10x Genomics introduces Atera, a new platform to redefine how biology is measured and understood.

Atera removes the trade-offs that have constrained research, unlocking a new era of insight that will transform our understanding of science and human health.

Atera delivers whole-transcriptome spatial data with single-cell sensitivity at scale.

Studying biology has long meant working with fragmented tools. With Atera, for the first time ever, biology can be measured as a complete system in its native context, at scale, removing the constraints that have held spatial biology back: https://bit.ly/48bYvYF

1/ Philipp Mallm from the @dkfz.bsky.social Single-cell Open Lab just broke the news at #AACR26: the first results on colorectal cancer (CRC) tissue analysis with the new Atera spatial transcriptomics platform from @10xgenomics.bsky.social. Is it "making the impossible possible?" 🧵

Uncompromised Spatial: Only on Atera

Last night we unveiled the impossible. Now we invite you to check out Atera for yourself at booth #3217! Or, if you're not at #AACR26, register for one of our webinars starting 4/21 to get a deeper look into the future of #spatialbiology: https://bit.ly/4b5SnBx

While there is a lot of momentum in spatial transcriptomics, Atera brings true acceleration. Excited to see how Atera will increase our understanding of biology and help improve human health. Let me know if you want to talk.

Capturing somatic mutations in single-cell probe-based assays (ie. 10X Flex) is a hard task, especially if you don't know *exactly* the mutations you want to capture, or if your target sequence is a mutational hotspot with many possible alternative alleles. Here's the way we pulled this off. Enjoy!

10x Genomics World Tour 2026 | Leuven

Join us in Leuven to see the (im)possible with your own eyes! Register here, limited seats available: pages.10xgenomics.com/ugm-2026-04-...

The impossible arrives in just two short weeks: where will you be when it does?

oin us for our webinar on 4.21 and witness the start of impossible breakthroughs: https://bit.ly/4sm2KrX

#10xGenomics

10x Genomics World Tour 2026 | Leuven

Join us in Leuven to see the (im)possible with your own eyes! Register here, limited seats available: pages.10xgenomics.com/ugm-2026-04-...

Spatial Gut-Microbiome MegaTranscriptomics

Use in situ polyadenylation on #Visium #StereoSeq to enhance host & bacterial RNA recovery (⏫99-fold)

Fresh-frozen🐭GI

Non-coding RNAs enriched to gut wall

Microorganisms enriched at CRC tumor boundary

#NatMicrobiol 2026
www.nature.com/articles/s41...

Exciting news! Our Epi Multiome assay is getting the GEM-X performance upgrade with incredible benefits across the entire workflow, from more reliable sample prep to higher gene sensitivity and more. Pre-order today > https://bit.ly/4sZwefD

Every sample has a story. And it could change someone's life.

Uncover the biology behind treatment success or failure by profiling FFPE and fixed whole blood samples. Learn how single cell and spatial are revolutionizing biomarker research in cancer, immunology, and neuroscience.
bit.ly/40RqhFr

Welcome to the first edition of #SampleSpotlight! Every week, we’ll highlight a different sample type that works seamlessly with the Flex Apex assay. This week’s spotlight: FFPE tissue. Every sample has a story. Tell them with Flex Apex. Find out more: https://10xgen.com/1WD

From #PCR, to #NGS, to #scRNAseq, yesterday’s pipe dream is today’s standard. Science follows a pattern, after all: first, something’s impossible. Then, it’s indispensable. So what’s next on that list?

Join us for a webinar this April to find out. https://bit.ly/4tJv9tD

Science, at its core, is about breakthroughs: discovering new methods, finding new answers, and figuring out that the impossible...isn’t. So what will you do when you can achieve the impossible? https://bit.ly/4rZJ5Ot

What if you could simply ask your analysis tools for answers? We’re collaborating with Anthropic to make that happen, working to turn #singlecell & #spatial analysis into a natural conversation, not a coding lesson. Learn more > https://bit.ly/4nkyURZ

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Concluding remarks by the authors part 2: "The Flex workflow proved to be amenable to sample collection at the clinical site, making it the best choice for implementation in clinical trials."

Concluding remarks by the authors: "We determined that Flex exhibited the best performance, with the proportions of neutrophils captured in blood samples comparable to those observed by flow cytometry."

Comparison of single-cell RNA-seq methods to enable transcriptome profiling of neutrophils in clinical samples Hatje et al. evaluate current fixed single-cell technologies to determine their suitability for measuring the neutrophil transcriptome and their potential for implementation in clinical trials.

Another independent benchmarking study, this time on neutrophils. Comparing 10X 3 prime, 10X Flex, Parse Evercode and Hive.
www.cell.com/cell-reports...

ikea-style logo of splongget

1/ First preprint from @jdemeul.bsky.social lab 🥳! We present our new multi-modal single-cell long-read method SPLONGGET (Single-cell Profiling of LONG-read Genome, Epigenome, and Transcriptome)! www.biorxiv.org/content/10.1...

Imagine detecting bone marrow disorders without a painful aspiration! The PERIBLOOD clinical trial by CLISEQ Ltd., the Weizmann Institute of Science & Weizmann’s commercial arm Yeda will see if a blood draw & GEM-X #scRNAseq could help develop future diagnostics. https://bit.ly/46i7TrX

✨ Join us on August 28 for an educational webinar that covers the #Xenium workflow, including new features of the platform and expert tips and tricks 🔬 Learn more and reserve your spot here: bit.ly/3U2D5FT

Plant-Compatible Xenium In Situ Sequencing: Optimised Protocol for Spatial Transcriptomics in Medicago truncatula Roots and Nodules Elucidating the spatial and temporal regulation of gene expression during plant organogenesis is crucial for enabling precise crop improvement strategies that incorporate beneficial traits into crops ...

Yes, you can use @10xgenomics.bsky.social Xenium high resolution transcriptomics on plants. Jhu et al. wrote a "how-to-guide" with specific protocol modifications. Medicago truncatula roots and nodules FFPE tissue, 480 genes. Check it out here: www.biorxiv.org/content/10.1...

What a cool paper!

This is SO COOL!

One Section, Two Worlds: Single-Cell Integration of MALDI-MSI and Spatial Transcriptomics on the Same Single Tissue Section Understanding tissue complexity requires spatially resolved multiomic data at single-cell resolution. Here, we present a workflow that integrates high-resolution matrix-assisted laser desorption ioniz...

New preprint by M4I, Maastricht, The Netherlands integrating high-resolution MALDI-MSI with Xenium single cell spatial transcriptomics on one single tissue section. www.biorxiv.org/content/10.1...

10x Genomics

Want to learn more about high resolution, high plex spatial transcriptomics? New 10X Genomics Xenium educational webinar on Thursday Aug 28, 2025 ⋅ 15:00 – 16:00 (Central European Time - Brussels).
Register here: bit.ly/4fjtYKM

New on Xenium: validated & ready-to-use protein panels! Now you can analyze 27 proteins alongside #spatial RNA for multiomic insights into #cancer, #immunology & more. Get a hands-on look with our interactive dataset & then pre-order your assay: bit.ly/4o0896R

Highly recommended read if you are looking into spatial transcriptomic options.