‘Science needs defending’: record number of researchers run for office in US mid-terms Many Democrats making the switch to politics are motivated by the Trump administration’s cuts to science — whereas energy and AI are a pull for some Republicans.

An unprecedented number of US scientists are trading in their lab coats to run for office in the US mid-term elections in November.

go.nature.com/3QePHLk

hiPSC-derived ETV2-engineered Endothelial Cell modeling of microvascular defects in Rett syndrome

MECP2 mutation

⏫Vascular Permeability in 3D hydrogel

microRNA-mRNA profiling

#MolPsychiatry 2026
www.nature.com/articles/s41...

The vascular network in developing embryos follow a similar geometric fractal pattern across species and development stages.

More here: www.biorxiv.org/content/10.6...

Paraspeckle condensation is controlled via TDP-43 polymerization and linked to neuroprotection - Nature Cell Biology Hodgson, Huang, Lang et al. show that TDP-43 limits ribonucleoprotein particle condensation into paraspeckles in a concentration- and polymerization-dependent manner. They also link paraspeckle conden...

☕Hodgson, Huang, Lang et al. show that TDP-43 limits ribonucleoprotein particle condensation into paraspeckles in a concentration- and polymerization-dependent manner. They also link paraspeckle condensation to stress response and neuroprotection.
bit.ly/3QBQmXa

#MultisystemicSmoothMuscleDysfunctionSyndrome

Smooth Muscle Cell Acta2 R179H transgene🐭(🧐Age😎)
⏬Cerebral artery curviness, innerφ, contractile markers
⏬SNP & PE vasoresponse
⏬Cerebral blood flow ⏫Survival uni carotid occlusion
⏬White matter myelination

bioRxiv 2026
www.biorxiv.org/content/10.6...

The next Society for Developmental Biology Ethel Browne Harvey Postdoctoral Seminar will be held this Friday, April 10 at 3 pm Eastern Time. It will feature Joaquín Navajas Acedo (Biozentrum at the University of Basel) and Yiqun Wang (University of California, San Diego). The SDB Ethel Browne Harvey Postdoctoral Seminar Series is free and open to anyone interested in developmental biology and supporting the great work our postdocs are doing. Speakers Headshot of Joaquín Navajas Acedo Joaquín Navajas Acedo Biozentrum at the University of Basel "Spatiotemporal emergence of somatosensory neuron diversity in zebrafish" Headshot of Yiqun Wang Yiqun Wang University of California, San Diego "Asymmetric mRNA partition mediated embryonic patterning in spiralian development revealed by spatial transcriptomics"

Look out world--check out these great upcoming talks!

☕Hoffmann et al. show that the glycolytic intermediate fructose-1,6-bisphosphate, which accumulates in the absence of aldolase, regulates focal adhesions by relieving RCC2-mediated Rac1 inhibition.
bit.ly/3NLbU2T

rdcu.be/fbEiO

So sorry for your loss Becky💔

The unphosphorylated, closed form of ezrin binds to RNA to maintain a metastatic phenotype in osteosarcoma cells Unphosphorylated ezrin is not dormant but rather binds to RNAs to regulate transcription and translation.

Researchers in #ScienceSignaling have found that the closed form of the protein ezrin is functional instead of being inactive as previously assumed—and that this form may promote the metastasis of bone cancer cells. https://scim.ag/478qMPi

Logo for the Zebrafish Disease Models Society (ZDMS). There's two silhouettes of fish that are swimming (one blue, one black)

Hello, Bluesky community! ZDMS promotes the study, research & use of zebrafish disease models throughout the world while fostering diversity among the zebrafish community. We also advocate for public awareness of the importance of the field & offer informed opinions. Give us a follow, for more! 🐟👩‍🔬

Knock knock, no one’s there. Study finds scientists’ jokes mostly fall flat Survey examines how often academics attempt jokes during conference talks — and how these attempts at comedy land.

A chemist, physicist, and biologist walk into a bar

go.nature.com/3PfmrDS

It's out! Happy to present ITEC, a semi supervised algorithm with an extremely low error rate that can track cells in files of any size (think Terabytes!). We used it in many organisms, including zebrafish, to study how organs form and linked it to gene expression www.biorxiv.org/content/10.6... +🧪

A mouse model of Nose bleeding
#HereditaryHemorrhagicTelangiectasia

Bmx+ Endothelial Cell ALK1 KO🐭

+🧠microhemorrhage
Arterial tortuosity, ectasia
Arteriolar smooth muscle cell wrapping defects
⏬pial/mesenteric arterial tone

@mfnavedo.bsky.social #CircRes 2026
www.ahajournals.org/doi/10.1161/...

Cytoplasmic mRNA decay by the antiviral nuclease RNase L promotes transcriptional repression RNase L, which promiscuously degrades cytoplasmic RNA, is an important effector of antiviral responses. Mao et al. demonstrate that RNase L activation leads to a repression of transcription, uncovering a significant additional strategy by which RNase L reshapes the cellular gene expression environment.

