CD20 tails interact with the 14-3-3/GEF-H1 complex and microtubule network upon PKCδ phosphorylation - The EMBO Journal CD20 is a four-helix transmembrane protein specifically expressed in B-cells that serves as a prominent target of therapeutic anti-CD20 antibodies. It is localized in a membrane nanocluster harboring ...

CD20 tails interact with the 14-3-3/GEF-H1 complex and microtubule network upon PKCδ phosphorylation
Kathrin Kläsener, Michael Reth and collaborators
link.springer.com/article/10.1...

We are looking for an experienced light microscopy specialist, motivated to support our users in the Advanced Light Microscopy Facility at EMBL Heidelberg.
embl.wd103.myworkdayjobs.com/en-US/EMBL/j... -closing date 11 May 2026 @eurobioimaging.bsky.social @globalbioimaging.bsky.social

Interested in #Mechanobiology? Join us for the Mechanobiology Symposium, hosted by the new Cornell Mechanobiology Hub @weillinstitute.bsky.social in Ithaca, NY, this summer. More information at mechanobiology.wicmb.cornell.edu/events-progr...
Deadline for abstract submission is April 15, 2026

A high-affinity split-HaloTag for live-cell protein labeling Nature Communications - Lin and colleagues present high-affinity split-HaloTag pairs for protein tagging and multiplexed labelling. This versatile system allows protein visualisation with diverse...

A high-affinity split-HaloTag for live-cell protein labeling. And much more.
www.nature.com/articles/s41...

Paper Party

@mukherja.bsky.social work on RNAPII clusters is in print today: www.nature.com/articles/s41...
Congrats!
TLDR: RNAPII clusters represent transcriptonally engaged molecules at single genes, not super-stochiometric assemblies.
Please check it out and see the the thread below for a summary.

and check out the animation in the supplement that Hong did (download only) !

Regulation of YAP activity by nuclear G-actin binding Abstract. The Yes-associated protein YAP belongs to the TEAD (TEA/ATTS domain) transcriptional co-activators that shuttle between the cytoplasm and the nuc

Hong's @bdyxwh.bsky.social paper is out with help from @sshamphavi.bsky.social and @archaellum.bsky.social. We discovered a link between nuclear actin and YAP/TAZ: G-actin forms a complex with YAP-TEAD for transcription.
academic.oup.com/nar/article/...

You asked, we listened. Millions of AI-predicted protein complex structures are now available in the #AlphaFold Database.

This spans homodimers from 20 of the most studied species, including humans, as well as the World Health Organization’s priority pathogens list.

www.ebi.ac.uk/about/news/t...

An extra goodie, where we I tried to see whether Pol II clusters (cyan) are placed in pockets of low chromatin content, connecting via low-chromatin channels to NPC-rich export patches. I suppose both is the case.

Acidic pH Restricts Non‐Tuberculous Mycobacteria Replication Different nontuberculous mycobacteria (NTM) species display unique replication profiles in acidic pH in vitro which correlates to their replication within human macrophages. Inhibition of the acidic ...

Very happy to see this out! Great work by @lockwop.bsky.social @crick.ac.uk and first paper on NTMs from the lab! Parise made a set of 12 fluorescently labelled NTMs covering environmental and opportunistic mycobacteria...
onlinelibrary.wiley.com/doi/10.1111/...

👇🏽👇🏽👇🏽👇🏽👇🏽
We often think of cell identity as the result of biochemical signals, soluble or membrane-bound. Join to the @fnucleosome.bsky.social seminar series if you would like to know more on how nanoscale extracellular topography can directly regulate cell identity in embryonic stem cells.

just registered

Deltaviruses spread through a viral Trojan Horse Hepatitis D-like satellite viruses, known as deltaviruses, have been recently discovered in a wide range of animals. These viruses are thought to expr…

The Trojan Horse is real, and it’s microscopic! 🐴🦠
Our paper is out today in @cellcellpress.bsky.social!
We discovered that deltaviruses physically hide INSIDE helper viruses to sneak into new cells. And to prove it, we had to image them from every angle. 🧵👇

www.sciencedirect.com/science/arti...

🚨 Job Alert - Please share! 🙏

Interested in 3D gene regulation in development & evolution? 🤓🧬

💥 Our lab at @cabd-upo-csic.bsky.social is expanding!

We’re recruiting:
✅ PhD students
✅ Postdocs
💻🧪 Experimental or computational backgrounds welcome

👇 Details below

The wonderful historic city of Marburg

🚨 University Marburg (Germany) is recruiting a W2 Professor of Mol. Pharmacology in the Faculty of Medicine.

