Portrait of Joseph G. Gall in a library setting with a microscope, highlighting his early interest in microscopic organisms.
🧪Lasker Laureate & Carnegie Science biologist Joseph G. Gall was born #OTD.
Gall won a 2006 Lasker Award for a distinguished 57-year career as a founder of modern cell biology & the field of chromosome structure & function. He was also an early champion of women in STEM: http://ow.ly/C8pR30oehxS
Check out Schnell's profile to learn more about her cutting-edge research: www.jccfund.org/fellows/#mod...
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By better understanding their origin stories and how that impacts function, Schnell hopes to shed light on how to knock out the villainous tumor promoting TAMs.
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Just like superheroes and villains, Dr. Schnell thinks that TAMs’ origin stories may be the key to their different functions. Schnell is developing a tool to track the development (origin story) of TAMs, their presence in tumors, and how they respond to immunotherapies.
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... which are the most abundant type of innate immune cells found in tumors. TAMs can either prevent or assist tumor progression, and it’s unclear why they can have such dichotomous behavior.
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It is increasingly appreciated that the tumor microenvironment – mini ecosystems made up of both cancer and healthy cells – plays an important role in how cancers respond to treatment.
Jane Coffin Childs Featured Fellow Dr. Alexandra Schnell is investigating tumor-associated macrophages (TAMs)
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By mapping where these macrophages are and how they interact with the brain, she can identify new targets to improve the outcome of inflammatory diseases.
#immunology #singlecell #spatialbiology #research #macrophages
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Their position here suggests that the immune system is moving into the tissue.
This matters for diseases like multiple sclerosis, a disease where a person’s immune system mistakenly attacks the protective coating around nerve fibers in the brain and spinal cord.
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Using a tool called PEtracer, Alex can track which cell came from whom over time while still seeing where each cell sits in the tissue.
The purple dots around the outside of this brain slice are macrophages, immune cells that rush into tissues when something’s not right.
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Jane Coffin Childs Fellow Dr. Alexandra Schnell tracks immune cells in brain tissue to understand how they affect disease.
Imagine the brain slice presented here as a busy neighborhood, with every dot in this picture a different “resident” or cell.
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Several staff scientist positions available in our lab at Stanford University!
More details and application at the link below
@a-p-s-a.bsky.social
@a-p-s-a.bsky.social
In this "Everyday Scientists" video, Rohini shares how adopting a keto diet can help cancer patients alleviate weight loss symptoms—and fight the tumors that derive their energy from carbohydrates.
🧪#CancerControlMonth Jane Coffin Childs Fund for Medical Research
Study Reveals Octopus Mating Arm Doubles as a Chemical Sensor 🧠 🧪🧬 #AcademicSky #higherEd #sciencecommunication #research
www.mcb.harvard.edu/department/n...
@nbellono.bsky.social @harvardbrainsci.bsky.social @hsph.harvard.edu @harvardmed.bsky.social @oistedu.bsky.social @rachellegaudet.bsky.social
Pablo Villar et al discover male octopus mating arms are sensory organs used to find females, navigate internally to the oviduct & deliver sperm. From behavior to structure, these findings offer a framework for how sensory systems shape reproduction & species barriers
www.science.org/doi/10.1126/...
My final paper from grad school is out! Thank you to @marisosa.bsky.social @ellasay.bsky.social and my co-first author Konstantin Kaganovsky!
We show that reward and novelty coding in the hippocampus requires a specific membrane fusion protein implicated in activity-dependent AMPAR mobilization!
Congratulations to @bribrammer.bsky.social, an MSTP student at Emory University, for winning APSA's FIRST 3 Minute Thesis Competition! This competition brought together physician-scientist trainees from across the nation to present their research. Thank you to our volunteers and judges!
Next, she wants to investigate whether the use of different wound closure strategies changes how Hofstenia worms regenerate tissues.
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Her recent preprint investigates wound closure, the first step in successful regeneration.
Kann found that the type of wound closing strategy used depends on how the worm is injured.
www.biorxiv.org/content/10.1...
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Kann is particularly focused on the role of cell adhesion in regeneration; that is, how do neighboring cells disassemble, remodel, and grab onto new neighboring cells during wide-scale regeneration?
www.jccfund.org/fellows/#mod...
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As spring buds emerge from old tree limbs, Jane Coffin Childs Featured Fellow Dr. Allison Kann @apkann.bsky.social is interested in a different form of regeneration; Dr. Kann studies the worm Hofstenia miamia, which can regrow its entire body after major amputation.
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By studying how this tissue is rebuilt, Allison is working on identifying potential breakthroughs in human tissue and organ regeneration.
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Using Hofstenia miamia, Allison is specifically looking at the regeneration of the pharynx: a muscular tube that connects the mouth and the gut, allowing these animals to eat.
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(such as Hofstenia miamia, a small marine worm) that can perfectly rebuild any missing or injured piece of their body.
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Jane Coffin Childs Fellow Dr. Allison Kann @apkann.bsky.social is working at the forefront of regeneration research.
We as humans aren’t great at regenerating, or healing our tissues and organs after major injuries. However, there are many amazing creatures in nature ...
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How can the immune system inform recurrence risk?
In the latest "Everyday Scientists" video from the Jane Coffin Childs Fund for Medical Research, Bri shares how immune cell abundance may correlate with cancer recurrence. She hopes her discoveries could support more personalized care. ❤️🩹🧪
Fluorescent embryo showing the developing epidermis, pseudo-colored with the ICA LUT in FIJI
Our transgenic acoel embryos are beautifully mosaic 😍 showing off the developing epidermis for #FluorescenceFriday
Peripheral muscle fibers (pseudocolored in magenta) and nuclei (in gray)
Today's #FluorescenceFriday is featuring the peripheral muscle of Hofstenia miamia 💪
