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Posts by Mattia Laffranchi

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πŸ‘‰ Save the date!

SIICA announces the Virtual School of Immunology 2026, an online event open to anyone interested in gaining a deeper understanding of how the immune system works.

πŸŽ™οΈExpert talks
πŸ’Ό A dedicated career-development workshop session

✍️ More details coming soon!

4 months ago 8 6 1 0
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πŸ“£ Save the date!

πŸ”Ή Breaking the Maternal Wall | Panel Discussion

πŸ—“ Jan 14 | πŸ•‘ 14:00 CET
πŸŽ™οΈ Motherhood & careers in science, academia & industry

πŸ“ Register: tinyurl.com/yefis2026-ia1

3 months ago 4 4 1 2
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Aroca-CrevillΓ©n, Hidalgo @drusqui.bsky.social et al. identify a #circadian checkpoint in #neutrophils, mediated by the CXCL12–CXCR4 axis, that limits tissue injury by inhibiting their intrinsic circadian clock. rupress.org/jem/article/...

#CardiovascularBiology #InnateImmunity #inflammation

4 months ago 2 1 0 0

The deadline is approaching! Apply for a PhD position in our group!

4 months ago 2 2 0 0

πŸ“’ Calling all early-career immunologists!

Are you passionate about #science-communication, #outreach and #editorial-strategy? The yEFIS-EJI working group is looking for you! 🫡

We’re recruiting motivated ECRs to contribute to editorial processes and creating content on yEFIS ECR activities ✍️

6 months ago 8 4 1 2
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⏳ Spring School: The registration deadline has been extended to 23 November! dgfi.org/akademie-fue...
About the DGfI-Spring School on Immunology
dgfi.org/akademie-fue...
@iuis-online.bsky.social @iuisjuniorcomm.bsky.social @dgfi-yi.bsky.social @drfzberlin.bsky.social

5 months ago 4 4 0 0

Congratulations to the new #yEFIS BoardπŸ‘
Looking forward to working together on exciting projects and initiatives πŸ™Œ
#EFIS #Immunology
@yefis-immunology.bsky.social

4 months ago 5 1 0 0
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Join the yEFIS task force 2025-2026 Are you interested in joining the yEFIS adventure? You want to join existing working groups or have a new idea you'd like to implement? or even create a young immunology society in your own country? ...

If you’re passionate about shaping the future of the ECR community, join the yEFIS Task Force and get involved!
πŸ‘‰ docs.google.com/forms/d/e/1F...

4 months ago 4 4 1 0
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Check out:

Unveiling a novel NBAS mutation in common variable immunodeficiency: Expanding the genetic landscape of immunodeficiency disorders

doi.org/10.1016/j.im...

Novel association between NBAS gene and Common variable immunodeficiency (CVID) syndrome

#immunodeficiency #gene #immunobiology

4 months ago 0 0 0 0
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Check out:

Increased co-expression of ICOS and PD-1 predicts poor overall survival in patients with acute myeloid leukemia

doi.org/10.1016/j.im...

High expression of ICOS was associated with poor outcomes in AML patients, with implications for novel AML therapies

#leukemia #ICB #immunobiology

5 months ago 0 0 0 0
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A myeloid Tet2-IL-1Ξ² axis modulates intestinal inflammation by restricting catecholaminergic stimulation of enterochromaffin cell differentiation Using a mouse model that selectively lacks TET2 in myeloid cells, Sharma et al. show that myeloid cells and sympathetic neurons form a signaling nexus that controls serotonin production by enterochromaffin cells, which modulates colonic inflammation. Further, physiological stress uses sympathetic cues to drive serotonin production and worsen colitis.
5 months ago 1 1 0 0
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πŸš€ One week until the #EFIS on Tour Symposium lands in Bucharest, πŸ‡·πŸ‡΄
🀝 Chance to meet the EFIS Board and network w/ colleagues across Europe
βœ… Finalize registration today via QR code
πŸ“… November 14, 2025 at 13:00

#immunology
@yefis-immunology.bsky.social @hammarieke.bsky.social @bojanpolic.bsky.social

5 months ago 3 3 0 1
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Still think this was one of the best power moves of all time

www.sciencedirect.com/science/arti...

5 months ago 317 65 8 9
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πŸ“’ We're SO EXCITED to host Prof. Jean-Laurent Casanova (@casanovalab.bsky.social) for our upcoming YI Seminar. If you're someone excited about the the human genetics of infectious diseases, this ain't a seminar you should miss! Do register at shorturl.at/J6gPh

5 months ago 8 5 2 1
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Check out:

Altered serum concentrations of IL-8, IL-32 and IL-10 in patients with lung impairment 6 months after COVID-19

doi.org/10.1016/j.im...

Serum IL-32, IL-8, and IL-10 levels are associated to lung sequelae after COVID-19.

