BAP1 dysregulation impairs trophoblast differentiation and contributes to placental dysfunction in preeclampsia Preeclampsia, a life-threatening hypertensive disorder of pregnancy, is a leading cause of maternal and perinatal morbidity and mortality. Its early-onset form (EO-PE), requiring delivery before 34 we...

🚨Preprint! #Placental #organoids developing #preeclampsia (PE)?🤯Boosting #BAP1 induced key traits of early-onset PE:
❌impaired syncytialization & EVT differentiation
🔥persistent pro-inflammatory signals
🤒broad placental dysfunction
🚀🥦🎉team!
@cbm-csic-uam.bsky.social
www.biorxiv.org/content/10.1...

Sex and smoking bias in the selection of somatic mutations in human bladder - Nature Sex bias and association with smoking history identified in the landscape of driver mutations and clonal expansions in normal human bladder tissue may explain the higher bladder cancer risk in men and smokers.

🚨 New paper alert!

Sex and smoking bias in the selection of somatic mutations in human bladder

www.nature.com/articles/s41...

by @raquelbmi.bsky.social, @ferriol.bsky.social et al (in collaboration with Rosana Risques lab in @uwmedicine.bsky.social)

New preprint! 🚨 We uncover a slow adaptation to stretch that links star-bundling of keratin filaments with nuclear escape from its keratin cage. Led by @tomgolde.bsky.social‬ 🙌
@IBECBarcelona
www.biorxiv.org/content/10.1...

We are looking for a postdoc for an ERC funded project at @albertpol.bsky.social Lab at @idibaps.bsky.social in Barcelona. Do you want to use 3D #epithelioids to study the role of lipid droplets against bacterial infections? Come and join us!👇
www.clinicbarcelona.org/uploads/medi...

Un estudi revela com les mutacions pro-tumorals a l'esòfag s'expandeixen durant l'envelliment

https://s.mtrbio.com/gispeedbnb @albertpol.bsky.social @albertherms.bsky.social

We are looking for a postdoc for an ERC funded project at @albertpol.bsky.social Lab at @idibaps.bsky.social in Barcelona. Do you want to use 3D #epithelioids to study the role of lipid droplets against bacterial infections? Come and join us!👇
www.clinicbarcelona.org/uploads/medi...

'iFlpMosaics enable the multispectral barcoding and high-throughput comparative analysis of mutant and wild-type cells'
www.nature.com/articles/s41...

Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55

#IDIBAPS IN-HOUSE Seminar

Understanding how mutant cells colonize normal epithelia

📆12/12
🕰️15:00
👨‍🔬Albert Herms
📍 Esteve Auditorium, Centre Esther Koplowitz
💻 Hybrid event: https://bit.ly/3BecnUR

👉 https://bit.ly/3ZEfOgW

Thanks!

Could you add me, please?

🆕A 3D culture system makes it possible to simulate the behavior of epithelial tissue

This technique is an key step forward in understanding how mutations expand in tissues as we age
@albertherms.bsky.social @albertpol.bsky.social @hospitalclinic.bsky.social

www.clinicbarcelona.org/en/news/a-ne...

'High-density sampling reveals volume growth in human tumours'
elifesciences.org/reviewed-pre...

We recently announced a dual new release of intOGen and boostDM

Computational analysis of 33,218 tumor genomes to identify cancer genes and driver mutations

➡️ Compendium of Cancer Driver Genes - www.intogen.org

➡️ In Silico Saturation Mutagenesis of Cancer Genes - www.intogen.org/boostdm

Obesity-dependent selection of driver mutations in cancer - Nature Genetics Analysis of pan-cancer clinical genomic sequencing finds that body mass index associates with driver mutations in certain cancer types, including most prominently lung adenocarcinoma. Obesity may thus...

Obesity-dependent selection of driver mutations in cancer - Nature Genetics 🧪
www.nature.com/articles/s41...

Congrats to Ed Reznik & colleagues

Thank you!

Hi! Nice topic! Could I be included, please? I work in epithelial primary 3D cultures studying mutant cell competition: www.nature.com/articles/s41...

Somatic mutation and selection at epidemiological scale As we age, many tissues become colonised by microscopic clones carrying somatic driver mutations ([1][1]–[10][2]. Some of these clones represent a first step towards cancer whereas others may contribu...

Resharing here a recent X post. In this preprint, we introduce an improved version of NanoSeq, a duplex sequencing protocol with <5 errors per billion bp in single DNA molecules, and use it to study the somatic mutation landscape of oral epithelium in >1000 people. 1/ www.medrxiv.org/content/10.1...

Improving cancer genome interpretation for precision medicine in oncology - CGI-Clinics

CGI-Clinics project just joined Bluesky.

Follow it to stay tuned on exciting updates coming soon about the project

👉 @cgiclinics.bsky.social

cgiclinics.eu

Our group investigates the role of #lipid droplets (green) in killing intracellular pathogens (blue, E coli in human macrophages) when they are searching for nutrients. In our family we have nicknamed them defensive lipid droplets and FATal attraction. Credit @robparton.bsky.social @UQpress

Intercellular nanotube-mediated mitochondrial transfer enhances T cell metabolic fitness and antitumor efficacy Transfer of mitochondria via nanotubes from bone marrow stem cells to CD8+ T cells augments cellular metabolism, empowering engineered T cells and tumor-infiltrating lymphocytes to counteract exhausti...

Intercellular nanotube-mediated mitochondrial transfer enhances T cell metabolic fitness and antitumor efficacy 🧪
www.cell.com/cell/fulltex...