Management of patients with antiphospholipid antibodies or antiphospholipid syndrome during pregnancy - PubMed Obstetric APS remains a major cause of maternal-fetal morbidity. Advances in understanding placental inflammation have expanded potential therapeutic targets, but standardized treatment remains limite...

New review on #APS in #pregnancy looks beyond clotting alone, highlighting the possible role of #inflammation in pregnancy complications. It also explores pre-conception care, pregnancy management and future treatment approaches. Read more: pubmed.ncbi.nlm.nih.gov/41830410/

An Experience from Hell: Pulmonary Embolism, DVTs and Antiphospholipid Syndrome

"All I could do for the first few weeks was to focus on fighting the #pain, 24 hours a day. Distractions such as conversations or books only exhausted me further.": buff.ly/uvgdHdQ

#ChronicPain #spoonie #AntiphospholipidSyndrome #MondayBlogs #ChronicIllness #DVTs #PulmonaryEmbolism #MedSky

‘I don’t feel good’: Person goes to urgent care after finding ‘suspicious lines’ under her nails. Doctors immediately send them to the hospital An internet user says the discovery of lines under their finger nail caused them to have a hospital visit. What do these lines mean?

Seen the viral “lines under the nails” story? www.themarysue.com/lines-under-...

These can be splinter haemorrhages—rare in APS and not usually the first sign. They can also have other causes (including nail trauma). Learn more here: aps-support.org.uk/about-aps/wh...

New Nature study: age-acquired somatic mutations in immune B cells may help trigger autoimmune disease (shown in thyroid autoimmunity), with potential relevance across autoimmunity. Read: www.cuh.nhs.uk/news/secret-...

🥇 Go for gold with TUI 🥇

Book your 2026 holiday with TUI:

🎉 1 in 10 bookings wins a £500 bonus donation
💸 Raise a £50 donation for your cause just by booking

Don’t miss out - book with TUI through easyfundraising by 3rd May to be in with a chance to win for your cause. ☀️🌊

New ISTH Pulse Podcast episode! The countdown to the #ISTH2026 Congress is on and this episode takes you behind the scenes of the Congress program🎧: soundcloud.com/isth_thepuls... #ISTH2026

💡 BONUS: Don't miss the April edition of the Congress Chronicle by Walter Ageno: www.isth.org/news/news.as...

APS Support UK graphic promoting the National Thrombosis Week Conference (5–8 May 2026) by Thrombosis UK. Central circular logo on a white panel with the text ‘Secure your free place, tickets available now!’ Pink/red border with blood cell imagery in the background, and the APS Support UK logo in the bottom-left corner.

National Thrombosis Week Online VTE Conference (5–8 May 2026) — FREE + 15 CPD credits. APS Support UK will have an online booth (more details soon). Register: tuk-edu.vfairs.com

#VTE #Thrombosis #CPD #Haematology #APSSupportUK @thrombosisuk.bsky.social

Relevance of isolated IgM antiphospholipid antibodies in a longitudinal cohort of antiphospholipid syndrome AbstractObjectives. IgM anticardiolipin (aCL) and anti-β2 Glycoprotein I (aβ2GPI) positivity have been downgraded in the current classification criteria fo

Relevance of isolated IgM antiphospholipid antibodies in a longitudinal cohort of antiphospholipid syndrome academic.oup.com/rheumatology... #hvhebron #medint

Woman with rare clotting syndrome denied life-saving heart surgery in UK

Medical Denial Compounds Rare Condition Struggles

Megan Hetherington, 27, denied heart valve surgery due to antiphospholipid syndrome. Doctors advise living each day as her last.

#RareDisease, #HeartSurgery, #Antiphosphol...

newsletter.tf/woman-denied-heart-surge...

NEWS: @ash.hematology.org and the ISTH published a new clinical practice guideline on anticoagulant prophylaxis in pediatric patients at risk of VTE!

The recommendations outline best practices for preventing life-threatening complication in children. Learn more: www.isth.org/news/news.asp?id=724974

How Does Antiphospholipid Syndrome Affect The Body? (Beyond the Blood to Major Organs)

"A #stroke ..is one of the big bad ones when #AntiphospholipidSyndrome misbehaves..more than 20% of #strokes in patients younger than 45 years of age may be attributed to APS..also more common in males.": buff.ly/rSk1XA3

#neurology #ChronicPain #awareness #BloodClots #ChronicIllness #MedSky

Woman with three deadly diseases has ‘remarkable’ recovery after cell therapy Treatment reset wayward immune system of patient with life-threatening conditions, say scientists, in a world first

CAR-T therapy for autoimmune haemolytic anaemia (AIHA) / immune thrombocytopenia (ITP) / antiphospholipid syndrome (APS):

CD19 CAR-T therapy induces remission in refractory autoimmune hemolytic anemia with ITP and antiphospholipid syndrome @cp-med.bsky.social
www.cell.com/med/abstract...

