Marvellous illustration of #alphafold3 structures and proposed multimeric models!

AI Drug Discovery Just Entered Clinical Trials—Here's What That Means AlphaFold3 expanded AI's reach beyond proteins to entire molecular systems. Now AI-designed drugs are in human trials with clinical data. The timeline just comp

AlphaFold3 didn't just speed up drug discovery—it skipped like five years of the timeline entirely.

AI Drug Discovery Just Entered Clinical Trials—Here's What That Means AlphaFold3 expanded AI's reach beyond proteins to entire molecular systems. Now AI-designed drugs are in human trials with clinical data. The timeline just comp

AI just skipped like five years of waiting around.

🤖 Outperforms humans in science/math.
🧬 Predicts complex molecules.
⚡ Automates AI research.
📜 New global AI rules.
#AIBreakthroughs #SuperhumanAI #AlphaFold3 #AutoAI #AIRegulation
View in Timelines

The Isomorphic Labs Drug Design Engine unlocks a new frontier beyond AlphaFold - Isomorphic Labs Today, we are excited to share an update on our progress towards a new frontier of drug design. We have unlocked a new paradigm of predictive accuracy in understanding our biomolecular world, allowing...

" #IsomorphicLabs Drug Design Engine (IsoDDE), a unified computational drug-design sys., progressing beyond #AlphaFold3 in its predictive accuracy & with new capabilities which bridge the gap between structure prediction & real-world drug discovery."
www.isomorphiclabs.com/articles/the...

X is no longer the place for serious humanitarian coordination. I’m bringing the mission here. >
Right now, the open-source community is sitting on the most powerful biological tool in history: #AlphaFold3. I am looking to coordinate a virtual summit to apply this tech to the Gaza health crisis

AlphaFold3 for Structure-guided Ligand Discovery #molecularmodeling #alphafold3 #docking #vhts #cofolding

AI protein-prediction tool AlphaFold3 is now more open The code underlying the Nobel-prize-winning tool for modelling protein structures can now be downloaded by academics.

AI protein-prediction tool AlphaFold3 is now more open www.nature.com/articles/d41... #science #openscience #reproducibility #alphafold3

Durante el workshop aprenderás a:

🔹 Analizar estructuras de proteínas con #ChimeraX
🔹 Predecir modelos con #AlphaFold3
🔹 Diseñar proteínas artificiales (de novo protein binders)
🔹 Entender cómo la #IA transforma la biología estructural

Este taller te guiará desde los fundamentos de la estructura de proteínas hasta las herramientas modernas de predicción y diseño, con foco en #AlphaFold3 —la tecnología galardonada con el Premio Nobel de Química 2024

#Google is going to win the #AI race, as they are a real company. #SRL is a new twist on #AI learning. They quietly release killer apps like #NotebookLM, #AlphaFold3, #Jules, and have #DeepMind to work out hard frontier issues.
Long term, bet on Google.
#AI #TrueIntelligence
youtu.be/ANICPVqJ2ps?...

AlphaFold3 prediction of protein-protein complex: Is it ready for thermodynamic analysis?. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.10.015

🔗 AlphaFold3 prediction of protein-protein complex: Is it ready for thermodynamic analysis?. Computational and Structural Biotechnology Journal, DOI: doi.org/10.1016/j.cs...

📚 CSBJ: www.csbj.org

#AlphaFold3 #ProteinDesign #MolecularModeling #ComputationalBiology #StructuralBiology #Thermodynamics

Have a look at my newest Workshop! The first Video is online now. It is about #alphafold3 and how it helps scientists to achieve more meaningful results faster. This video, as well as the whole workshop is available in English and German.

youtu.be/hJCAqh_DVFI

Reposting with pride!! Big credit to Maria Mina (@katsilalab.bsky.social star), Spyridon-Marios Giatro & Dr Minos Matsoukas. Oct4 "handshakes" via #AlphaFold3. 332 interactors screened; 15 higher-ipTM dimers; 72 confident contacts; phospho states hint alt PPIs. #Bio3_Forum_2025

AIが解明したヒトの苦味受容体の三次元構造とその課題 芝浦工業大学の研究グループがAlphaFold3を用いて、ヒトの苦味受容体25種類の構造を高精度に予測しました。これにより生活習慣病の予防や新たな研究の可能性が広がります。

