Cozy day for some transposon research 🤍❄️

#LundUniversity #snow

Always a joy to join #EMBOMobileGenome -A week full of cool nature’s quirks and science along the friendliest crowd 🧬 Happy to have shared our work on ERVs in human brain evolution (talk by @jakobssonlab.bsky.social) and Parkinson’s disease (poster by yours truly) 🧠
#ASAP @jakobssonasap.bsky.social

#EMBOMobileGenome Session 2 on transposon regulation 🧬

➡️'Epigenetic control of transcribed retroelements by the HUSH complex and associated factors' presented by Christopher Douse (Lund University, Sweden)

We love a good Q&A session as well! 🙋🏼

@chdouse.bsky.social @lundstem.bsky.social @embl.org

Had an absolute blast presenting my “Last Minute Breakthrough talk” at #EMBOmobilegenome today! 🔥 What an incredible crowd, the energy in the room was unreal. Huge thanks to the organizers for selecting me and to everyone who came, asked questions, and made it such a fun session! 🙌

@raquelgarza.bsky.social from the Jakobsson Lab presented our recent work on single-cell omics (transcriptomics+ proteomics) within our ASAP project at the SciLifeLab Lund day. This work is being done in collaboration with #BioMS and @scilifelab.se. We are looking forward to the discoveries ahead 🌟

Thrilled to share our story in its final form! nature.com/articles/s41... 💥 After ~10 years, we show that BMAL1 represses transposons via chromatin regulation in embryonic stem cells—rather than circadian rhythms as in adult tissues.

💥 New preprint! 💥
We show that transposons are directly linked to a cell-type and region specific inflammatory state in Parkinson’s Disease 🧠🦠

What a team @jakobssonasap.bsky.social! Funded by @asapresearch.parkinsonsroadmap.org

#Parkinsons #Neuroinflammation #TEworldwide #singlecell #TEs

Cheers @anitaada.bsky.social for some more awesome science together 🍾🌟

Check out our latest work on L1 retrotransposons and their cis acting effect in early brain development 🧠 www.cell.com/cell-genomic...

Excited to share our latest work!! 🌟🌟

Thank you for all the amazing work and congratulations to @anitaada.bsky.social and all the coauthors! 🍾

LINE-1 retrotransposons mediate cis-acting transcriptional control in human pluripotent stem cells and regulate early brain development Adami et al. demonstrate that evolutionarily young L1s are expressed in human pluripotent stem cells and are dynamically regulated throughout neural differentiation. The study examines the role of L1s...

New paper from our lab! We found that LINE-1 transposons contribute to early human brain development.

Funded by @asapresearch.parkinsonsroadmap.org

www.cell.com/cell-genomic...

Long-read RNA sequencing of transposable elements from single cells using CELLO-seq - Nature Protocols Single-cell long-read RNA sequencing enables the high-fidelity mapping of single-cell expression data from highly sequence-similar transposable elements to unique genomic loci by correcting errors fro...

Very happy to share our protocols paper for CELLO-seq. This will make single cell long read RNA-seq more accessible and provides analysis guidelines. We hope this helps the #transposon #TEsky community and folks working on #singleCell isoform and allelic #gene expression. doi.org/10.1038/s415...

⏰ Abstract deadline for 'The mobile genome' is 29 July!

👉 https://s.embl.org/mge25-01-bl

Join us 4–7 Nov 2025 at EMBL Heidelberg (or online) to explore the impact of TEs across biology. 🧬🔍

⭐🧑🏼‍🔬 24 talks + 15 flash talks from posters – don't miss out!

#EMBOMobileGenome

These past 2 months as a visiting scholar at KU Leuven flew by! It has been so enriching to work side by side with #TeamVoet on @jakobssonasap.bsky.social research into Transposable Elements & Parkinson’s Disease 🧠🧬 Excited for what’s next!

