(4/4) #XLMS results support the structural analyses done by Eva’s team, which uncovered how the #GlucocorticoidReceptor (GR) self-assembles into its active forms. This deepens into the understanding of disease-linked GR mutations and establishes a framework for designing selective GR modulators.

(3/4) We are happy to have contributed by generating the #CrossLinkingMS ( #XLMS ) data and also by using our custom data analysis workflow, which integrates the outputs of different #XLMS software like #MeroX, #xiSEARCH and #XlinkX. @irbbarcelona.org

Structure of Pex8 in complex with peroxisomal receptor Pex5 reveals its essential role in peroxisomal cargo translocation Peroxisomes are essential cellular organelles that enable the sequestered execution of a broad range of metabolic processes. Due to the lack of an internal protein synthesis machinery, they entirely d...

Our latest bioRxiv preprint on the molecular mechanisms underlying #Pex8's essential role in Peroxisomal Protein Import

A huge thanks to all authors and collaborators for their crucial support! 🙏

doi.org/10.1101/2025...

#Peroxisome #ProteinImport #CryoEM #XLMS #SAXS #Crystallography #AlphaFold3

...a comprehensive suite of tools now exists, both for the lab and for data analysis, to enable #proteinRNA #XLMS for the masses!

Validate User

As a first post, a plug for our nearly month old publication in
@narjournal.bsky.social :
academic.oup.com/nar/article/...
#XLMS #proteomics #structuralproteomics #massspectrometry #structuralbiology

EndoMAP.v1 charts the structural landscape of human early endosome complexes - Nature A study presents EndoMAP.v1, a resource that combines information on protein interactions and crosslink-supported structural predictions to map the interaction landscape of early endosomes.

Excited to share that our EndoMap project is now out! A fun collaboration with Miguel Gonzalez-Lozano from the @harperlabhms.bsky.social. Explore our #AlphaFold structural interactome of #XLMS complexes in endosomes-> endomap.hms.harvard.edu

and read about it here->
www.nature.com/articles/s41...

Proteome-scale recombinant standards and a robust high-speed search engine to advance cross-linking MS-based interactomics - Nature Methods This Article reports cross-linking mass spectrometry (XL-MS) standard datasets with fully controlled protein interactions that are an order of magnitude more complex than existing ones. These datasets...

Scout, our high speed search engine, is finally published. Additionally, we developed a standard, ground truth dataset for cross-linking Mass Spectrometry which guided the development of Scout.
#XLMS #Massspec #Proteomics

www.nature.com/articles/s41...

What are the true dimensions of a TRP channel? Read more on the TRPV4 structural ensemble and the complex regulatory network encoded within the channel's N-terminal IDR: rdcu.be/dgJ3U
#NMR #SAXS #MD #HDX #XLMS