Had a great time hosting @proteincapsid.bsky.social over the past few days. Thanks for the exciting lecture and for sharing your tomography expertise. Until next time!

Thrilled, and admittedly relieved, to see this major investment in Dutch #cryoEM become reality! 🇳🇱🔬

Honoured to be a co-applicant on this national initiative and very excited for the opportunity to advance our work in cellular structural virology! 🦠

www.uu.nl/en/news/33-m...

Development of a live-cell imaging assay to elucidate spatiotemporal dynamics of extracellular vesicle fusion with target cells Cells communicate via extracellular vesicles (EVs) containing functional RNAs, proteins and lipids. Knowledge on the fate of internalized EVs, especially their capacity to fuse with target cell membra...

"Development of a live-cell imaging assay to elucidate spatiotemporal dynamics of extracellular vesicle fusion with target cells"

www.biorxiv.org/content/10.1...

Interested in our recent norovirus NS3 work? 👇

Join us to dig deeper!

I'm recruiting a PhD candidate to investigate NS3's role in viral replication and assembly using #cryoEM, #cryoET, and other complementary techniques.

🔗 tinyurl.com/4f3t3aae

Please share! 🙏

Latest preprint from the lab, many years in the making!

By combining #cryoEM with #AlphaFold3 modelling, we propose that norovirus NS3 forms a transmembrane RNA translocase.

This could have big implications for our understanding of viral replication & assembly (🧵)

www.biorxiv.org/content/10.1...

Think coronavirus spikes have run out of surprises? Think again.

Our latest preprint dives into the highly unusual spikes of marine mammal coronaviruses.

www.biorxiv.org/content/10.1...

This #cryoEM study was led by @viralfusion.bsky.social, with key contributions from an amazing team.

I’m delighted that we could contribute the #cryoEM data to this incredible antiviral discovery project from the group of @neytsjohan.bsky.social 💊

"A coronavirus assembly inhibitor that targets the viral membrane protein"

www.nature.com/articles/s41...

A huge congrats to everyone involved! 🎉

More picornavirus research from us! 😄

The critical role of enterovirus 2A protease in viral translation, replication, and antagonism of host antiviral responses Enteroviruses dramatically remodel the cellular infrastructure for efficient replication and curtailing host antiviral responses. Proteases 2Apro and 3Cpro have been implicated in these processes base...

Latest #virology research from the lab! 👇

Using genetic approaches and live-cell imaging, we show that the viral 2A protease plays a critical role in subverting antiviral responses and establishing a favorable host environment to expedite enterovirus replication.

www.biorxiv.org/content/10.1...

Postdoctoral Researcher in Structural Virology This project is focused on deciphering the role of virally encoded AAA+ ATPases in the replication cycles of Enteroviruses and Noroviruses.

I’m looking for a postdoc to join my team under a recently funded ERC Starting Grant.

If you’re passionate about structural #virology and have experience in #cryoEM SPA and/or #cryoET, get in touch!

Application deadline: January 19th.

Please share with your networks 🙏

Job link: tiny.cc/7v33001

Postdoctoral Researcher in Structural Virology This project is focused on deciphering the role of virally encoded AAA+ ATPases in the replication cycles of Enteroviruses and Noroviruses.

www.uu.nl/en/organisat...

Streamlining segmentation of cryo-electron tomography datasets with Ais pubmed.ncbi.nlm.nih.gov/39704648/

Poliovirus keeps popping up in European wastewater, perplexing and worrying scientists Origins and spread of the vaccine-derived viruses remain mysterious

Poliovirus keeps popping up in European wastewater, perplexing and worrying scientists www.science.org/content/arti...

Amazing science at the Science for Life meeting in Utrecht. The talk by Julia Mahamid was incredible; it most definitely helped me to secure a poster prize too!

me too @danielhurdiss.bsky.social

Excited to share our first preprint of 2024! 🎉

researchsquare.com/article/rs-3...

This study focuses on PDCoV, an emerging enteric pathogen.

We generated anti-spike mAbs & investigated their inhibitory mechanisms using structural & functional studies.

#virology #cryoEM

Our #TeamTomo adventure continues! 🔬

Here is Bob's first attempt running MemBrain-seg on one of his tomograms 😍

@bobcoelingh.bsky.social