CD19 CAR-T therapy induces remission in refractory autoimmune hemolytic anemia with ITP and antiphospholipid syndrome This single-patient case report expands the indications in which CD19 CAR-T cell therapy demonstrates unprecedented clinical efficacy, achieving sustained, treatment-free remission. Following B cell abrogation, AIHA is stopped, antiphospholipid antibodies are abrogated, and an underlying ITP is stabilized without any CAR-typical side effects.

Online Now: CD19 CAR-T therapy induces remission in refractory autoimmune hemolytic anemia with ITP and antiphospholipid syndrome

Diagnostic, research, and real-life effect of the 2023 EULAR−ACR classification criteria for antiphospholipid syndrome The role of classification criteria is particularly important in rheumatic diseases compared with other medical disorders, as the complexity and overl…

New Personal View in The Lancet Rheumatology: APS classification criteria are for research — not the same as diagnosis in routine care. Focuses on pregnancy-related APS and why this distinction supports optimal care: www.sciencedirect.com/science/arti...

Four-dimensional flow magnetic resonance imaging assessment in a patient with antiphospholipid syndrome and sinus of Valsalva thrombus: a case report AbstractBackground. A thrombus in the sinus of Valsalva (SOV) with a native aortic valve is a rare aetiology of type 2 myocardial infarction. To the best o

New case report: 4D-flow MRI mapped blood flow after a rare sinus of Valsalva thrombus in a patient later diagnosed with APS, suggesting local low-velocity flow/stasis may contribute (“second hit”). doi.org/10.1093/ehjc...

#Antiphospholipid antibodies and #cardiovascular #thrombosis, now in @NatRevCardiol :
dlvr.it/TRQCr6

Systematic summary across various conditions. In some cases, they challenge the old conventional thinking.

This is a paper the #APSFA helped fund.

It's Stress Awareness Month.

Lets talk about #Antiphospholipid Syndrome (#APS), chronic illness, dealing with doctors and insurance this month & the stress of it all and how to deal with it. How do you deal with the stress?

Let's talk about #chronicillness #medicalstruggles #insurancenightmares

Reasons for exclusion from classification based on 2023 ACR/EULAR classification criteria

Evaluating sensitivity of the 2023 ACR/EULAR classification criteria for antiphospholipid syndrome in women diagnosed with primary obstetric APS showed low sensitivity and failed to identify future pregnancy complications

Arthritis Care & Research
doi.org/10.1002/acr....

Frontiers | Genetic determinants of arterial thrombosis in primary antiphospholipid syndrome: a systematic review BackgroundPrimary Antiphospholipid Syndrome (PAPS) is a systemic autoimmune disorder characterized by arterial and/or venous thrombosis and obstetric morbidi...

New systematic review asks: do genetics influence arterial clots in primary #APS? Signals appeared more often in platelet/blood-vessel pathways; classic #thrombophilia variants weren’t consistent. Low-certainty evidence—more research needed. doi.org/10.3389/fimm...

LBA:01:05 Clinical practice in obstetric antiphospholipid syndrome: results from the international OAPS-CARE survey Objectives Obstetric antiphospholipid syndrome (OAPS) remains a significant cause of pregnancy morbidity and continues to present diagnostic and therapeutic challenges. This study aims to evaluate cur...

LBA:01:05 Clinical practice in obstetric antiphospholipid syndrome: results from the international OAPS-CARE survey lupus.bmj.com/content/13/S... #hvhebron #medint [Text complet]

Persistent Antiphospholipid Antibodies, Mast Cell Activation Syndrome, Postural Orthostatic Tachycardia Syndrome and Post-COVID Syndrome: 1 Year On This is the first case report of a patient with post-COVID-19 postural orthostatic tachycardia syndrome (POTS) with multiple persistent antiphospholipid antibody (aPL)-positivity more than a year after illness onset who also meets Global Consensus-2 ...

“Persistent Antiphospholipid Antibodies, Mast Cell Activation Syndrome, Postural Orthostatic Tachycardia Syndrome and Post-COVID Syndrome: 1 Year On” March 2021 pmc.ncbi.nlm.nih.gov/articles/PMC...

