Advertisement · 728 × 90

Posts by Jim Hurley

Video

📣 Don’t miss our upcoming @mito911.bsky.social #webinar featuring Thomas Melia, PhD, from Yale School of Medicine.

👇 Reserve your spot using the link below.

📅 April 21
⏰ 11:00 AM ET

RSVP: bit.ly/4sfBDiF

6 days ago 2 2 0 0

The application deadline for the 20th FEBS/EMBO Spetses meeting is extended to the 15th March! Please sign up at the link below, or encourage your PhDs and postdocs to come along for what is certain to be a wonderful week!

1 month ago 7 7 0 0
Rearrangement of amphipathic helices enables lipid uptake at ATG2A N-terminus.

Rearrangement of amphipathic helices enables lipid uptake at ATG2A N-terminus.

📢 New #preprint from CRN Team Hurley!

The team uncovers the mechanism of ATG2A-mediated lipid transport 🧪

Structural modeling and simulations show that N-terminal helices gate lipid transfer, and a designed mutant transfers lipids three times faster in vitro.

🔗 bit.ly/3ZVAxw6

1 month ago 10 5 0 0

At #BPS2026? 🧬 Come talk structural biology & mTORC1 signaling!

I'll be at Poster B220 this Tuesday, 2:45–3:45 PM.

I’m also building the Cui Lab at CU Anschutz and looking for postdocs/students interested in Cryo-EM and ML. Let's chat! 🧪🏔️

#Biophysics #CryoEM #StructuralBiology

1 month ago 5 3 0 0

Between this and the recent work from ‪the Wilfling Lab‬
‪@wilflinglab.bsky.social‬ it seems clear that cryo-ET is the new method of choice to study condensation mechanisms.

2 months ago 5 0 0 0
Video

How does molecular valency shape condensate assembly and function? We used the CO2-fixing organelle in algae—the pyrenoid—to find out… 🧵

Preprint here!:
www.biorxiv.org/content/10.6...

@cellarchlab.com @phaips.vd.st @biologyatyork.bsky.social
#Rubisco #PhaseSeparation #Condensates #Pyrenoid

2 months ago 78 37 1 5

Glad to have such great company!

2 months ago 1 0 0 0

I even would go a bit further. This is on a whole different level than anything on the topic up to now.

3 months ago 7 0 1 0
Post image

Seen in the neighborhood: On integrating theory and practice.

3 months ago 7 0 1 0
Preview
Self-renewal of neuronal mitochondria through asymmetric division Mitochondrial ATP production is essential for life. Mitochondrial function depends on the spatio-temporal coordination of nuclear and mitochondrial genome expression, yet how this coordination occurs ...

⚡️Mitochondria make ATP, the energy that powers life. But in neurons, with axons up to a meter long, how do these tiny power plants stay functional in the right places? We went looking. 1/n www.biorxiv.org/content/10.6...

4 months ago 92 43 2 4
Advertisement

So Darwin also discovered the Dunning-Kruger effect, not only natural selection.

4 months ago 2 0 0 0

Alpha Fold predictions: trust but verify (original "доверяй, но проверяй").

4 months ago 12 1 1 0
Preview
Reconstitution of multistep recruitment of ULK1 to membranes in autophagy The ULK1 complex (ULK1C) and the class III phosphatidylinositol 3-kinase complex I (PI3KC3-C1) act together to initiate autophagy. Human ULK1C consists of ULK1 itself, FIP200, and the HORMA domain het...

New pre-print out on the stepwise recruitment to membrane of the #autophagy ULK1 complex from the @mito911.bsky.social from @martenslab.bsky.social Ian Ganley @hummerlab.bsky.social @jimhurley.bsky.social labs
with the generous support of @asapresearch.parkinsonsroadmap.org
doi.org/10.1101/2025...

5 months ago 19 9 0 0
Membrane Dynamics, Repair and Disease | Keystone Symposia Join us at the Keystone Symposia on Membrane Dynamics, Repair and Disease, February 2026, in Keystone, with field leaders!

Membrane dynamics, repair and disease Keystone symposium this February in Colorado. The real, true, final abstract deadline is tonight so the organizers can start picking the short talks tomorrow! www.keystonesymposia.org/conferences/...

5 months ago 2 3 0 0
Post image

Thrilled to join you and Claudine to study the cell's own version of Banksy's self-shredding artwork!

