All are welcome to the March @vicbiostat.bsky.social seminar.
Lee Kennedy-Shaffer from @yalesph.bsky.social will be presenting " #Estimands, Assumptions, and the Challenges of Evaluating Policies: Lessons from Staggered Adoption"
12 March, 9:30 AEDT online.
www.vicbiostat.org.au
#steppedwedge
Flyer saying Save the date for the 2025 ViCBiostat Summer School
#ViCBiostat Summer School 13-20 Feb 2026
#Causal inference
#Estimands in trials
#Cluster randomised trials
Advanced #meta-analysis
In Melbs and online.
More details to come.
www.vicbiostat.org.au
This work is designed to support trial statisticians in making informed, transparent choices in their analysis plans.
We hope it helps improve clarity and impact in trial reporting.
#ClinicalTrials #Estimands #StatisticalMethods #RCTs #QualityOfLife #CancerResearch
Struggling to understand how 12m analysis accounted for fact that more women randomised to 6m of placebo were started on suppressive antibiotics (4.5%) than women randomised to 6m Hiprex (2.4%)
Presumably these were the women most vulnerable to UTI recurrence
#Estimands @brennankahan.bsky.social
Feeling the holiday spirit faded this #BlueMonday? Brighten your day and understand the joy of #estimands in a trial led by Santa—because estimands aren’t just for Christmas! trialsjournal.biomedcentral.com/articles/10....
Do mince pies or carrots improve reindeer performance?🥕🥧How can #Estimands help to ensure #Trials answers the question of interest -despite reindeer shenanigans 🦌? Estimands explained this #Christmas in trialsjournal.biomedcentral.com/articles/10....
#AcademicSky #StatsSky #EpiSky #MedSky #SciComm
🎄All I want for Christmas…is a precisely defined research question! This festive paper by ICTU’s @suziecro.bsky.social & @rachpips.bsky.social uses Santa's reindeer to explain the importance of using #Estimands in clinical trials🦌🎅 trialsjournal.biomedcentral.com/articles/10....
Do carrots or mince pies improve reindeer performance? 🦌 & how can #estimands help Santa's delivery improvement research programme? Find out in ✨All I want for Christmas… is a precisely defined research question ✨
trialsjournal.biomedcentral.com/articles/10....
This Christmas, 5years on from the publication of the ICH E9 Addendum on #Estimands @suziecro.bsky.social & I describe a fictitious, festive #RCT conducted by Santa to answer the question: does a reindeer’s pre-flight meal impact performance? #trials #clinicaltrials link.springer.com/article/10.1...
This #Christmas 🎄 5 years on from the publication of the estimand framework in the ICH E9 (R1) addendum @rachpips.bsky.social & i hope that this festive light-hearted article will facilitate understanding & application of the use of #Estimands in #ClinicalTrials
🥕🥧 Carrots or Mince pie: what fuels Santa's reindeer best? Find out & understand the importance of #estimands to clearly specify trial research questions in ✨All I want for Christmas…is a precisely defined research question✨🎅
shorturl.at/qMB6Y #Trials
#AcademicSky #StatsSky #EpiSky #MedSky #SciComm
New lingo for old problems?
I discuss the implications of the estimands framework for old problems of working with aggregate level data using a well known intercurrent (post-randomization) event in treatment switching (cross-over) in oncology as an example
#Estimands
#EvidenceSynthesis
I think this is a next/ remaining frontier for pragmatic #RCTs in this area and the concept of #Estimands* could potentially help here, as an approach to link several elements for trial and intervention planning
jpro.springeropen.com/articles/10....
They do this by providing a flexible approach that can be tailored to each individual trial. This can be seen in how the #estimands were defined for the emergency bowel and cancer trial examples in our paper 9/9
www.bmj.com/content/384/...
Instead of using blanket terms like “ITT” and “per protocol effect”, which don’t apply to many trials, #estimands allow investigators a simple way to define the treatment effect they want to estimate. 8/n
One thing that comes out from our new primer on #estimands is that descriptions such as “intention-to-treat effect” or “per protocol effect” to describe the research question can be problematic 1/n www.bmj.com/content/384/...
