Congrats Hauke. Very happy for you and your team!

Flexible ensheathment of axons enables myelination of complex CNS networks - Nature The rate of axon ensheathment varies within individual myelinating processes, resulting in chains of myelin sheaths connected by bridges consisting of thin cytoplasmic processes that provide&nbsp...

Latest offering. How myelin ensheathes axons!

Born from chat with Dwight Bergles on "weird things" we saw oligodendrocytes do, like making "bridges" between sheaths.

Driven forward by Cody Call, Kelly Monk, and myelin folks @edinburgh-uni.bsky.social

Enjoy!
www.nature.com/articles/s41...

Congrats Wendy. Super happy for you and to have another myelin lab in the north-east region!!

Myelin sheaths in the central nervous system can withstand damage and dynamically remodel Myelin damage is a hallmark of several neurological disorders, but how it occurs remains to be fully understood. In this study, we found that early damage in zebrafish and rodent demyelination models ...

Latest from the lab, led by @ara-donia.bsky.social and @juliavdkorput.bsky.social

Huge team effort, with immense contributions by friends from nearby and around the globe.

www.science.org/doi/10.1126/...

CDC42‐Effector Proteins Regulate Higher Order Structure of Septins Required for CNS Myelin Integrity CDC42-effector proteins 1/2 are present in CNS myelin. They facilitate the higher order structure of myelin septin filaments. Their loss impairs septin-dependent scaffolding of myelin. Myelin o...

If you're interested in the factors that enable the regular structure of CNS #myelin sheaths by #oligodendrocytes, check this out. Featuring a #CDC42 - effector proteins - #septin axis. Congrats to 1st author Sophie, and a big thank you to all who contributed

onlinelibrary.wiley.com/doi/10.1002/...

📢We are recruiting postdocs at the Albany Medical College to work on Schwann cells and the peripheral nervous system.

👉Apply here: albanymed.wd5.myworkdayjobs.com/en-US/Albany...

Or contact us directly ;)

Myelin is repaired by constitutive differentiation of oligodendrocyte progenitors Oligodendrocytes form myelin sheaths around axons to enable rapid signaling within neural circuits. The generation of new oligodendrocytes through differentiation of oligodendrocyte precursor cells (O...

alert! fundamental myelin biology - led by the amazing Yevgeniya Mironova and Dwight Bergles www.science.org/doi/10.1126/...

Congrats!

King's cake day in the Myelin Lab!

Oligodendrocyte mechanotransduction channel TMEM63A regulates myelin sheath geometry Dereddi, Djannatian, and colleagues show that oligodendrocytes use mechanical cues to measure axon size. The stretch-activated channel TMEM63A converts membrane tension into calcium signals, which cal...

We identified how mechanical forces shape myelin development. The TMEM63A channel in oligodendrocytes converts physical cues into molecular signals that control myelin growth.

Oligodendrocyte mechanotransduction channel TMEM63A regulates myelin sheath geometry: Neuron www.cell.com/neuron/fullt...

Post Doc Fellow in the Myelin lab - job offer LinkedIn share.google/BP44iJOBeJhb...

Mark your calendars! GLIA 2027 Call for Symposia opens 20 Jan–8 Apr 2026. All career stages & countries welcome. Accepted speakers get registration waived. More info: https://www.glia-meeting.eu/2027/call-for-symposia/
#Glia #Astrocytes #Microglia #Oligodendrocytes #NG2 #SchwannCells #StemCells

Pleased to share that I’ve been awarded a Catalyst Award from the @mssocietyuk.bsky.social 🥳
Many thanks to the MS Society UK for supporting our research in the @almeidalab.bsky.social and helping to advance understanding of MS!

Congratulations Sophie!!!!

Congrats! This is huge!

A flyer displaying the same information as written in the post, with two images of two astrocytes around a blood vessel and one newly formed oligodendrocyte, along with logs our sponsors Avantor and Plasmidsaurus.

If you are attending #SfN25, please join @amygleichman.bsky.social and I on Monday at 9PM for a casual social gathering to discuss all things non-neuronal!

Date: Monday, Nov 17th
Time: 9PM till close
Location: The Smoking Gun SD, 555 Market St.

All welcome, please free to spread the word!

Myelin injury precedes axonal injury and symptomatic onset in multiple sclerosis - Nature Medicine Myelin damage in multiple sclerosis can be detected up to 7 years before symptoms, with early immune pathway activation and a 21-protein panel showing promise for presymptomatic diagnosis.

www.nature.com/articles/s41...

Economics Nobel prize won by researchers who showed how science boosts growth Joel Mokyr, Philippe Aghion and Pewter Howitt share economics prize for work that underlines the importance of investing in research and development.