AIが解明したヒトの苦味受容体の三次元構造とその課題 #東京都 #江東区 #芝浦工業大学 #苦味受容体 #AlphaFold3

芝浦工業大学の研究グループがAlphaFold3を用いて、ヒトの苦味受容体25種類の構造を高精度に予測しました。これにより生活習慣病の予防や新たな研究の可能性が広がります。

Structure of Pex8 in complex with peroxisomal receptor Pex5 reveals its essential role in peroxisomal cargo translocation Peroxisomes are essential cellular organelles that enable the sequestered execution of a broad range of metabolic processes. Due to the lack of an internal protein synthesis machinery, they entirely d...

Our latest bioRxiv preprint on the molecular mechanisms underlying #Pex8's essential role in Peroxisomal Protein Import

A huge thanks to all authors and collaborators for their crucial support! 🙏

doi.org/10.1101/2025...

#Peroxisome #ProteinImport #CryoEM #XLMS #SAXS #Crystallography #AlphaFold3

Alphafold 3 guided insights into the Importin b / Importin 7 heterodimer interaction and its binding to Histone H1
Dickmanns, A., Dybkov, O. et al.
Paper
Details
#Alphafold3 #ProteinInteractions #HistoneBiology

Using #AlphaFold3, we predicted the structure of HSV-1 pUL21 and VZV pORF38 in complex with PP1. Surprisingly, the TROPPO motif binds the same hydrophobic groove as cellular RVxF and ϕϕ[xF] motifs. Strikingly, a disordered linker region of pUL21 is predicted to become ordered upon PP1 binding.

*Shedding light on the structure-function mechanisms of LRR-RPs. Our research merges #AlphaFold3, years of literature and functional validation to reveal diverse ligand-binding mechanisms and a conserved co-receptor association mechanism.

Shedding light on the structure-function mechanisms of LRR-RPs. Our research merges #AlphaFold3, years of literature and functional validation to reveal diverse ligand-binding mechanisms and a conserved co-receptor association mechanism. www.biorxiv.org/content/10.1...

A nifty trick our lab is using to improve structure prediction of viral membrane proteins in #AlphaFold3! 👇

Initial #AlphaFold3 predictions of the NTD were just as disappointing as our earlier AF2 attempts.

Then we had a brainwave 💡— what if we included fatty acids to mimic the membrane bilayer?

At this point, the missing piece of the puzzle was the N-terminal membrane-binding domain, which we had replaced with a soluble hexamerization domain to enable structural studies 🧩

To understand the full picture, we turned to #AlphaFold3.

Latest preprint from the lab, many years in the making!

By combining #cryoEM with #AlphaFold3 modelling, we propose that norovirus NS3 forms a transmembrane RNA translocase.

This could have big implications for our understanding of viral replication & assembly (🧵)

www.biorxiv.org/content/10.1...

ASC 2025: Bigger, Harder, Higher, and Just Better I’ve been to a lot of student cluster competi...

www.hpcwire.com/2025/06/02/asc-2025-bigg...

#Features #alphafold3 #ASC #student #competition #FAMIL #Geant4

Result Details

How sugar fuels ATP production in the mitochondrion | National Institute of Neurological Disorders and Stroke (NINDS) posted on the topic | LinkedIn Ever wonder why sugar gives us such an energy buzz? Its breakdown product, pyruvate, fuels ATP production in the mitochondrion. Dr. Lucy Forrest, an #NINDSIntramural investigator, and collaborators re...

Are you wondering how sugar is used to fuel your body? Work with @mitocarriers.bsky.social and Vanessa Leone describes an important step along the way... how the break-down product pyruvate gets into the mitochondria!

A very satisfying application of #alphafold3

www.linkedin.com/posts/nation...

DeepMind Tightens Control Over AI Research to Guard Google's Competitive Advantage - WinBuzzer DeepMind has restricted some AI research publications to protect Google’s competitive edge, marking a shift from its former open science approach.

DeepMind Tightens Control Over AI Research to Guard Google’s Competitive Advantage

#AI #DeepMind #GoogleAI #GeminiAI #AIresearch #AlphaGeometry #AlphaFold3 #AGI #AIsecrecy #RoboticsAI #TxGemma #AIethics #OpenScience #LLMs