Focus areas: Epithelial adaptation in #inflammation, #regeneration, and/or #cancer

stellenangebote.uni-marburg.de/jobposting/0...

#AcademicJobs #Pharmacology #FacultyPosition #cellbio

🚨 #postdoc to be hired in the Paluch Lab 🚨

If you know anyone experienced with and, more importantly, excited about nanoscale architecture of #actincortex and super-res & electron #microscopy do encourage them to apply👇

Amazing colleagues, can only recommend 😉

www.cam.ac.uk/jobs/researc...

The Crick to co-lead the Equality, Diversity and Inclusion in Science and Health (EDIS) group The Crick will co-lead the Equality, Diversity and Inclusion in Science and Health (EDIS) group with hosts, the British Science Association, supported by a £10 million grant over seven years from Well...

We’re excited to be working with @britsciassoc.bsky.social to co-lead EDIS, a coalition working to improve equality, diversity and inclusion in science and health research.

Find out more about the plans for EDIS's next chapter ⤵️ www.crick.ac.uk/news/2026-03...

TriRhena Gene Regulation Club Meeting in March 2026.

📍 Location: @igbmc.bsky.social, Strasbourg 🇫🇷
📅 Date: March 18, 2026 | 2:00 PM

🆓 Participation is free of charge, advance registration is required. Register your abstracts for 20-minute research talk.

www.ie-freiburg.mpg.de/gene-regulat...

Final version @nature.com of our paper describing unconventional multicellular development in a choanoflagellate inhabiting an extreme environment. A ton of new data since the first @biorxivpreprint.bsky.social preprint (which we've kept updating).

A brief 🧵 (carried over from the old place)

One week left to register to the Bioimage Analysis with AI course in Pasteur!

This June, 1 - 5.

I give a bit more details in the thread below
👇

Interesting review from the Notani lab on the different functions and regulatory architectures of transcriptional hubs- including #actin; doi.org/10.1016/j.gd...

Finding one mutation that improves a protein is hard. Finding five that work together is exponentially harder.

Today in @science.org, Hsu and Konermann labs present MULTI-evolve, a lab-in-the-loop framework that does it in just one machine learning-guided round.

Actin Counters Geometry to Guide Plant Cell Division - preLights When geometry isn’t enough, actin helps plant cells decide where to divide, ensuring robust tissue patterning

When geometry isn’t enough, actin helps plant cells decide where to divide, ensuring robust tissue patterning. 🌱 #PlantBiology

Goldy & team uncover a central role for F-actin as a cortical landmark.

#preLight by Jeny Jose @umeaplantsciencecentre.se ⬇️ 👀
prelights.biologists.com/highlights/a...

We have an exciting 3-year postdoc position available to study how Salmonella remodels host membrane dynamics.

If you have a background in cell biology and are interested in working on an infection project this could be for you!

Application deadline - 24th February.

www.cam.ac.uk/jobs/researc...

Cdc42 accumulates in aged cells, and reducing its levels extends life span.Two representative WT cells expressing Cdc42-mCherrySW are shown at selected ages and time points (hr: min) from initial loading. White arrowheads indicate cells during or shortly after cytokinesis, when Cdc42 levels are quantified. Black and red arrowheads denote the same cells at other cell cycle stages and cell death, respectively. Scale bar: 3 µm.

Cdc42 is a small GTPase crucial for #CellPolarity, but how does it contribute to #aging when upregulated? This study shows that the ER-anchored chaperone Ydj1 interacts with Cdc42, enhancing its stability & partitioning during asymm #CellDivision & aging in yeast @plosbiology.org 🧪 plos.io/4qz7WaM

The bumpy road leads to the nucleus--cool new mechanobiology!

My lab @cri-utsw.bsky.social is looking for a highly motivated postdoct interested in mechanobiology!

We are building a highly collaborative and interdisciplinary team working on how mechanical forces shape immune and cancer cell behavior.

Come do cool science with me!

lnkd.in/gKEXWUGy

PhD opening
Join a collaborative, interdisciplinary project the Excellence Cluster Future Forests @uni-freiburg.de, working on CRISPR/Cas in poplar to understand how trees cope with climate stress.
Apply here: uni-freiburg.de/en/job/00004...
@dompsfr.bsky.social @biologyunifreiburg.bsky.social

Happy International Day of Women and Girls in Science! 🧪 Don't forget to send in your nominations for the FEBS | EMBO #WomenInScience Award.

Deadline: 15 May

Read more:
www.embo.org/the-embo-communities/feb...
#award