5 months ago 7 3 0 0

Compliance is a lot of work. Hats off to @doroteaartscience.bsky.social for her tireless efforts, and everyone in team @mito911.bsky.social .

5 months ago 6 0 1 0
Post image

Collaborative. Creative. Impactful. Come join us in Ann Arbor! For more information and application link see jobs.sciencecareers.org/job/675674/f...

6 months ago 12 11 0 3
Advertisement
2026 Autophagy in Stress, Development and Disease Conference GRC The 2026 Gordon Research Conference on Autophagy in Stress, Development and Disease will be held in Ventura, California. Apply today to reserve your spot.

Join us in sunny California for the 2026 GRC Autophagy meeting! Excited to co-chair with Oliver Florey and vice chairs Helene Knaevelsrud and @robzonculab.bsky.social
Keynote speakers incl. Eileen White, @idikic.bsky.social and Sharon Tooze- Registration is open: link⬇️ www.grc.org/autophagy-in...

6 months ago 16 10 0 2

Congratulations, Monther!

6 months ago 1 0 0 0

I just saw this in the NYT and now here- congratulations!

6 months ago 1 0 1 0
KSQA: Dr. Dan Baird (Autophagy)
KSQA: Dr. Dan Baird (Autophagy) YouTube video by KeystoneSymposia

Early-career scientists - last call! ⏰ Submit your short talk abstract or scholarship app by Oct 8 (11:59 pm MDT) for Autophagy: Mechanisms to Therapy. Join @annesimonsen.bsky.social, Dan Baird & others!

🔗 keysym.us/KSAutophagy26
🎥 youtu.be/4Y6YvL-unAM

#KSAutophagy26 #autophagy #mitophagy

6 months ago 2 3 0 0
Video

📣 Don't miss out on the upcoming mito911 #webinar featuring Karin Reinisch, PhD, from the Yale School of Medicine.

👇 Reserve your spot using the link below.

📅 October 20
⏰ 11:00 AM ET
RSVP: bit.ly/4gPqCjo

6 months ago 2 1 0 0

Position available! Team @mito911.bsky.social needs a new scientific program manager to take over from legendary super-PM @doroteaartscience.bsky.social, who is moving on to bigger things. This is a Berkeley-based position. Apply at aprecruit.berkeley.edu/JPF05103.

7 months ago 9 8 0 0
Preview
Structural basis for mTORC1 activation on the lysosomal membrane - Nature Cryo-electron microscopy was used to study human mechanistic target of rapamycin complex 1 (mTORC1) activation on lysosomal membranes, showing progressive recruitment by RAG–Ragulator, RHEB and R...

Finally in @nature.com 🎉
We uncovered step-wise mTORC1 activation on membrane: RAG–Ragulator recruits, RHEB pushes closer, and direct membrane contacts by RAPTOR + mTOR trigger full kinase activity.👉 The membrane is not just a platform — it’s part of the mechanism.
www.nature.com/articles/s41...

7 months ago 35 14 5 2

Thanks, Brett. @chen3dem.bsky.social did an incredible job, and everything came together.

7 months ago 2 0 0 0
Advertisement

RFK Jr. rolled out that old chestnut again about how healthy Americans were in the 60’s, so here’s a fact check.

In 1965:

-42% of American adults smoked; it’s 11% now.

-The infant morality rate was 24.7/1000; it’s 5.6/1000 now.

-Overall life expectancy was 70 years; it's about 77 years now.

7 months ago 18472 6833 743 317

Congratulations (even if it is hardly a surprise!)

7 months ago 1 0 1 0
Video

📣 Don't miss out on the upcoming @mito911.bsky.social webinar featuring Katie Drerup, PhD, from the University of Wisconsin.

👇 Reserve your spot using the link below.

📅 September 8
⏰ 11:00 AM EST
RSVP: bit.ly/4mUJeAc

7 months ago 3 4 0 0

🧪 And House appropriators say: no cuts to NIH budget!

House subcommittee version just came out (link below). Holds NIH flat at $48 billion.

To be clear: this is far from over. But a good sign that science still matters across both sides of aisle.

YOUR VOICE MATTERS!!

7 months ago 465 178 5 12
Video

BREAKING: Big moment as CDC staff stage a mass walkout.

They have lined the street outside its HQ to greet and salute the four top officials who have resigned in protest at RFK Jr’s attack on the agency’s science base.

(🎥 AP)

7 months ago 10535 3393 168 246