Distinct #Cdc42 protein levels differentially regulate polarized growth and cell fusion in Schizosaccharomyces pombe

The work of @sajjitasaha.bsky.social and @aiswaryasajeevan.bsky.social, with Laura Merlini and Vincent Vincenzetti, now out in @plosbiology.org !

@biology-unige.bsky.social

Oligomerization-dependent and synergistic regulation of Cdc42 GTPase cycling by a GEF and a GAP - EMBO Reports Cell polarity is a crucial biological process essential for cell division, directed growth, and motility. In Saccharomyces cerevisiae, polarity establishment centers around the small Rho-type GTPase C...

New paper out in EMBO Reports!
We show that Cdc42 regulation is oligomerization-dependent and that a GEF and a GAP act synergistically: Cdc24 relieves self-inhibition of oligomeric Rga2, enabling robust Cdc42 cycling.
doi.org/10.1038/s44319-026-00695-7
#cellpolarity #Cdc42 #synergy #syntheticbiology

CDC42‐Effector Proteins Regulate Higher Order Structure of Septins Required for CNS Myelin Integrity CDC42-effector proteins 1/2 are present in CNS myelin. They facilitate the higher order structure of myelin septin filaments. Their loss impairs septin-dependent scaffolding of myelin. Myelin o...

If you're interested in the factors that enable the regular structure of CNS #myelin sheaths by #oligodendrocytes, check this out. Featuring a #CDC42 - effector proteins - #septin axis. Congrats to 1st author Sophie, and a big thank you to all who contributed

onlinelibrary.wiley.com/doi/10.1002/...

BOO‑associated #BladderFibrosis is driven by #EMT‑linked cytoskeletal remodeling via the TGF‑β/Cdc42/Cdc42ep1/F‑actin/Fibronectin axis; #Cdc42 inhibition suppresses #fibrosis, highlighting cytoskeletal regulators as therapeutic targets.

#OpenAccess: doi.org/10.1016/j.ge...

Dr Honorine Ward highlights Adam Sateriale & colleagues’ @cp-cellhostmicrobe.bsky.social article on a #virulence factor, #Cryptosporidium #MVP1, modulating #intestinal #microvilli by interacting with host #EBP50 & #CDC42. @tuftsmedicalcenter.bsky.social

authors.elsevier.com/a/1lH505Eb1x...

Cdc42 deletion yielded enamel defects by disrupting mitochondria and producing reactive oxygen species in dental epithelium

This study demonstrates the multidimensional and pivotal role that #Cdc42 plays in #enamel development and #ToothRepair, using inducible epithelium-specific knockout Cdc42 mice, and underscores its part in #Ameloblast differentiation and enamel matrix formation. #medsky

#OpenAccess: buff.ly/lJePLwg