Cytoplasmic mRNA decay by the antiviral nuclease RNase L promotes transcriptional repression

Pia-FLOW😎
#SCiArt

11 x 11 mm wide-field covering the whole Pial microvascular network of adult mice
Vessel connectome rewiring -/+ MCA occlusion (thrombin)

No cranial window required

Segment calvarial from pial microcirculation

@brunoweberlab.bsky.social #PNAS 2024
www.pnas.org/doi/10.1073/...

Whole-embryo spatial transcriptomics at subcellular resolution from gastrulation to organogenesis Gene expression patterns underlie development, but their systematic detection in whole embryos has remained elusive. We introduce a whole-embryo imaging platform using multiplexed error-robust fluores...

Just published in @science.org
Whole-embryo spatial transcriptomics at subcellular resolution from gastrulation to organogenesis | Science www.science.org/doi/10.1126/...

Excited to share my new preprint from the McKinley lab, where we explored regenerative mechanisms across menstruation and pregnancy! We thought specialized glands would regenerate everything.

We were wrong.

But the real mechanism turned out to be way cooler :) 🧪🧵
www.biorxiv.org/content/10.6...

Ageing promotes metastasis via activation of the integrated stress response - Nature Ageing reprograms the evolutionary trajectory of KRAS-driven lung adenocarcinoma, limiting primary tumour growth while promoting metastatic dissemination through epigenetic activation of the integrated stress response, and a therapeutic opportunity in older patients is revealed.

Nature research paper: Ageing promotes metastasis via activation of the integrated stress response

go.nature.com/4uoWp0M

Concept of tunable local translation in Ashbya❤️ so inspiring !👇🏼👇🏼👇🏼

We've extended the deadline to MARCH 15! If you have a manuscript, short grant proposal, or job application & want a fresh, unbiased, and informed perspective & belong to an underrepresented group - PLEASE APPLY! We want to support you! Please share far & wide 😊https://lifescienceeditors.org/apply/

How Congress can restore the independence of US science Members must go beyond reinstating US government research spending and re-establish decentralized governance at the National Institutes of Health and other agencies.

Congress must go beyond reinstating US government research spending and re-establish decentralized governance at the NIH and other agencies, says sociologist Natalie B. Aviles.

go.nature.com/4bCwTNh

NEW IZFS Webinar! From Code to Coat: The 'complete' zebrafish genome and the developing epidermis. Join Shawn M. Burgess (@burgesslab.bsky.social) and Mahendra Sonawane at 10:00 am EDT on March 19th! Register today at www.izfs.org/education/webinars #IZFSWebinar2026 #Genome #ZebrafishResearch

An extracellular vesicle-mediated mitochondrial transfer network critical for testosterone synthesis - Nature Cell Biology Xia, Zhang, Peng, Chen et al. find that Leydig cells and macrophages show bidirectional mitochondrial transfer through extracellular vesicles, ensuring Leydig cells have functional mitochondria. The e...

☕Xia, Zhang, Peng, Chen et al. find that #Leydig cells and macrophages show bidirectional mitochondrial transfer through #ExtracellularVesicles, ensuring Leydig cells have functional #mitochondria. The exchange is needed for testosterone production.
bit.ly/40US4Vy

New preprint out!
In this study, we introduce NanoFLex, a strategy that combines #HaloTag variants with #nanobodies -based immunolabeling to enable rapid, OneStep-IF #lifetime #multiplexing. Possible due to SmartSecondaries fused to #HaloTag from @nanotag.bsky.social: www.biorxiv.org/content/10.6...

🚨 New paper from our lab just published in Nature🚨

www.nature.com/articles/s41...

Discover how 🌱 tumour formation is shaped by tissue context from the very beginning. Cancer is not driven by genetics alone

✨Fantastic team led by Greta Skrupskelyte, Eduardo Rojo, @hariajith.bsky.social

Lymphatic disruption drives lung transplant fibrosis through interleukin-1–mediated hyaluronan accumulation Interleukin-1–mediated hyaluronan synthesis in transplanted grafts promotes fibrotic remodeling because of lymphatic disruption.

New work deciphers how disruptions to #lymphatic drainage drive fibrosis in transplanted lungs and hearts through the accumulation of hyaluronan—and identifies potential therapeutic targets to prevent lung fibrosis in mice. #ScienceTranslationalMedicine https://scim.ag/3ONyh7H

Keeping cells fit Fragments of aberrant cytoplasmic mRNA pair with nuclear RNAs to augment transcription

In a new Science study, researchers report on transcriptional adaptation, a dual feedback and feedforward mechanism that uses genetic redundancy to compensate for mutations in protein-coding genes.

Learn more in a new #SciencePerspective: https://scim.ag/4ryeXtN

Thanks of sharing ‪@phnglab.bsky.social, I almost missed it!!!
👏🏼👏🏼👏🏼

Historically Black US universities chase top research ranking Howard University is reaping the rewards of becoming the first such institution to reach ‘R1’ status.

Howard is the only historically Black college or university in the United States to have landed the coveted title of an R1 research university

go.nature.com/4tRldOI