Resolution of epithelial dysfunction in eosinophilic esophagitis is mediated by an HIF-1α-CD73-adenosine signaling axis Inflammatory hypoxia is induced by eosinophilic inflammation, while a decreased expression in the key hypoxic regulator, hypoxia-inducible transcripti…

Huge congratulations to rock 💫 Shauna Kellett from my lab publishing her @ResearchIreland funded MSc(Res) 🎉

showing that #HIF-1α-CD73-adenosine signaling axis is important in the resolution of #EoE associated #epithelial dysfunction

www.sciencedirect.com/science/arti...

It’s a privilege & thrill to watch rockstar 💫 @maynoothuniversity.ie PhD student @shaunakellett.bsky.social present her @researchireland.ie funded
MScRes to International Eosinophil Society on CD73/ADO in epithelial dysfunction in Eosinophilic Esophagitis #EoE
Fantastic #ECRs conference 🎉
#ProudPI

For World Eosinophilic Esophagitis Day, we’ve curated a list of recent #EoE articles from across the journal portfolio:
🟣 ow.ly/Qjlo50VXmVx
🟣 ow.ly/UrEV50VXmVy
🟣 ow.ly/rkVL50VXmVw
🟣 ow.ly/JibY50VXmVz
🟣 ow.ly/Fr9950VXmVA

#EoEDay
@amergastroassn.bsky.social

#ProudPI #VivaDone

…and from out of the box emerged the most brilliant scientist you’d ever seen, Dr Louise Crowe

Beyond thrilled. Very many congratulations Louise. 🎉

Many thanks to Dania Movia and Desmond Tobin for a robust viva

Another 💫 from the #AIRRLab Maynooth University & MULonsdale

Congrats Olga Fagan Superstar MD student 💫

Important update on the #RareDisease that is very much a growing problem in Irish adults, Eosinophilic Esophagitis #EoE #allergy

Gratitude to collaboration between @MaynoothUni & @stjamesdublin & to @hrbireland for supporting this.

Sociodemographic biases in medical decision making by large language models - Nature Medicine A panel of nine LLMs was exposed to simulated clinical cases with switched sociodemographic features exploring ethnic, social, sexual orientation and gender dimensions and showed differences in recommendations for patient treatment, referral and follow-up based only on these features.

A study in Nature Medicine exposed LLMs to simulated clinical cases with switched sociodemographic features exploring ethnic, social, sexual orientation and gender dimensions and showed differences in recommendations for patient treatment, referral and follow-up based only on these features. 🔒

It was great to be invited by Research Ireland as a panelist for these thought provoking events & to hear such encouragement from minister James Lawless regarding the appetite for collaboration and engagement regarding the future of research & its continued importance in Ireland.

This days purpose is to achieve full & equal access & participation of girls & #WISTEM.
I will continue to do my utmost to promote this. In ever challenging times, I especially celebrate those women who lifted me up, pushed me onwards and who continue to my support.
Let’s continue to #PayItForward

This is a fantastic opportunity to advance your career with a powerhouse of women in GI Sciences! Sign up today!!

Count down: The 5 top accessed research manuscripts of 2024!

#4: AARS1 senses lactate and acts as a lactyl-transferase to promote YAP signaling in gastric cancer

https://www.jci.org/articles/view/174587

After we reach advanced age, around 80, the propensity to develop cancer is markedly reduced. A discovery reported at Nature today about aged stem cells and iron insufficiency may help explain this advantage

www.nature.com/articles/d41...

Great starter pack for #stemcell biologists. 😊🩵🦋

go.bsky.app/UTW4d7b

Women are under-represented at senior levels in #academia globally, & across all #science 🧪 disciplines, as shown by these "scissor-shaped curves" ✂️

So how can we ever achieve #gender #equality?

We discuss various strategies in this #Cell Commentary

#WomeninSTEM

www.cell.com/cell/fulltex...
🧵 1/

!!!

Thanks very much K!

Thanks Dee! I’ve pretty awesome RDO colleagues backing it all up! 👍

Delighted to have been recognised in this '25 scientists you need to know about' piece. Honored to be amongst such amazing Irish Scientists 💫
@maynoothuni.bsky.social
#IrishResearch

The science version of “what doesn’t kill me makes me stronger”: Scientists with ‘near misses’ early in their careers outperform those with ‘narrow wins’ in the longer run.
www.nature.com/articles/s41...

Hi Jens, Happy to join. Esophageal & Gut organoids here.

LTβR deficiency causes lymph node aplasia and impaired B cell differentiation Loss-of-function mutations in LTBR result in a stromal defect, leading to dysfunctional secondary lymphoid organs and combined immunodeficiency in humans.

New in #ScienceImmunology:

Research from @boztugk.bsky.social and team identifies an inborn error of #immunity caused by human LTβR deficiency, resulting in defective stromal cell signaling and impaired humoral immune responses.

Read more: www.science.org/doi/10.1126/...

One of our latest @ JACI
Important role for #HIF driven #metabolic dysfunction in #epithelial differentiation defects in #EoE

Thanks to collaborators @maynoothuni.bsky.social @ StJamesDublin @ChildrensColo @cuanschutz.bsky.social 💶 @researchireland.bsky.social

www.jacionline.org/article/S009...