Alergia al cacahuete: la ciencia mira a la boca para frenar la enfermedad La saliva, clave contra la alergia al cacahuete, según el hospital La Princesa de la Comunidad de Madrid y la Universidad de Canadá

La saliva, clave contra la alergia al cacahuete, según el hospital La Princesa y la Universidad de Canadá: okdiario.com/salud/saliva...

Una bacteria de la saliva 'protege' de la alergia al cacahuete, destruyendo en la boca las proteínas dañinas Dos personas alérgicas a un mismo alimento pueden tener reacciones de diferente intensidad. Lo que una tolera sin problemas, en otra desencadena una fuerte respuesta. Entre las...

Muy agradecidos a El Mundo por divulgar nuestro trabajo en
@cp-cellhostmicrobe.bsky.social donde demostramos que #bacterias orales degradan #alérgenos alimentarios, modulando respuestas #IgE y #anafilaxia.
www.elmundo.es/ciencia-y-sa...

Excessive #inflammation?
We uncover @cp-immunity.bsky.social that #IFN-I via #ISG15 in macrophages lowers #mitochondrial membrane potential, boosts #efferocytosis, and self limits #ISG amplification: a built in brake that promotes resolution. Open-access: www.cell.com/immunity/ful...
#immunosky

Thanks, Super-Gillian! Considering all the accumulated rainfall in Spain this winter, I bet this hay fever season will be quite intense in our country. I encourage people with allergies to consider getting vaccinated, the onlyway to modify the course of the disease, not just relieve the symptoms.

This work was only possible thanks to the collaboration of @jimenez-saiz-lab.bsky.social

Thanks Antonio!

6/6 In summary: fine-tuning cross-linking stoichiometry is key to designing allergen vaccines that are less reactive yet still immunogenic — a meaningful step toward safer therapies.

5/6 Using different glutaraldehyde-to-protein ratios to polymerize Phleum pratense and Betula verrucosa extracts, we observed that the larger and more densely cross-linked the polymers were, the lower their IgE reactivity and their ability to activate mast cells.

Frontiers | Impact of cross-linking stoichiometry on the structure and allergenicity of glutaraldehyde-polymerized allergen extracts IntroductionPolymerized allergen extracts are widely used in allergen immunotherapy (AIT) to reduce allergenicity and enhance safety. However, the impact of ...

4/6 A new study from our R&D department (Inmunotek) investigated how the proportion of glutaraldehyde used to polymerize grass and birch pollen extracts alters their structure and allergenicity. www.frontiersin.org/journals/imm...

3/6 Today, glutaraldehyde-polymerized allergen extracts are routinely used to treat allergic patients. However, it remains unclear how the proportion of reactants affects their structure and safety. Are all polymers the same?

2/6 The conceptual model stemmed from the detoxification of bacterial toxins with formaldehyde and the generation of toxoids nearly 100 years ago—where immunogenicity is preserved while toxicity is reduced. pasteur.fr/en/research-...

🧵 1/6 Vaccinating allergic patients carries risks: the patient’s IgE recognizes allergen extracts and can trigger severe adverse reactions. To address this, Dr. Roy Patterson (1970s) proposed an innovative approach: modifying the extracts by polymerizing them with glutaraldehyde.

Preprint: Type I IFN activates border-associated macrophages to drive MHC-I–dependent immune surveillance after stroke
www.researchsquare.com/article/rs-8...

@salva-iborra.bsky.social and Co in @jem.org elegantly sow that plasmacytoid DCs expand tissue-resident memory CD8+ T cell responses during viral reinfection

rupress.org/jem/article/...

My main PhD paper is finally out! 🎉

After ~5 years, it’s published today in 𝘕𝘢𝘵𝘶𝘳𝘦 𝘐𝘮𝘮𝘶𝘯𝘰𝘭𝘰𝘨𝘺.
@natimmunol.nature.com

It all started with an unexpected observation 🔍:
👉 Mice lacking the dendritic cell receptor DNGR-1 developed tumours earlier ⏩ and more frequently 📈 than wild-type mice.

