Thrilled to share our work in
@cp-immunity.bsky.social: "Resident Memory T cells in Primates Activate Humoral and Stromal Immunity." Thanks @cfi-umn.bsky.social @vgti.bsky.social @enprcnews.bsky.social, outstanding Masopust lab members and Dave Masopust!
authors.elsevier.com/c/1lxK43qNrU...

Research Scientist I - Carbone Lab in Seattle, Washington | Research at Seattle Children's Apply for Research Scientist I - Carbone Lab job with Seattle Children's in Seattle, Washington. Research at Seattle Children's

🔬 The Carbone Lab is Hiring! 🔬

I'm looking for a Research Scientist I to help launch my new lab at Seattle Children's Research Institute! If you or someone you know is excited about #cancerimmunology, #microscopy, and building a lab from the ground up, apply here:

Facilities and Administrative (F&A) Costs Explainer YouTube video by Association of American Universities

Make sure you, your trainees, and anyone else who might listen to you understands what "indirects" actually are, how they are established, and what Universities contribute. H/T @rodallab.bsky.social

Please share widely!

www.youtube.com/watch?v=yxTD...

Congresswoman Lizzie Fletcher on Trump Administration Cuts to Medical Research Washington, D.C.—Today, Congresswoman Lizzie Fletcher (TX-07) released the following statement in response to the Trump administration’s announced policy to cap indirect costs for National Institutes of Health (NIH) research grants: “Houston is home to the largest medical complex in the world, where cutting-edge medical research takes place and saves lives. For decades, Houston’s medical institutions have been leaders in scientific breakthroughs because of a partnership with the federal government and federal investments in medical and scientific research. And the United States has led the world because of its partnerships with institutions here in Houston and across the country that do this important work. “The Trump administration’s cuts to NIH research grant funding jeopardize so much of the work we are so proud to do here. There is no doubt that these caps will lead to the elimination of jobs in medical and research fields, halt critical research, and delay advancements in the treatments of diseases ranging from cancer to Alzheimer’s to rare genetic disorders. We cannot afford to turn our backs on the researchers who dedicate their lives to medical progress or to their important work. And we cannot allow the Trump administration to ignore Congress’ funding directives or the contracts already in place between the government and our research institutions. I will continue fighting to restore and protect NIH funding so that Houston remains at the forefront of global medical innovation.”

The Trump administration’s announced policy to cut funding for medical research grants from the National Institutes of Health (NIH) is terrible for #TX07 and for our country. My statement ⬇️

the yield on NIH research for economic activity

How to get 146% return on investment?
The NIH. That's just the economic benefit.
Biomedical research promotes human health.

NIH slashes overhead payments for research, sparking outrage Move to cut indirect cost rate to 15% could cost universities billions of dollars

News reports on NIH cutting indirect costs may not be understood by many not dealing with science funding.

To do science, you need to apply for funding. This has becomer a highly competative process. Many good ideas are not funded due to a shortage of money.

www.science.org/cont...
1/9

This is a list of blockbuster drugs in 2024. Guess how many can trace their origins to NIH funded research?
All of them.

A quick reminder: For every $1 of research funding, NIH generated $2.46 in economic activity. This includes funding jobs in all 50 states. This isn't a red/blue thing: 8.9 jobs per $1M in CA & 12 jobs per $1M in GA. #AcademicSky #PhDSky #MedSky #HealthSky #healthequity #SciComm
bit.ly/40NkIc0

No functional NIH…no US scientists that spend their days making discoveries that save lives and drive US innovation and economic growth. This will negatively impact all Americans.

Trump hits NIH with ‘devastating’ freezes on meetings, travel, communications, and hiring Researchers facing

To all of my colleagues at NIH, I'm thinking of you and I'm sending all the good vibes I can muster!!! To all of my other colleagues as panicked as I am about the NIH funding that allows us to do the important research we do... We'll get through this together, somehow www.science.org/content/arti...

Thank you! and yours as well!

Thank you!

Special thanks to my PhD mentor Rafi, my co-first author, Rajesh Valanparambil, and all the rest of our co-authors.

Image above shows CD8 T cells asking a crystal ball to predict infection outcome. Credit: ChatGPT4

Also see our companion paper from Dietmar Zehn's lab: tinyurl.com/yck3mdup

Tissue-resident memory CD8 T cell diversity is spatiotemporally imprinted - Nature Profiling of the location and transcriptome of tissue-resident memory CD8 T cell formation at single-transcript resolution finds regionalized signalling as the basis of immune diversity in t...

