The evolution of high-order genome architecture revealed from 1,000 species Comparative Hi-C analysis across 1,025 species reveals that genome architecture has evolved along distinct trajectories, with plants favoring global folding and animals developing checkerboard compart...

The #evolution of high-order #genome architecture revealed from 1,000 #species: Cell www.cell.com/cell/fulltex...

Sex effects on gene expression across the human cerebral cortex at cell type resolution Sex differences in neurodevelopmental, psychiatric, and neurodegenerative disease susceptibility may arise from sex chromosome and hormonal influences on cell type–specific gene expression. We present...

#Sex effects on #gene expression across the #human cerebral #cortex at #cell type resolution | Science www.science.org/doi/10.1126/...

Genomic approaches for understanding the evolution of the human brain - Nature Neuroscience This Review describes how an approach that starts from genetic changes under selection during human evolution and integrates comparative and functional studies can reveal adaptive phenotypes across di...

#Genomic approaches for understanding the #evolution of the #human #brain
doi.org/10.1038/s415...

The media’s failure to cover Trump’s son-in-law Jared Kushner’s ongoing conflicts of interest as he gets billions from the Middle East while being Trump’s negotiator is insane.

(Especially after what they did with Hunter Biden)

popular.info/p/the-media-...

To be fair, academics are mostly obsessed with flagellating their colleagues, not their actual selves.

An opposing molecular gradient axis underlies primate cortical organization The principles organizing cellular diversity and connectivity in primate brains remain elusive. By integrating spatial transcriptomics, magnetic resonance imaging, and retrograde labeling in marmosets...

An opposing #molecular gradient axis underlies #primate #cortical organization | Science www.science.org/doi/10.1126/...

Cool! This group basically did what Carandini/Harris lab did for V1 back in 2022, but for HPC. Interestingly, it is tPC2, instead of tPC1 that is the axis this time.

A #transcriptomic axis aligns with in vivo functional dynamics in #hippocampal #inhibitory #circuits
doi.org/10.64898/202...

Light can evaporate water in the absence of heat

Can light evaporate water? Science says yes! We all know that heat evaporates water, but a recent study by @MIT
researchers has shown that photons can do the same.

A thread

An illustration of an apical region of an animal cell in cross section, shown crowded with individual molecules. The plasma membrane is densely occupied by influenza virus glycoproteins, and from the surface bud influenza virions with different morphologies (L-R): spherical, bacilliform, filamentous with a genome, filamentous and empty, filamentous with a helical inner layer, and filamentous with a cofilactin cytoskeleton.

🚨New pre-print!🚨
Because influenza virions are highly variable in form no single method can show their molecular architecture in detail. Here, we integrate multiple structural and compositional approaches to identify new features of these beautiful virus particles
www.biorxiv.org/content/10.6...

Sex effects on gene expression across the human cerebral cortex at cell type resolution
www.science.org/doi/10.1126/...

Beautiful work!

Wow, very beautiful work!

Just published in @science.org 🚀

By controlling how cells align, we show that living nematic tissues can be programmed to generate forces and fold into predictable 3D shapes.

A new platform for tissue engineering and the design of smart active materials! 🫆

www.science.org/doi/10.1126/...

Categorization is ‘baked’ into the brain - Nature Reviews Neuroscience Categorization, the grouping of objects, living organisms, actions or events into equivalence clusters, is fundamental to adaptive behaviour. In this Perspective, Barrett and Miller discuss evidence t...

Categorization is ‘baked’ into the brain — a Perspective by Lisa Feldman Barrett & Earl K. Miller

@lisafeldmanbarrett.com @earlkmiller.bsky.social

#neuroscience #neuroskyence

www.nature.com/articles/s41...

Ancient DNA reveals pervasive directional selection across West Eurasia - Nature Analysis of 15,836 ancient West Eurasian genomes reveals hundreds of instances of directional selection, showing that sustained changes in allele frequency were widespread, rather than being rare over this period as previously assumed.

Nature research paper: Ancient DNA reveals pervasive directional selection across West Eurasia

go.nature.com/485gakC

Electromagnetic field-inducible in vivo gene switch for remote spatiotemporal control of gene expression The EMF-inducible gene switch (Ei) platform provides precise spatiotemporal control of gene expression through Cyb5b-mediated calcium oscillations. This system enables Ei-OSK-driven in vivo rejuvenati...

Cool Cell pub. Korean team report finding EMF sensor Cyb5b & use it to make inducible gene expression system. Essentially remote-controlled EMF-driven mouse model. They use this including for OSK in vivo reprogramming. www.cell.com/cell/abstrac... Makes you wonder about human EMF exposure!

Holy shit, this is really happening in my lifetime.

The neural mechanisms supporting the rise and fall of maternal aggression - Nature In mice, female aggression is governed by an amygdala–to–medial hypothalamus circuit that is strengthened during pregnancy and is dynamically amplified by oxytocin during lactation.

What has changed in mama bear brain (well, actually mice) to make her risk her life to attack a potential threat and protect her young? Oxytocin is the key! Happy to share our new study led by two awesome postdocs: Takashi Yamaguchi and Rongzhen Yan.
www.nature.com/articles/s41...

