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Posts by David B. Sauer

Introduction to Statistics for the Life Sciences (online training). Available from 27 April 2026, register online. Includes Biochemical Society logo and image of scientists around a laptop

Introduction to Statistics for the Life Sciences (online training). Available from 27 April 2026, register online. Includes Biochemical Society logo and image of scientists around a laptop

Starting 27 April 2026, our online Introduction to Statistics for the Life Sciences course helps you build confidence in data analysis and strengthen your research skills. Enrol today and study at your own pace: ow.ly/xuxT50YAvtN

4 days ago 0 2 0 0
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Starting 27 April 2026, our online Introduction to Statistics for the Life Sciences course helps you build confidence in data analysis and strengthen your research skills. Enrol today and study at your own pace: https://ow.ly/xuxT50YAvtN

6 days ago 1 2 0 0
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Postdoctoral Position in Membrane Protein Biology & Ion Channel Physiology Post a job in 3min, or find thousands of job offers like this one at jobRxiv!

We’re hiring! Our group at CSHL has openings for postdoctoral fellows in structural biology with a focus on ion channels and receptors in neurotransmission and cancer immunology. Join and pursue unique, cross-disciplinary science to boost your career. jobrxiv.org/job/cold-spr...

2 weeks ago 7 9 0 0

Are you excited by virology? Would you like to do a PhD? Three fantastic opportunities are available to do joint PhDs between @cvrinfo.bsky.social and @pirbrightinst.bsky.social
Details in the thread below - please share!
Deadline 8th May 2026, fully funded for UK Home students
(1/4)

2 weeks ago 12 20 1 0
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PDB101: Register for the April 30 CodeBMB Webinar for Beginners PDB-101: Training, Outreach, and Education portal of RCSB PDB

Register for the April 30 CodeBMB Webinar for
- Scientists in the biosciences starting to code
- Post-docs and graduate students who want to bring coding into their learning
- Instructors involved in Biochemistry and Molecular Biology Education

3 weeks ago 4 4 0 0
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I’m recruiting!

I'm excited to share a new 4-year fully funded Leverhulme Trust PhD studentship to define the rules governing membrane protein folding.

www.findaphd.com/phds/project...

Advert closes 1st June for a 1st October start.

Please reach out for more info!

PDRA ad (4 years) to follow!

1 month ago 5 4 0 0
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Protocol for stable cell line production to express muscle-type nicotinic receptor The adult muscle-type nicotinic acetylcholine receptor (AChR) is essential for neuromuscular transmission but is difficult to produce due to the requirement for coordinated subunit assembly. Here, we ...

Step-by-step protocol to make stable cell lines for large-scale expression of muscle-type nAChR (and other multi-subunit targets)!

By the inexhaustible and tenacious @annaliiiiiiii.bsky.social in collab with Dong group in #MRCWIMM and @cmd.ox.ac.uk

www.cell.com/star-protoco...

1 month ago 3 0 0 0
Scientists in lab coats engaged in hands-on training. Promoting the 7th UK Workshop on Membrane Proteins in Birmingham, UK
15-17 April 2026.

Scientists in lab coats engaged in hands-on training. Promoting the 7th UK Workshop on Membrane Proteins in Birmingham, UK 15-17 April 2026.

Limited places remaining! Join the 7th UK Workshop on Membrane Proteins for lectures, workshops & hands-on lab training in purification and biophysical techniques. Secure your place now! Register here: https://ow.ly/zkVT50YrcNC

1 month ago 2 3 0 0
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Come work with Ben Berks FRS in Oxford
2 x PDRA posts: Molecular Analysis of Bacterial Outer Membrane Protein Biogenesis

2 complementary projects investigating bacterial outer membrane protein biogenesis. Building on our recent work (Nature (2015) 647: 479-487)

my.corehr.com/pls/uoxrecru...

1 month ago 15 17 1 1
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A wonderful first for me at the upcoming @biophysicalsoc.bsky.social meeting in SF is having many lab members present! See 6 brilliant graduate students postdocs from the lab present talks and posters on how they are pushing the boundaries of technology and mechanistic membrane protein biology

2 months ago 15 4 1 0
Amino acid and viral binding by the high-affinity Cationic Amino acid Transporter 1 (CAT1) from Mus musculus - Nature Communications Cationic amino acids are essential to protein synthesis and cellular signaling. Here, authors determine the structure of the cationic amino acid transporter 1 and determined how it is co-opted as a re...

Our study of the CAT1 amino acid transporter and viral receptor is now online in @natcomms.nature.com!

Spearheaded by the incredibly talented @mingda-ye.bsky.social with colleagues from @cmd.ox.ac.uk, Strubi, CAMS Oxford Institute, @ndm.ox.ac.uk, and supported by the IM2PACT consortium.

2 months ago 5 3 0 0
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Stories from the scientist who changed how we visualize proteins - Nature Reviews Chemistry Ahead of her 85th birthday, Jane Richardson, Professor of Biochemistry at Duke University, discussed her life in science from making her own telescope to developing the ribbon diagrams for the 3D stru...

Stories from #WomenInScience who changed how we visualize #proteins: Ahead of her 85th birthday, Jane Richardson (Duke Univ, @biophysicalsoc.bsky.social president 2012-13) discussed her life from making a telescope to developing ribbon diagrams for 3D protein structure www.nature.com/articles/s41...

2 months ago 26 10 0 1

Join @naomilpollock.bsky.social, @alangoddard.bsky.social & @alice-rothnie.bsky.social from 15-17 April to understand the basics of membrane protein purification using cutting edge methods, at the 7th UK Workshop on Membrane #Proteins! Places are limited, save £50 if you register before 15 February!

