New paper out in EMBO Reports!
We show that Cdc42 regulation is oligomerization-dependent and that a GEF and a GAP act synergistically: Cdc24 relieves self-inhibition of oligomeric Rga2, enabling robust Cdc42 cycling.
doi.org/10.1038/s44319-026-00695-7
#cellpolarity #Cdc42 #synergy #syntheticbiology
Cdc42 accumulates in aged cells, and reducing its levels extends life span.Two representative WT cells expressing Cdc42-mCherrySW are shown at selected ages and time points (hr: min) from initial loading. White arrowheads indicate cells during or shortly after cytokinesis, when Cdc42 levels are quantified. Black and red arrowheads denote the same cells at other cell cycle stages and cell death, respectively. Scale bar: 3 µm.
Cdc42 is a small GTPase crucial for #CellPolarity, but how does it contribute to #aging when upregulated? This study shows that the ER-anchored chaperone Ydj1 interacts with Cdc42, enhancing its stability & partitioning during asymm #CellDivision & aging in yeast @plosbiology.org 🧪 plos.io/4qz7WaM
Cdc42 accumulates in aged cells, and reducing its levels extends life span.Two representative WT cells expressing Cdc42-mCherrySW are shown at selected ages and time points (hr: min) from initial loading. White arrowheads indicate cells during or shortly after cytokinesis, when Cdc42 levels are quantified. Black and red arrowheads denote the same cells at other cell cycle stages and cell death, respectively. Scale bar: 3 µm.
Cdc42 is a small GTPase crucial for #CellPolarity, but how does it contribute to #aging when upregulated? This study shows that the ER-anchored chaperone Ydj1 interacts with Cdc42, enhancing its stability & partitioning during asymm #CellDivision & aging in yeast @plosbiology.org 🧪 plos.io/4qz7WaM
Cdc42 accumulates in aged cells, and reducing its levels extends life span.Two representative WT cells expressing Cdc42-mCherrySW are shown at selected ages and time points (hr: min) from initial loading. White arrowheads indicate cells during or shortly after cytokinesis, when Cdc42 levels are quantified. Black and red arrowheads denote the same cells at other cell cycle stages and cell death, respectively. Scale bar: 3 µm.
Cdc42 is a small GTPase crucial for #CellPolarity, but how does it contribute to #aging when upregulated? This study shows that the ER-anchored chaperone Ydj1 interacts with Cdc42, enhancing its stability & partitioning during asymm #CellDivision & aging in yeast @plosbiology.org 🧪 plos.io/4qz7WaM
🚀 Check out the newly improved Harnos Lab webpages!
Our research on cell polarity, development, and migration - now with a fresh look.
👉 ueb1.sci.muni.cz/ofiz/en/harn...
#CellPolarity #DevelopmentalBiology #Xenopus #WntSignaling
#PDE4DIP activation plays a critical role in #LeftVentricularNoncompaction development by regulating #cellpolarity, skeleton, and energy metabolism via the Rho-ROCK pathway, thereby offering potential targets and therapeutic strategies. #medsky
#OpenAccess:
This study identifies #PDE4DIP as a key player in #LeftVentricularNoncompaction development by regulating #cellpolarity, skeleton, and energy metabolism via the Rho-ROCK pathway. #LVNC
Two cells, one twist 🧬🔁
Myosin asymmetry breaks mirror symmetry & sparks spontaneous 3D rotations in doublets.
Adherens junctions🩶, focal adhesions🟢 & actomyosin🔴 Biology meets active matter physics.
#CellPolarity #Fluorescencefriday #ActiveMatter #Microscopy
Graphical model showing the effect of CASM autophagy in lumen resolution of epithelial tubes.
🧪 Canonical autophagy isn’t enough! In our new study, only CASM can coordinate the membrane remodeling needed to build a single lumen in tubes. Read how CASM drives endocytic recycling to drive morphogenesis www.biorxiv.org/content/10.1...
#ScienceTwitter #Autophagy #Morphogenesis #CellPolarity
Dysfunction of PDE4DIP contributes to LVNC development by regulating cell polarity, skeleton, and energy metabolism via Rho-ROCK pathway
Mechanistic insights into how PDE4DIP contributes to the #pathogenesis of left ventricular non-compaction (#LVNC) by regulating #CellPolarity, cytoskeleton architecture, & energy metabolism through the Rho-ROCK pathway. #cardiomyopathy #medsky
#OpenAccess: www.sciencedirect.com/science/arti...
Introducing #ambassadorISRRWP6 B. Jazmin Reyes H. @bjazminrh.bsky.social
metabolism-dependent Arabidopsis roots dev. and dynamics of microtubules in lateral roots #cellpolarity #SOSEKI proteins #PlantGenetics #Molecular and #CellularBiology #Microscopy Currently in Persson’s lab Uni of Copenhagen
today at noon! #CellPolarity, #CellMigration, #DGZ, #CellBiology
Please join us for the next #DGZ #FocusWorkshop, this time on #CellPolarity and #CellMigration, Jan. 28, noon (CET) via zoom, organized by Virginie Lecaudey and Markus Engstler, featuring talks by James Cleland, Maja Matis, Anton Aebischer & Scott C. Dawson!
Defectos en la organización de la polaridad celular planar pueden participar en la patogénesis del síndrome de uña amarilla congénito y esporádico #yellownailsyndrome #cellpolarity www.acpjournals.org/doi/10.7326/...
Delighted to move over to Bluesky. We are a #CellPolarity
lab using #3Dculture to study how cells collectively move in cancer @cruk-si.bsky.social. Give us a follow if you're into 3D culture, phosphoinositides or metastasis. Strong supporter of equality and helping pull folks up the ladder.