A case report of a Long Covid patient with POTS, MCAS & (aPL)-positivity 1 year+ after illness onset

Anti–β2-Glycoprotein I Antibody Titers

Cardiolipin Antibody Titers

A CD19-targeted therapy induced remission in a woman with refractory immune thrombocytopenia and antiphospholipid syndrome by stabilizing platelet counts, eliminating pathogenic antibodies, and enabling safer long-term anticoagulation. Read the full report: nej.md/4cXXAhs

#MedSky

Delighted to welcome Dr. Shruti Chaturvedi to #Stanford Hematology to speak on her important work on thrombotic microangiopathies, complement activation &
antiphospholipid syndrome, looking forward to it! @stanforddeptmed.bsky.social

Pregnacy Complications In Antiphospholipid Syndrome And Other Must Knows. Women's Health and APS. a chronic voice .com

"[The phenomenological study] illustrates the social burdens felt by #patients, with some marriages ending in #divorce due to expectations from husbands & mother-in-laws. The #psychological #suffering of the patient is huge.": buff.ly/lfGI5wF

#WomensHealth #marriage #AntiphospholipidSyndrome

Low platelets (#thrombocytopenia) in APS may signal higher clot risk. A cohort of 211 people with #antiphospholipid antibodies found low platelets in 20% and linked to more clots/recurrence: www.thrombosisresearch.com/article/S0049-3848(25)00294-4/fulltext #APS #Research

Thrombocytopenia in antiphospholipid syndrome: predictors, prognostic implications, and thrombotic risk in a large cohort study - PubMed Thrombocytopenia in APS patients, particularly in severe cases, correlates with heightened thrombotic risk and systemic manifestations. These findings highlight the importance of customized strategies that balance thrombosis prevention with bleeding risk, especially in complex cases.

Early studies suggest certain non-coding RNAs (like lncRNAs XIST & MEG3) may be linked with #APS and could become future biomarkers. Reminder: this is early-stage research: pubmed.ncbi.nlm.nih.gov/41297380/ #AntiphospholipidSyndrome

Frontiers | Maternal and neonatal outcomes in obstetric antiphospholipid syndrome: a retrospective case-control study ObjectiveThe combination of low-dose aspirin (LDA) and low-molecular-weight heparin (LMWH) is the standard of care for obstetric antiphospholipid syndrome (O...

New study in treated obstetric APS pregnancies: standard aspirin + LMWH supports live births, but some risks (anaemia, lower birth weight, newborn jaundice/infection) may need extra monitoring: pubmed.ncbi.nlm.nih.gov/41451085/
#APS #Pregnancy #ObstetricAPS #APSResearch #AntiphospholipidSyndrome

Did You Know? Graphic with pink background and an umbrella icon. Text says: ‘People sometimes say “sticky blood”…but that phrase doesn’t mean one condition. It’s an umbrella label people use for many different clotting disorders.’ APS Support UK logo in the bottom left.

Pink slide with a large question mark. Text reads: ‘What does that mean? “Sticky blood” isn’t a medical diagnosis. It can be used to describe different reasons someone may be more likely to clot… and the cause matters.’ APS Support UK logo in the bottom left.

Pink slide listing conditions sometimes referred to as ‘sticky blood’: antiphospholipid syndrome; inherited thrombophilias (e.g., Factor V Leiden / prothrombin gene variant); Protein C, Protein S and antithrombin deficiencies; myeloproliferative disorders (e.g., essential thrombocythaemia, polycythaemia vera). Includes small medical icons and ‘Swipe for more’ at the bottom.

Pink slide with an illustration of a clinician taking a person’s blood sample. Text says: ‘If you’re navigating testing, appointments, or uncertainty, you’re not alone. Trusted info + support: aps-support.org.uk. Save this post + share it with someone who might need it.’ APS Support UK logo bottom right.

Friendly reminder: ‘sticky blood’ is a vague label, not one condition. It can refer to #APS, inherited #thrombophilias (e.g., Factor V Leiden), or some blood disorders. If you’re unsure, ask your GP/specialist what it means for you: cutt.ly/5tUGjj9x #StickyBlood #AntiphospholipidSyndrome

‘Women just get it more’: autoimmunity and the gender bias in research Asha Torczon explores why the female population are more susceptible to autoimmune diseases and the impact of misogyny in medical research

Autoimmunity often affects women more than men—yet research can be biased. This piece explores why. For #APS, most diagnoses are 20–50 and it’s more common in women (7 women for every 2 men): www.varsity.co.uk/science/30856 #AutoimmuneAwareness #WomensHealth