2 months ago 3 3 0 0
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Congenital myasthenic syndrome: is it time for a name change to genetic myasthenic syndrome? Ramdas et al. propose renaming ‘congenital myasthenic syndrome’ as ‘genetic myasthenic syndrome’. They argue that ‘congenital’ misleadingly implies neonata

#WIMMReads 🧪

#MRCWIMM Group Leader Yin Dong is among clinicians and scientists with expertise in congenital #MyasthenicSyndrome suggesting it may be time to update the disease name to reduce misdiagnosis and improve care.
#Neurology #RareDisease

@ndcnoxford.bsky.social @medsci.ox.ac.uk

2 months ago 5 4 0 0
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Celebrating another paper acceptance for the group! @cmd.ox.ac.uk

Congrats to this stellar team!

2 months ago 2 0 1 0
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Time to sign up!

Registration for the joint FEBS/EMBO course on ion channels and transporters in Erice, Italy (May 13-19th 2026) is now open:
meetings.embo.org/event/26-ion...

Please share and repost.

3 months ago 13 11 1 0

I've reviewed about 150 CVs in the past few days. A few observations: (1) I am sooo impressed by the talent pool out there; (2) do not try to make your CV fit onto one page if it makes things difficult to read - just go multipage, keeping the key messages upfront;

3 months ago 13 4 2 1

Gave my annual "State of the Group" talk at lab meeting
- 6 Papers published
- 3 Manuscripts in review
- 4 Grants funded
- New research directions and international collaborations

Immensely proud of all our team accomplished in 2025, and excited to share our new results in 2026!

3 months ago 1 0 1 0
PNAS – Honoring the life of David John “Davo” Mangelsdorf. A life of science, friendship, and joy.

PNAS – Honoring the life of David John “Davo” Mangelsdorf. A life of science, friendship, and joy.

PNAS honors the life of David John “Davo” Mangelsdorf—whose groundbreaking discoveries reshaped nuclear receptor and metabolic biology. Remembered not only for his science, but for his generosity and mentorship. Read more: https://ow.ly/1c8050XUcS8

3 months ago 3 2 0 0
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Structural basis of sodium ion-dependent carnitine transport by OCTN2 Nature Communications - Carnitine uptake by OCTN2 supports fatty acid metabolism. Here, authors report cryo-EM structures of human OCTN2, revealing the mechanism of sodium ion-dependent carnitine...

Our paper on the human carnitine transporter OCTN2 (SLC22A5) is out in @natcomms.nature.com! We solved structures of OCTN2 in multiple states and explored how carnitine transport is Na⁺-dependent, providing a framework for understanding SPCD disease causing variants and drug interactions.

3 months ago 17 9 1 0
(Top) smFRET enables direct observation of a sodium-coupled transporter executing rapid, stochastic elevator-type motions in lipid bilayers. (Bottom) Thermodynamic modeling shows how highly cooperative co-substrate binding enables tightly coupled transport, without suppressing these motions.

(Top) smFRET enables direct observation of a sodium-coupled transporter executing rapid, stochastic elevator-type motions in lipid bilayers. (Bottom) Thermodynamic modeling shows how highly cooperative co-substrate binding enables tightly coupled transport, without suppressing these motions.

New work out today in PNAS!

Secondary active transporters are everywhere, but direct observation of their structural dynamics is rarely achieved.

Here, we capture the real-time dynamics of a sodium-coupled dicarboxylate transporter using smFRET.

🧵⬇️
doi.org/10.1073/pnas...

3 months ago 14 1 1 0
PNAS Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

A deep dive into the conformational dynamics and substrate coupling of VcINDY!

A huge collab of @rubenlgonzalez.bsky.social, Colin D. Kinz-Thompson, @danengw.bsky.social, @chrismulligan.bsky.social, Joe Mindell, David Stokes and many others

doi.org/10.1073/pnas...

3 months ago 2 0 0 0
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The Gonzalez Lab at Columbia University is seeking a scientific leader!

Join us in a Research Scientist position, driving single-molecule, structural, and biochemical studies of translation, translational control, and other RNA-based processes.

Apply: apply.interfolio.com/176949

4 months ago 12 18 0 0
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Christmas 2025 party with (some) of our amazing membrane protein team @cmd.ox.ac.uk

4 months ago 6 0 0 0
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#ScientistSpotlight
This week we’re introducing Anna Li, a postdoctoral researcher in the Yin Dong Lab at the #MRCWIMM.

@ndcnoxford.bsky.social @medsci.ox.ac.uk

#WIMMSpotlight #WIMMCommunity #StructuralBiology #CryoEM #IonChannels #Neuroscience

Photo credit: Susan Maxwell

4 months ago 4 2 1 0

A fascinating story on the history and complexity of T-cell migration by Susan Schwab! #NYUGrossman #NYULangone

www.youtube.com/watch?v=zPHN...

4 months ago 2 0 0 0
Structural basis of specific lysine transport by Pseudomonas aeruginosa permease LysP - Nature Communications Pseudomonas aeruginosa survives extreme acidity by importing lysine through the LysP transporter to regulate acid-resistance genes. Here, authors reveal the cryo-EM structure of LysP and show how spec...

The LysP structure is published! Congrats to Emmanuel Nji and colleagues!

www.nature.com/articles/s41...

4 months ago 2 0 0 0
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Paper accepted!!!

4 months ago 2 0 0 0

It’s great to see people thinking about tracking errors in Fourier terms! EM_placement tries to infer effects of orientation bias from half maps, but it would be far better to do this directly in the reconstruction process. No surprise it’s people like ZO and Dominika doing this work!

4 months ago 4 3 0 0

Anyone know if I can submit a bug report to Toyota? Seems like an easy software fix.

4 months ago 0 0 0 0
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