#COVID-19 #cytokine #immunology #immunobiology

5 months ago 0 0 0 0
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A computational method designs receptors called T-SenSERs, which have predictable signalling responses to tumour microenvironment soluble factors and can be co-expressed with conventional CARs in T cells to enhance their therapeutic activity.
www.nature.com/articles/s41...

5 months ago 6 4 0 0

Exciting #postdoc opportunity in KL Ung's group!
Understanding the molecular mechanisms of cell wall remodeling in pathogens

Learn more: shorturl.at/gPuFV
Deadline: January 15, 2026
Contact: recruit@ipbs.fr
#Protein #Biochemistry #StructuralBiology #Biophysics #CryoEM

5 months ago 6 10 0 0
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Early-life Immune Imprinting and Inflammatory Diseases - IPBS-Toulouse Our team studies neonatal immunity. We are particularly interested in mapping the mucosal cell subsets[…]

Exciting #postdoc opportunity in T. Gensollen's group!
How early-life interactions between the immune system and microbiota shape lifelong immune imprinting and disease risk
Learn more: shorturl.at/F8hqE
Deadline: January 15, 2026
Contact: recruit@ipbs.fr
#Immunology #Microbiology #Microbiota #Omics

5 months ago 4 4 0 0
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Still relevant in Immunology:

Macrophages: Their role, activation and polarization in pulmonary diseases
www.sciencedirect.com/science/arti...

Key points:
The diverse functions of lung macrophages are attributable to their plasticity

#Macrophage #Immunology #Immunobiology #Elsevier

5 months ago 0 0 0 0
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Check out our latest review on dendritic cells and their roles in cancer immune responses on Cellular & Molecular Immunology:

"Dendritic cell subsets in cancer immunity and tumor antigen sensing"
doi.org/10.1038/s414...

#science #immunology #review #dendriticcell #DC #immunesystem #cancer

6 months ago 0 0 0 0
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Pancreatic cancer relies on opposing signalling pathways to drive its cellular diversity Communication between epithelial and mesenchymal cells in pancreatic cancer leads to a poor prognosis. The molecular basis for this signalling has now been revealed.

The molecular basis for signalling between epithelial and mesenchymal cells in pancreatic cancer has now been revealed

go.nature.com/3Jlu490

6 months ago 40 17 1 0
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The phenotype and related gene expressions of macrophages in adipose tissue of T2D mice following MSCs infusion Infusion of mesenchymal stem cells (MSCs) induces polarization of M2 macrophages in adipose tissue of type 2 diabetes (T2D) mice. Studies have shown t…

Check out:

The phenotype and related gene expressions of macrophages in adipose tissue of T2D mice following MSCs infusion

Key point:
Mesenchymal stem cells induces an M2-like state in macrophages in adipose tissue.

www.sciencedirect.com/science/arti...
#immunology #macrophages #science #elsevier

6 months ago 1 0 0 0
RNA velocity in situ infers gene expression dynamics using spatial transcriptomics data
RNA velocity in situ infers gene expression dynamics using spatial transcriptomics data YouTube video by Prof. Jean Fan

What is RNA velocity in situ? ChatGPT kept getting it wrong...

So I made this video explaining how RNA velocity in situ infers gene expression dynamics by distinguishing nuclear vs. cytoplasmic expression in spatial transcriptomics data: youtu.be/z9Oxf1hvum0

#AcademicSky

6 months ago 26 8 2 1

Amazing to have our work finally out!!! 😍🀩😍

6 months ago 36 7 1 0
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Check out:

Single-cell transcriptome analysis of macrophage subpopulations contributing to chemotherapy resistance in ovarian cancer
Key points:
macrophaged increased their frequency post-chemotherapy in ovarian cancers

www.sciencedirect.com/science/arti...
#Immunology #Immunobiology #Elsevier

6 months ago 0 0 0 0
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Still relevant in Immunology:

Natural and trained innate immunity against Mycobacterium tuberculosis
www.sciencedirect.com/science/arti...

Key points:
M. Tuberculosis and BCG vaccine creates trained immune memory via TLR7/9 signaling.

#Tubercolosis #Vaccine #Immunology #Immunobiology #Elsevier

6 months ago 0 0 0 0
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Check out one of our latest review on Chemerin (RARRES2) and it's roles in the regulation of immune responses on Journal of Leukocyte Biology.

doi.org/10.1093/jleu...

#science #immunology #review #chemerin #immunesystem

7 months ago 0 0 0 0
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Still relevant in Immunology:

Human macrophage polarization in vitro: Maturation and activation methods compared

Key points:
Macrophage polarization is highly dependent on environmental factors.

www.sciencedirect.com/science/arti...

#Science #Immunology #Macrophage #Immunobiology #Elsevier

7 months ago 2 0 0 0