Let’s not speculate too much as to the mechanisms employed. The govt employees are soo unlikely to be the problem here.

A hint, one of them used the acronym KARMA

I’m really struggling to understand how we can assess the validity of ITE models. C for benefit requires some strong assumptions. Does anyone have a critical review?

Annals of Internal Medicine: Heterogeneity of Sepsis Presentations and Mortality Rates

🦠We call a lot of things “sepsis”

🔎Our #AnnalsofIM study examined how broad this grab bag really is

⚠️Among ~75,000 patients with sepsis, we found remarkably wide spectrum of presentations & outcomes across infection source & organ dysfunction patterns

Thread ⬇️
#medsky #emimcc #idsky #pharmsky

All I want for Christmas…is a precisely defined research question - Trials

This Christmas, 5years on from the publication of the ICH E9 Addendum on #Estimands @suziecro.bsky.social & I describe a fictitious, festive #RCT conducted by Santa to answer the question: does a reindeer’s pre-flight meal impact performance? #trials #clinicaltrials link.springer.com/article/10.1...

This a a fantastic paper thanks for sharing.

And these things end up in the literature…