#ParkinsonsDisease #MJFF #ASAP #CRN #TransposableElements

Loss of H3K9me3 maintenance in human neural progenitor cells leads to transcriptional activation of L1 retrotransposons Heterochromatin is characterised by an inaccessibility to the transcriptional machinery and associated with the histone mark H3K9me3. Heterochromatin erosion is a hallmark of human ageing and H3K9me3 ...

New preprint from our lab! Why is not everyone working on Transposons?

Loss of H3K9me3 maintenance in human neural progenitor cells leads to transcriptional activation of L1 retrotransposons

www.biorxiv.org/content/10.1...

Last week, some of us from Team Jakobsson had a great time in Arizona at the 2025 CRN Collaborative Meeting! Plenty of insightful talks and networking. Shoutout to @kirkebylab.bsky.social for a fantastic talk on PSC-based therapies and models of PD 🌟🧬🏜️ #CRNPhoenix2025 @asapresearch.bsky.social

Popcorn worthy research at #CRNPhoenix2025 with
@jakobssonasap.bsky.social 🍿

#ParkinsonsDisease #PD #TEsky

ALS molecular subtypes are a combination of cellular and pathological features learned by deep multiomics classifiers O’Neill et al. present a deep exploration of molecular subtypes in ALS postmortem tissues from the NYGC ALS Consortium. Matched bulk and single-cell profiles demonstrate that ALS subtypes are a combin...

Super happy to announce the latest work from my lab together with Hemali Phatnani @nygenome.org & NYGC ALS Consortium!

We've combined ALS patient profiling (100s!), ML classifiers and matched bulk/single-cell data to dive into ALS Molecular Subtypes

#NIHfundedResearch
www.cell.com/cell-reports...

In this paper, CRN Team @jacksonlab.bsky.social found that LINE-1 transposable elements contribute to the complexity of the transcriptome in human pluripotent stem cells by acting as alternative promoters for approximately 100 genes.

Check out the full #preprint: shorturl.at/TJ9BK

Congrats @marliesoomen.bsky.social! 🧬🍾 Had been looking forward to see this paper since I heard of it in CSHL 🍂 Having it for JC next week 🤓

🧠🔬 Great meeting last Friday in Copenhagen between the Kirkeby and Jakobsson labs — exciting experiments coming up to investigate transposons in PD in vitro models! @asapresearch.bsky.social @kirkebylab.bsky.social @jakobssonlab.bsky.social

We profiled the effects of our CRISPRi system targeting young L1 elements in human pluripotency & brain development. These elements deeply impact our transcriptome, but also have very distinct effects on their nearby genome. Check it out!! 🧬👾

#TEsky #CRISPR #L1 #development #epigenetics

CSH Asia is organising its first transposon meeting. Don't miss out on some great science and a fantastic trip. Abstract deadline fast approaching.
www.csh-asia.org?content/2544

Secret santa @jakobssonlab.bsky.social 🧬🎄

Tracking transposable element (TE) activity in genomics data can be a pain, but there are solutions! Our lab built TEtranscripts -- which we've updated to work for small RNAs (TEsmall), bulk RNA at the locus level (TElocal), and in single-cell data (TEsingle). Check it out!

www.mghlab.org/software

Thank you Geoff!! 🌟

💥🦊 So proud of being part of this team!

Nice! Could you add me please?

🧬 🧠 Excited to see it printed! We bring key insights on the epigenetic regulation of SVAs, including SVA-XDP: a polymorphic SVA driving a rare neurodegenerative disorder

@jakobssonlab.bsky.social @vivienhorvath.bsky.social
#TEworldwide #Transposons #XDP #NSMB
+ the volume has the cutest cover 🦔

Gorgeous. Plain gorgeous jumping genes 💜👾🧬

#TEsky

Today we are showing high school students how cool things we can do using #nanopore sequencing at the #unistemday at the Lund Stem Cell Center 🧬👩‍🔬🦠🧪