The supply of blood to brain tissue is thought to depend on the overall neural activity in that tissue, and this dependence is thought to differ across brain regions and across brain states. However, studies supporting these views have measured neural activity as a bulk quantity and related it to blood supply following disparate events in different regions. Here we measure fluctuations in neuronal activity and blood volume across the mouse brain, and find that their relationship is consistent across brain states and brain regions but differs in two opposing brainwide neural populations. Functional ultrasound imaging (fUSI) revealed that whisking, a marker of arousal, is associated with brainwide fluctuations in blood volume. Simultaneous fUSI and Neuropixels recordings showed that neurons that increase activity with whisking have distinct haemodynamic response functions compared with those that decrease activity. Their summed contributions predicted blood volume across states.Brainwide Neuropixels recordings revealed that these opposing populations coexist in the entire brain. Their differing contributions to blood volume largely explain the apparent differences in blood volume fluctuations across regions. The mouse brain thus contains two neural populations with opposite relations to brain state and distinct relationships to blood supply, which together account for brainwide fluctuations in blood volume.

How does blood flow relate to brain activity? We discovered that it reflects two neural populations affected oppositely by arousal. Together, they explain neurovascular coupling in all brain regions and brain states!

Out today in Nature: rdcu.be/fdC2A

@uclbrainscience.bsky.social

For nearly a century, we believed the therapeutic effect of ECT is the seizure. Our latest research suggests we may have been looking at the wrong event.
A thread on why cortical spreading depression (CSD) might be the driver of therapeutic benefit.
Work led by @therehugolad.bsky.social

Experimental design. Top left: Representations of (conceptual) space may benefit from the integration of action affordances, e.g., in a game of chess, where information about how pieces can move is necessary to play the game. The authors tested this idea using numerical operations, whereby participants moved between numbers following the rules of an underlying graph structure. Top right: Participants learned how numbers may ‘transform’ into other numbers using an exploration task, whereby they were presented with an individual number and were offered a free choice of two possible successors. When a successor was chosen, the next trial offered the successors for the chosen number. In interleaved test blocks, participants indicated which were the ‘correct’ successors for each number. In the eyetracker and fMRI scanner, individual numbers were presented in a pseudorandom order. Bottom: Unbeknownst to participants, number-action bindings formed part of a repeating sequence arranged in graph ‘modules’ of four numbers. This can be seen as a set of four states with the same action affordances, projected on a number line. In the example presented, numbers 21 and 26 correspond to state 1 (‘S1’; and therefore also 31, 36, etc.), but this was assigned differently to each participant. As the modules repeated every five numbers, the structure allowed easy inference of action possibilities for any new numbers.

How do we navigate our #memory maps of spatial & non-spatial experience? This study shows that the #EntorhinalCortex not only encodes the structure of experience, but also actions in conceptual space, and these representations are reflected in #gaze behavior @plosbiology.org 🧪 plos.io/4czCPHk

Differential changes in structure–function coupling and decoupling with aging in the main dataset. Longitudinal effects were estimated using linear mixed-effects models, with fixed coefficients (β) representing the effect of time interval from the first scan. Spaghetti plots (left: salience network A, SN-A. Right: Default mode network A, SMN-A) display individual trajectories of structure–function coupling and decoupling over time, adjusted for baseline age, gender, and education. Coupling and decoupling measures were computed using K values explaining 95% of variance, shown here for illustration; similar results were observed with 80% and 90% variance thresholds. Asterisks (*) indicate effects that survived Bonferroni correction for multiple comparisons (α = 0.05/16 ≈ 0.003).

#Aging alters how the structural wiring of the #brain constrains its functional activity. This study reveals how changes in this balance, particularly within the #SalienceNetwork, predict declines in #CognitiveFlexibility over time @plosbiology.org 🧪 plos.io/4tTlNei

ASI-Evolve Outperformed Human Researchers.. In Architecture, Data, and Algorithms And the system was never told what to prioritize.

ASI-Evolve Outperformed Human Researchers.. In Architecture, Data, and Algorithms ninza7.medium.com/asi-evolve-o...

Mapping nerves in a whole embryos.

We find that across species and development stages, embryonic nerves display (beautiful) fractal geometry.

More here: www.biorxiv.org/content/10.6...

Quantum mechanics has gone from a theory in test to becoming the foundation of new technologies.

Learn more in a 2025 #SciencePerspective that looked at 100 years of quantum mechanics: https://scim.ag/3Qvgi6M

High glucose impairs cognitive function through Creb3 O-GlcNAcylation and increased lactate production Targeting a transcriptional pathway in hippocampal neurons may preserve cognitive function in patients with diabetes.

High glucose impairs cognitive function through Creb3 O-GlcNAcylation and increased lactate production | Science Signaling www.science.org/doi/10.1126/...

Practical optimization for three-photon microscopy to allow larger field of view and faster calcium imaging (10-30 Hz)
www.biorxiv.org/content/10.6...

Physicist has written a fascinating big beautiful paper.Let’s not be afraid to call it what it is - groundbreaking.

arxiv.org/abs/2603.21852

Rapid concerted switching of the neural code in the inferotemporal cortex - Nature Face cells in the macaque inferotemporal cortex are initially able to detect faces and then rapidly switch to a face-specific neural code to discriminate between different face identities.

"Rapid concerted switching of the neural code in the inferotemporal cortex" 🧠😊

Exciting new work in Nature led by Yuelin Shi with Doris Tsao

www.nature.com/articles/s41...

#neuroskyence #faces

Congratulations @shkwon-bcmbneuro.bsky.social !