1/11 🧵

On the use of murine models: Results should be interpreted with caution. Batf3-deficient mice have been traditionally used as a model to study the function of cDC1; however, this transcription factor seems to play other essential roles in other immune populations👇

BATF3 controls the homeostatic maintenance and function of innate-like γδ T cells γδ T cells compose an evolutionarily conserved lineage of lymphocytes, with both adaptive- and innate-like characteristics, contributing to tissue homeostasis, immune surveillance, and rapid responses...

Isn't this the coolest Christmas present (or miracle) for a #gdTcell aficionado?! Our latest preprint showing the role of BATF3 on gd T cells is ou on bioRxiv:
www.biorxiv.org/content/10.6...

Qian Zhang et al. @casanovalab.bsky.social @rockefeller.edu report a fatal case of avian #influenza #H5N1 infection caused by autoantibodies neutralizing type I IFNs. These rogue autoantibodies are common, especially in elderly people. rupress.org/jem/article/...
(1/2) 🧵 👇

Feel better during the day than at night during #influenza? Find out the “Role of IL-10 signaling in the #circadian control of host response to influenza infection” www.mucosalimmunology.org/article/S193...

mRNA vaccines 💉don't cause death but prevent it

Massive study from France showed that mRNA vaccines reduced deaths and saved lives @mahmoudzureik.bsky.social @jama.com

jamanetwork.com/journals/jam...

Fascinating study revealing how NK cells can eliminate intracellular E. coli infecting the urothelium.
-Just a comment on the NK depletion experiment, NK1.1 is also expressed by ILC1s, NKT and most γδ T1 cells (IFN-γ producers).

👇No os lo perdáis! Hoy, a las 19:00 h, Oscar Palomares hablará en Allergotrends (Inmunotek) sobre los"Avances en inmunidad innata entrenada en inmunoterapia específica de alérgeno: Vacunas bacterianas para la prevención y tratamiento del asma alérgica". eventos.quodem.com/allergotrend...

¿Por qué es más difícil reinfectarnos de un virus que ya hemos tenido? Científicos españoles descubren cómo refuerza el sistema inmunitario la defensa del organismo frente a patógenos como la gripe

Gracias @larazonlr.bsky.social ! Por hacerse eco de nuestra investigación.
www.larazon.es/salud/que-ma...

Guidelines for T cell nomenclature - Nature Reviews Immunology This Consensus Statement clarifies the existing subset-based nomenclature for T cells. Furthermore, it proposes an alternative modular nomenclature that is designed to be brief and flexible and to avo...

..cross your 't's folks.. here's how!

www.nature.com/articles/s41...

Delighted to have written this Insight article together with @victor-bosteels.bsky.social and Will Stainier about a cool new story by Tam et al. And with a title to honour Jason Cyster’s heritage.

In @jem.org, Hernández-García, Iborra and colleagues show that #plasmacytoid dendritic cells amplify the response of tissue-resident memory CD8⁺ T cells (#Trm) during viral reinfection, enhancing local #antiviral protection. rupress.org/jem/article/...

#MucosalImmunology

pDCs amplify tissue-resident memory CD8+ T cell responses during viral reinfection @jem.org
rupress.org/jem/article-...

6/6 This work was expertly led by Elena Hernández (@ucm.es/Inmunotek) and Miguel Galán (CNIC). It was only possible thanks to a remarkable collaborative effort, especially from @sancholab.bsky.social, Marc Dalod, Elena Tomasello and Santos Mañes.

5/6 In summary, our study highlights a crucial collaboration between Trm and pDCs, revealing new opportunities to enhance local immunity. Graphical abstract created with
@BioRender Iborra Martín, S. (2025) biorender.com/2nazgxd

4/6 Blocking IFN-I or depleting pDCs impaired Trm-mediated protection, both in skin reinfection with vaccinia virus and respiratory reinfection with influenza A. These cells don’t act alone: they rely on pDCs to achieve optimal immunity.