Another postdoc position for my lab is now open. This one is for a biochemist/cell biologist who really likes mitochondria and ubiquitin. If this is you, please apply here: www.seek.com.au/job/91277535
The cartwheel was first visualized ~70 years ago in the symbiont Trichonympha in the wood termite gut. We’ve discovered the cartwheel’s secret: a unique zigzag stacking of SAS-6 tetramers that facilitates the iconic 9-fold symmetry of cilia.
#cellbiology #teamtomo #SAS6 #cartwheel
One of biggest mysteries in biology: how did complex eukaryotic cells evolve from simple microbes? ~1.8 billion years ago, an archaeal cell likely merged with a bacterium to form the first eukaryotic cell, but can we ever find direct evidence of this transformative event? 🦠 🚶♂️
Coool!! I didn’t know this!
Not completely related, but somehow resonates with the idea that plants are not the helpless organisms we always thought about: www.science.org/doi/10.1126/...
Molecular architecture of the ciliary base in mammalian multiciliated cells www.biorxiv.org/content/10.64898/2026.04...
Blender Rendering of vitrified HA trimer with DM at the air-water interface
We identified the maltoside detergent DM as an effective and easy solution to address preferred orientation in cryo-EM. Helped me switch from graphene grids. Special congrats to Maria Rafiq! @landerlab.bsky.social @nanigrotjahn.bsky.social @wisemanlab.bsky.social #cryoEM doi.org/10.64898/202...
Amazing! Congratulations!
More on Pablo et al's study with nice tide pool octopus photos from Anik Grearson :)
wapo.st/47D71zu
Proud to share the yeast telomerase structure, led by the talented @hongmiaohu.bsky.social in collaboration with the Wellinger and Chartrand labs. Discovered 37 years ago and took us nearly 7 years but totally worth the wait 😍.
www.science.org/doi/10.1126/...
www.youtube.com/watch?v=gFE4...
Excited to share our work on the structure and function of cytoplasmic lattices within mouse embryos. A collaborative effort with @niakanlab.bsky.social and work led by @kashishsingh.bsky.social and @inaharasimov.bsky.social . It is now out on BioRxiv: www.biorxiv.org/content/10.6...
We're excited to announce the beta-release of #RELION-5.1! 🥳 This release has important updates on our #amyloid processing pipeline, as described in this preprint: doi.org/10.64898/202... There are also some tweaks for #teamtomo.
#OpenSoftwareAcceleratesScience
If you can, I would suggest you to search for “pasta dei cornuti” (literally, “pasta of the cheated husbands”). You would get some important and interesting insights about the recipe’s tradition -in Italy, at least
From what I remember (very little) was from wheat germ lysate, but yes, it was not in cells
Wow! From C39 to C13! Congratulations @olibclarke.bsky.social @fravallese.bsky.social
The vault particle is enclosed by a C13-symmetric cap with a positively charged exterior pubmed.ncbi.nlm.nih.gov/41706843/ #cryoEM
Oh, I remember that one, it was nice! Or a paper from Spirin, a NAR from 2016 I guess?
Pulsed #lasers integrated with #cryoEM: @fitzpatricklab.bsky.social postdoc Daniel Du aims to boost contrast in #cryoET zuckermaninstitute.columbia.edu/making-world-s-best-microscopes-biology-better
zuckermaninstitute.columbia.edu/science-life-daniel-du
elifesciences.org/reviewed-preprints/109793v1
Integrase anchors viral RNA to the HIV-1 capsid interior pubmed.ncbi.nlm.nih.gov/41708858/ #cryoEM
Helical polysome, maybe?
Max Fels @mfels.bsky.social from our lab discovers giant DNA viruses that infect amoeba encode eIF4E and the entire suite of 4F complex proteins to control mRNA translation, including beautiful crystal structures of viral 4E bound to modified mRNA 5' caps:
www.cell.com/cell/fulltex...
Beautiful #phage structure 🤩
Congrats to the colleagues in Brazil! 🍊🦠
www.biorxiv.org/content/10.6...
#CryoEM #xanthomonas
I had Claude make this as a mini-game for Relay's disconnect screen (like Chrome's dinosaur), but then pivoted to stand-alone. In this game, you have to find Euler angles matching the target projection, i.e. cosplay RELION. It can be pretty hard. Works on mobile too! warpem.github.io/euler-hunt/
I admit I’m completely ignorant about replication, I just have some structural-based ideas on the reason ssDNA is not working as mRNA during translation, but geometry is a likely explanation
That 2’-OH is amazing. Maybe 2’-5’ would not have the same torsional freedom as 3’-5’?
How could a simple self-replicating system emerge at the origins of life? RNA polymerase ribozymes can replicate RNA, but existing ones are so large that their self-replication seems impossible. Could they be smaller?
Excited to share our latest work in @science.org on a new small polymerase.
1/n
It took a while but it’s finally published!
The GAP activity of SEAC (GATOR) is a metabolic switch that allows cells to quickly respond to changes in amino acid levels, both for inhibition and reactivation.
Great Jan, congratulations!!
What organism? Mario Halic apparently improved Chlamy’s nucleosome to 4.2 (EMPIAR 11-830) (unofficial, I think)
Figure 1c is amazing.
Great work, congratulations
