.biorxiv.org/content/10.6...
Check out our new preprint. Cool structure by Sabrina Krepel with Bert Janssen.
Thanks to @danielhurdiss.bsky.social @utrechtvirology.bsky.social #covid #pais
Posting on behalf of (soon-to-be) Dr. Samira Monshietehadi (not on Bluesky) -- "I’m very excited to announce that my PhD thesis project is now a preprint! www.biorxiv.org/content/10.6.... We show how Müller glia engage with growing retina vasculature in an activity-independent manner."(1/11)
