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Posts by Darren Obbard

True! I had not thought through the logic!

1 week ago 2 0 0 0

But I can pretty much guarantee that most people who work on DNA do not look at it very often! It's a bit *too* small (thin) to be recognised on sight ....

1 week ago 0 0 1 0

But, on the whole, no-one is talking about them! And certainly not at #Dros26 !

1 week ago 8 0 1 0

Although it might be better to use an actual picture of #Drosophila when mentioning #Dros26. The fly in that picture is in the family Lauxaniidae .... How many other 1000+ person biology conferences can't recognize their own organism?

1 week ago 20 1 2 2
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The official website for the 11th International Congress of Dipterology (ICDXI) has launched! icd11.biol.pmf.hr

We'd love to see you in Croatia in 2027. 🇭🇷🪰🦟

1 month ago 6 4 0 0
Cover of the March 2026 issue of Nature Ecology & Evolution. The image is inspired by Da Vinci's Vitruvian Man and depicts clonal evolution within our bodies and pathogens that affect our health via different sized circles within the man and images of microbes around the edges. There is a phylogenetic tree representing evolutionary approaches to medicine.

Cover of the March 2026 issue of Nature Ecology & Evolution. The image is inspired by Da Vinci's Vitruvian Man and depicts clonal evolution within our bodies and pathogens that affect our health via different sized circles within the man and images of microbes around the edges. There is a phylogenetic tree representing evolutionary approaches to medicine.

Our March issue is a Focus on "Evolution in medicine", out now! www.nature.com/natecolevol/...

Including research & opinion on:

➡️Somatic evolution and health
➡️Predicting intrahost evolution
➡️Collateral sensitivity during antibiotic therapy

Cover illustration by Alex Cagan @atjcagan.bsky.social

1 month ago 19 5 1 2
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Predictors of Protein Evolution in the drosophilid Immune System Abstract. The evolutionary dynamics of immune genes are shaped by diverse selective pressures, yet the relative roles of gene-level traits, functional spec

@pankajd.bsky.social & @darrenobbard.bsky.social show that immune genes overall evolve faster at the protein level, but are less prone to copy-number changes than other genes in Drosophila.

🔗 doi.org/10.1093/gbe/evag034

#genome #evolution #drosophila

1 month ago 3 4 0 0
Time-calibrated phylogeny of the family Drosophilidae showing major species groups, surrounded by representative adult flies that highlight the remarkable morphological diversity of this model insect group. The composite image was created using Microsoft PowerPoint. Fly photographs were taken by Darren J. Obbard and are published under the Creative Commons Attribution License with permission.

Time-calibrated phylogeny of the family Drosophilidae showing major species groups, surrounded by representative adult flies that highlight the remarkable morphological diversity of this model insect group. The composite image was created using Microsoft PowerPoint. Fly photographs were taken by Darren J. Obbard and are published under the Creative Commons Attribution License with permission.

The #fly community aims to achieve a comprehensive genomic study of the Drosophilidae family. @pankajd.bsky.social @bernardkim.bsky.social @petrovadmitri.bsky.social @darrenobbard.bsky.social present a comparative gene annotation for 301 #Drosophilidae species @plosbiology.org 🧪 plos.io/4c3pyrI

2 months ago 29 17 1 1

How does the piRNA pathway solve the self vs. non-self problem? 🧬

Since piRNAs come from single-stranded RNA, how does the cell choose the right ones? For years, "piRNA clusters" were seen as THE privileged source. But are they really special and earmarked for biogenesis? (1/19)

2 months ago 91 51 2 4
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The grownups are cute! (although more true for (e.g.) deer-nose than for rhino!)

2 months ago 1 0 0 0
Transcriptomic analysis of non-model Drosophilidae reveals novel AMP candidates #Drosophila PubMed link

Transcriptomic analysis of non-model Drosophilidae reveals novel AMP candidates
#Drosophila

2 months ago 3 2 0 0
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Single-nucleus resolution of sex-biased expression and dosage compensation in Drosophila melanogaster Abstract. In many species, sex-biased expression is widespread and thought to contribute to sexual dimorphism. While bulk RNA-sequencing has been instrumen

I enjoyed this! royalsocietypublishing.org/rspb/article...

2 months ago 1 0 0 0

Why have you chosen to illustrate this with a random fly that is quite obviously not a drosophilid?

2 months ago 6 0 1 0
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Cow Tools!