Joel Mokyr, Philippe Aghion and Pewter Howitt share economics prize for work that underlines the importance of investing in research and development.

go.nature.com/4hj9NNV

Targeting prostaglandin E2 receptor 2 in Schwann cells inhibits inflammatory pain but not inflammation - Nature Communications Non-steroidal anti-inflammatory drugs (NSAIDs) are known to alleviate pain by reducing inflammation. To the contrary, here, the authors show that selective inhibition of the prostaglandin E2 receptor (EP2) in Schwann cells eliminates pain without disrupting the protective and healing functions of inflammation.

NSAIDs are known to alleviate pain by reducing inflammation. A study in Nature Communications shows that selective inhibition of the prostaglandin E2 receptor in Schwann cells eliminates pain without disrupting the protective and healing functions of inflammation. #medsky 🧪

Spatial lipidomics reveals demyelination and remyelination dynamics in the mouse brain Myelin pathology in demyelinating diseases is accompanied by lipid remodeling that remains challenging to characterize at spatial level using traditio…

Remyelinated fibers have a distinct lipid profile compared to intact myelin
www.sciencedirect.com/science/arti...

Deletion of murine Sarm1 results in a microenvironment that delays peripheral nerve regeneration after injury In Sarm1-deficient mice, peripheral nervous system regeneration is delayed after injury.

Paper Alert!! Our collaborative work with Giger Lab at UMich is out now in #ScienceTranslationMedicine Deletion of murine Sarm1 results in a microenvironment that delays peripheral nerve regeneration after injury | Science Translational Medicine @science.org
www.science.org/doi/10.1126/...

Medicine Nobel goes to scientists who revealed secrets of immune system ‘regulation’ Mary Brunkow, Fred Ramsdell and Shimon Sakaguchi discovered cells that protect the body from autoimmune diseases.

This year’s Nobel Prize in Physiology or Medicine has been awarded to three scientists for discovering a class of immune cells that help to prevent the body from attacking its own tissues

go.nature.com/48QDdAJ

Post-Synaptic Density Proteins in Oligodendrocytes are Required for Activity-Dependent Myelin Sheath Growth Neuronal activity regulates myelination in the central nervous system, highlighting the critical importance of axon-oligodendrocyte communications in …

"Post-Synaptic Density Proteins in Oligodendrocytes are Required for Activity-Dependent Myelin Sheath Growth"
www.sciencedirect.com/science/arti...

Gtf2i-encoded transcription factor Tfii-i regulates myelination via Sox10 and Mbp regulatory elements - Nature Communications The transcriptional regulation of oligodendrocytes has an essential role in myelin formation and maintenance. Here, the authors identify the transcription factor Tfii-i as a regulator of myelin genes expression in the nervous system and show that its loss enhances myelin thickness and nerve conduction.

🚀 Our new paper is out in Nature Communications!

We uncovered a mechanistic switch to boost myelination: deleting Gtf2i in myelinating glia enhances Sox10/Mbp activity → thicker myelin, faster conduction, improved motor coordination.

Open access link:

www.nature.com/articles/s41...

What Happens When Scientists Flip the Switch on PMP22? | Charcot–Marie–Tooth Association What happens when scientists flip a hidden switch inside nerve cells? A CMTA-funded $281,339 study is testing whether this discovery could finally bring new ...

cmtausa.org/simply-cmt/c...

Metformin alters mitochondria-related metabolism and enhances human oligodendrocyte function Nature Communications - Metformin is under clinical trial for brain neuroprotection but how it may work is poorly understood. Here, the authors show that metformin helps myelin formation by human...

Our new paper on metformin, myelin, mitochondria and metabolism is now out at rdcu.be/eDbFD
Thanks to Nina and all of the team!

Transient gene melting governs the timing of oligodendrocyte maturation Oligodendrocyte maturation is governed by an SOX6-dependent gene-melted chromatin state at multiple immaturity loci. Reducing SOX6 accelerates maturation, offering a potential strategy to regenerate myelin in diseases like multiple sclerosis.

Now online! Transient gene melting governs the timing of oligodendrocyte maturation

Emerging connections between myelin and Alzheimer’s disease - Nature Cell Biology Recent literature has explored the contributions of oligodendrocytes and myelin dysfunction to Alzheimer’s disease. Here, we discuss emerging evidence that oligodendrocytes may directly contribute to ...

Emerging connections between myelin and Alzheimer’s disease

www.nature.com/articles/s41...

www.nature.com/articles/s41...

PNS Training Grant Program - Mobility Requirement Waived for All Applicants & Other Exciting Updates - pnsociety.com

Very excited by the updates to the PNS fellowship!

pnsociety.com/pns-training...