www.nature.com/articles/s41...
Excited to have this collaboration from #QVEU and @rongellerlab.bsky.social lab out in the world! After publishing our own #DeepMutationalScanning studies on two related viruses, we asked what we learn from comparisons of such datasets. The answer is a lot!
Which paper is it!
Postdoc Position in Virology (1yr, renewable) We are launching M+RVL, a new research group dedicated to better understanding the fundamental mechanisms of positive-strand RNA virus replication. Supported by the LabEx NetRNA research cluster, the team is based within the Mosquito Models of Innate Immunity (M3I) unit at the Institute of Molecular and Cellular Biology (IBMC) in Strasbourg, France. Strasbourg is a lively city in northeastern France that offers a high quality of life, a vibrant university system, and a historic city center at the heart of Europe. Research Focus Replication organelles (ROs) are membrane-bound compartments that drive genome replication in positive-strand RNA viruses. Mosquito-borne viruses must assemble ROs in both mosquito and vertebrate hosts, which are separated by hundreds of millions of years of evolution. While structural biology has revealed the architecture of ROs in human cells, structure alone cannot explain their assembly, dynamics, and host-specific interactions, highlighting the need for integrative approaches. To address this gap, M+RVL integrates high-throughput genetics, proteomics, and computational modeling to dissect the mechanisms governing RO formation and function across hosts. Research Leadership The group is led by William Bakhache, Ph.D. Essential Skills: Strong background in virology, molecular biology, and biochemistry techniques. Desired Experience: Experience handling BSL-3 pathogens; expertise in computational biology (e.g., NGS analysis, proteomics data analysis, structural modeling). How to Apply Please send a single PDF containing a cover letter (detailing past and future research interests), a CV, and contact information for two references to williambakhache@hotmail.com.
Post-doc job alert! Please share with anyone who might be interested! @amersocvirology.bsky.social #virology #virosky #evolution
Hi all,
I'm currently hiring a postdoc to join me in opening a new research team in Strasbourg, France, funded by the LabEx NetRNA research cluster!
I would appreciate it if you could share this opportunity on LinkedIn and in your relevant research networks.
Thank you.
Great post, thank you for sharing!
What the..wow!
My first #QVEU postdoc, William @williambakhache.bsky.social is off to start his group at labex-netrna.cnrs.fr/presentation... in Strasbourg, FR. We’ll miss his leadership and friendship, but I’m so excited to see what he’s got planned. If you want to book a ticket on this rocketship, reach out! 🦠🧪
New #QVEU preprint! @williambakhache.bsky.social used our #EV71 mutational scanning library to dissect replication complex function with a collection of inhibitors against specific host and viral factors. Then used the data to validate structural predictions! Super cool #virosky #virus #evolution
Congrats! Very cool work.
Am not sure. It still cannot handle all amino acids yet too. But, still, it looks promising!
Maybe soon with protein sequencing?... 😶🌫️ Like the Quantum Si tech
Depends how cold...it's -6 degrees here in DC 😶🌫️
Very nice! Congrats on the ANKLE2 paper, beautiful work.
Cool :O what is happening between the DNA and the stress fibers haha.
These stress fibers are beautiful.
Excited to have this second paper out from the QVEU! Postdoc @williambakhache.bsky.social led this effort along with @orrwalk.bsky.social and Lauren McCormick to explore the tolerance of the Enterovirus EV-A71 to substitutions, insertions, and deletions. www.nature.com/articles/s41...