We have lived alongside cows for nearly 10,000 years.
We breed them and exploit them

It is now, only now, that we have discovered THEY CAN USE TOOLS

Here I describe our study

(paper) www.sciencedirect.com/science/arti... in @currentbiology.bsky.social
with @auersperga.bsky.social

3 months ago 1321 539 26 109
Rapid evolution and comparative analysis of piRNA clusters in D.simulans Eukaryotic genomes are ubiquitously occupied by mobile genetic elements termed transposons, which are silenced via a specialized class of small RNA called piRNA. The small RNA is produced from the transposons themselves when they occupy specialized regions of the genome termed piRNA clusters. The formation of these specialized regions, or their evolution over time, is not well understood. Recent work has suggested that they are extremely variable even within a single species such as Drosophila melanogaster. We were interested in taking a comparative approach to piRNA cluster evolution to ask the question - what processes are unique to D.melanogaster and which are shared? Shared phenomena are more likely to be fundamental aspects of piRNA formation and evolution compared to those that are more labile. Using five high-quality long-read genome assemblies and five genotype-specific piRNA libraries, we approach this question from a population genetics standpoint. We annotate piRNA clusters, transposons, and structural variants in each of these five genomes. We found extensive variation in piRNA clusters across strains, with smaller piRNA clusters more likely to be limited to a single genotype. By and large, our results are consistent with a model of piRNA cluster evolution in which piRNA clusters are rapidly formed and lost, with a small subset increasing in frequency and length over time. However, we find that the TEs which nucleate the formation of small piRNA clusters are entirely distinct in D.simulans compared to D.melanogaster, and likely reflect its invasion history rather than any inherent property of the transposon to nucleate clusters. Therefore, while large common clusters can act as 'traps' as has been posited for piRNA clusters, there are also numerous small clusters that are born and lost rapidly within a species. ### Competing Interest Statement The authors have declared no competing interest. National Science Foundation, NSF-EPSCoR-1826834, NSF-EPSCoR-2032756 National Institutes of Health, R35GM155272

If you need a little distraction from the world @prakashnarayanan.bsky.social first paper is out investigating the evolution of piRNA clusters in Drosophila simulans! Also with @kerogens101.bsky.social www.biorxiv.org/content/10.6...

3 months ago 6 6 1 0
SMBE Undergraduate Travel and Mentoring Award

SMBE Undergraduate Travel and Mentoring Award

The Undergraduate Travel and Mentoring Award provides support, advice and networking opportunities for undergraduate students (including Masters students under a 3+2 system) as they navigate their first international conference.

📨 Award applications
smbe2026.org/abstracts

#SMBE2026

3 months ago 6 9 1 0

Unfortunately I am in a meeting!

3 months ago 0 0 0 0
HLi Lab - Vacancies Openings

I am looking for a postdoc to develop high-performance algorithms in computational genomics. Email or DM me if interested. For more information, see hlilab.github.io/vacancies. RTs appreciated!

3 months ago 44 64 1 0

Although that is not a flattering picture of @evogytis.bsky.social

3 months ago 0 0 1 0
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Our new 416pp #FliesofBritainandIreland covering over 1300 species & with over 1500 photos is now being printed - due mid Feb 2026. You can still pre-order until 31 Jan bit.ly/4dqQI8Z
@flygirlnhm.bsky.social @gailashton.bsky.social
@dipteristsforum.bsky.social @georgemcgavin.bsky.social

3 months ago 40 22 2 3

There is a very simple solution ....

3 months ago 0 0 1 0
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Save the date for phylogenetics!

RNA virus Journal Club returns ( @rdrpsummit.bsky.social ) with @evogytis.bsky.social intro to his "Baltic" - python module to visualise phylogenetic trees.

January 15th (Thu) - EEST Vilnius Time 3:00 PM

Join slack for updates: join.slack.com/t/rdrp-io/sh...

3 months ago 18 8 1 2
Why I Left iNaturalist After almost 18 years, I left iNaturalist, the product and organization I helped create. I left because I don’t believe the current Leadership team is pointing the product in the right direction, and ...

Disheartening to learn that after 18 years, founder Ken-ichi Ueda has left iNaturalist, citing irreconcilable differences in the direction of the company.

kueda.net/blog/2026/01...

He has a Patreon while he figures out his next move: www.patreon.com/cw/kueda

3 months ago 66 44 3 2

Four days left to apply for two postdocs in social evolution with me and @dustinrubenstein.com

Based at the University of Bristol (UK), conducting fieldwork with wasps in Cameroon, Kenya, and South Africa.

3 months ago 22 26 0 1
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My 1st ever record of an undescribed species of #Tephrochlamys. ID confirmed. Unlike other members of the genus, this species has a pair of presutural dorsocentral bristles. #Diptera #Heleomyzidae #CemeteryWildlifeWatch recording activity on #iRecord.

3 months ago 26 5 0 0
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Persistent viral infection in the Drosophila fat body is associated with immune activation at the single-cell level Background: Viruses are ubiquitous and can spread in two main ways: vertically, which involves transmission through or associated with gametes, and horizontally, which occurs through direct contact, a...

This looks interesting! www.biorxiv.org/content/10.6...

3 months ago 5 2 0 0

"Nucleotide diversity is a poor predictor of short-term adaptive potential" - I've been waiting for so long to read this paper!

3 months ago 4 0 0 0
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Could be cf. neotestacea? (or a close relative!)

3 months ago 1 0 0 0

Lauxaniidae

3 months ago 1 0 0 0

yes, hydei! (confidence depending on where you caught them)

3 months ago 1 0 0 0