Today in @nature.com. We mapped the spatial and temporal dynamics of intestinal tissue-resident memory CD8 T (TRM) cell differentiation.
🔗 www.nature.com/articles/s41....
@ucsandiego.bsky.social @lji.org @alleninstitute.bsky.social @amonell.bsky.social @reinacampos.bsky.social @GoldrathLab 🧵 1/10

Building Cure at the Seattle Children's Research Institute

Super excited to announce that the Joag Lab will officially open at @UW, @SCRI in March 2025! We will study the interplay between memory T cells and stromal, humoral, and innate immunity in mucosal tissues. researcherprofiles.seattlechildrens.org/Vineet.Joag. Hiring a technician and a postdoc!

CD4+ T cells reactive to a hybrid peptide from insulin-chromogranin A adopt a distinct effector fate and are pathogenic in autoimmune diabetes - PubMed T cell-mediated islet destruction is a hallmark of autoimmune diabetes. Here, we examined the dynamics and pathogenicity of CD4⁺ T cell responses to four different insulin-derived epitopes ...

great work from @ Jason Mitchell, @ Justin Spanier, and @ Brian Fife
pubmed.ncbi.nlm.nih.gov/39214091/

Cigarette smoke chemicals bind MR1 and modulate MAIT cell function in the lung through diverse mechanisms, impacting their ability to respond to respiratory infections and potentially contributing to disease
doi.org/10.1084/jem....

Nutrient-driven histone code determines exhausted CD8+ T cell fates ACLY-deficient CAR T cells targeting the tumor-associated antigen disialoganglioside GD2 (GD2 CAR T cells) also resisted acquiring TEX-like properties, exhibiting reduced CD39 expression when co-cultu...

The fate of T cells, such as seen in exhausted T cells, is tied to nutrients. This introduces the potential of therapies directed at keeping T cell identity and function intact. (And the infamous Krebs cycle makes a comeback to my brain)

www.science.org/doi/10.1126/...

Inflammation switches the chemoattractant requirements for naive lymphocyte entry into lymph nodes Lymph node swelling is a well-known symptom of infection. A shift in the chemoattractant code controls lymphocyte recruitment from blood into inflamed lymph nodes, allowing lymphocytes to accumulate so that even rare antigen-specific cells can encounter their activating antigen.

Elegant work by Jason Cyster's group

"Our study demonstrates that the canonical chemoattractant receptor-ligand systems well-established for lymphocyte homeostatic trafficking to LNs are no longer the major contributors in the inflamed setting." #ImmunoSky

Hi, can you please add me to this starter pack!? Thanks!

Hi Will, I'd like to join this starter pack! thanks!

Longitudinal Intravascular Antibody Labeling Identified Regulatory T Cell Recruitment as a Therapeutic Target in a Mouse Model of Lung Cancer Key Points. IV anti-CD45.2 label lasts for 3 days and tracks leukocyte migration to tissue.There is continuous innate and adaptive leukocyte migration in a

39 rotations around the sun! And what a year it's been. The lab has doubled in size. We had our first (3!!!) graduate students and post docs join the lab. We had both our first and second lab papers EVER accepted - the first is out in print... so check it out -(journals.aai.org/jimmunol/art...).

Would you prefer to lead a lab alone or together with a science buddy? How interesting would be a research institute where joint labs are the standard?!

Age-related decline in CD8+ tissue resident memory T cells compromises antitumor immunity - Nature Aging Exploring how aging compromises antitumor immunity, the authors reveal an age-related impairment of cytotoxic CD8+ TRM cells in mouse tumor models and clinical samples. They implicate BFAR signaling a...

Age-related decline in CD8+ tissue resident memory T cells compromises antitumor immunity
www.nature.com/articles/s43...

TCR signaling via NFATc1 constrains IL-15-induced NK-like activation of human memory CD8+ T cells
doi.org/10.1101/2025...

Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55

A commensal bacterium triggers systemic antibody responses via skin lymphoid structures and can be engineered as a topical vaccine – great therapeutic potential!

Two studies in @nature.com.web.brid.gy by the Fischbach and Belkaid labs

tinyurl.com/5yahn47t
tinyurl.com/4n4btxap

Scientists turned a harmless skin bacterium into a powerful vaccine delivery tool, boosting immunity in the lungs and nose.

@mfgrp.bsky.social @djenetbousbaine.bsky.social @nature.com

t.co/xXXCJx5VYm
#ImmunoSky 🧪

Inflammation switches the chemoattractant requirements for naive lymphocyte entry into lymph nodes Lymph node swelling is a well-known symptom of infection. A shift in the chemoattractant code controls lymphocyte recruitment from blood into inflamed lymph nodes, allowing lymphocytes to accumulate so that even rare antigen-specific cells can encounter their activating antigen.

Looks like I’ll need to update my lymph node lectures. Very nice explanation for why there is preferential leukocyte recruitment to inflamed nodes. #immunosky

How are durable antibody-responses to vaccines induced? News & Views paper discussing excellent new work by Cortese et al in Nature Immunology: www.nature.com/articles/s41...
Megakaryocytes promote long-lived plasmablasts via direct and indirect interactions. #ImmSky #HumanImmunology