SPNS1 is an essential cellular factor for EV-A71 by acting as a transporter of viral pocket factor.
Fu, Yu-Zhi et al.
Paper
Details
#EV71 #SPNS1 #pocketfactor

Genotype-by-Inhibitor Interactions to Dissect Enterovirus Replication Replication organelles of positive-sense RNA viruses are essential to virus biology, yet their molecular mechanisms remain poorly defined. While deep mutational scanning (DMS) measures the impact of m...

New #QVEU preprint! @williambakhache.bsky.social used our #EV71 mutational scanning library to dissect replication complex function with a collection of inhibitors against specific host and viral factors. Then used the data to validate structural predictions! Super cool #virosky #virus #evolution

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Blocking CCL3-mediated neutrophil recruitment into the brain alleviates immunopathology following severe #enterovirus 71 infection

www.cell.com/iscience/ful... #MicroSky #OpenAccess #EV71