🕛🕔🕗 Heads up! Fragile Nucleosome Seminar is at a special time this week: 2pm US West / 5pm US East / 10pm UK / 6am Tokyo / 7am Melbourne
We'll have outstanding talks on chromatin from Shabih Shakeel and @kazu-maeshima.bsky.social !!!
register here: us06web.zoom.us/webinar/regi...
Our H1 paper is out #ScienceAdvances:
www.science.org/doi/10.1126/...
@masaashimazoe.bsky.social et al. reveal that linker histone H1 acts as a liquid-like glue to organize chromatin in live cells. 🎉 Fantastic collab with @rcollepardo.bsky.social @janhuemar.bsky.social and others—huge thanks! 🙌 1/
2nd call for postdoc positions in the lab. Get in touch for more information or simply apply here: mbg.au.dk/en/news-and-...
Wake up, kids
We got the dreamers disease.
‘Radical’ comes from a Latin word meaning "root."
Because roots are the deepest part of a plant, ‘radical’ came to describe things understood as fundamental or essential.
‘Radical change’ was a change at the root of a system.
Germ cells have their own versions of core transcription factors and fertility depends on them.
We're hiring a PhD student to figure out how! 📢
Fly genetics + proteomics + genomics. Fully funded.
Aarhus University 🇩🇰
Deadline May 1 👇
Please share with anyone who might be interested!
Check out our first lab preprint: A real team effort to understand the Plasmodium GAPM proteins, which form part of a essential bridge between the parasite's cytoskeleton and motility apparatus. Below is a sneak peek of some beautiful microscopy - light and electron! www.biorxiv.org/content/10.6...
cryoEM maps of the different assemblies
New preprint
www.biorxiv.org/content/10.6...
A stepwise mechanism for RAF1 activation involving novel assemblies exclusive of HSP90 RAF clients influencing MAPK signaling. Great collaboration between our group and the groups of @jespervolsen.bsky.social and M. Barbacid @cniostopcancer.bsky.social
Awesome work. Congratulations Hongmiao!
Excited to share my postdoc work on the cryo‑EM structure of the budding yeast telomerase holoenzyme! 🧫🧬
It’s been a real privilege to be part of the awesome Kelly Lab @kellythd-nguyen.bsky.social. Grateful as well to the incredible facilities @mrclmb.ac.uk.
Proud to share the yeast telomerase structure, led by the talented @hongmiaohu.bsky.social in collaboration with the Wellinger and Chartrand labs. Discovered 37 years ago and took us nearly 7 years but totally worth the wait 😍.
www.science.org/doi/10.1126/...
www.youtube.com/watch?v=gFE4...
1/11 In our story out today in @nature.com , we showcase the molecular mechanisms that enable Cas9 to bind and cleave negatively supercoiled ((-)SC) off-targets! 🧬🧵
🔗 www.nature.com/articles/s41...
#CRISPR #Cas9 #DNATopology #AFM #CryoEM #SingleMolecule #Biophysics
This is such a cool story! I cannot stop looking at the structure with the minicircle.
💍
Congratulations Quentin and all authors!
New research in Nature shows that the physical twisting of DNA plays an important role in DNA editing mistakes made by CRISPR.
Using nanometer-sized circles of DNA, scientists captured never-before-seen interactions between CRISPR & DNA, providing insights that could eradicate errors altogether.
📣 Physicists and engineers: apply your experimental skills to biology! Join the group of Katerina Naydenova @imprs-lm.bsky.social for a #PhD to develop new technologies that enable answering fundamental biological questions. Apply NOW!
Excited to share our work on the structure and function of cytoplasmic lattices within mouse embryos. A collaborative effort with @niakanlab.bsky.social and work led by @kashishsingh.bsky.social and @inaharasimov.bsky.social . It is now out on BioRxiv: www.biorxiv.org/content/10.6...
1) The Herzik lab is excited to announce our newest preprint in collaboration with the Grotjahn lab! We have developed a surfactant cocktail that seeks to overcome one of the more nefarious problems in #cryoEM, Air-water interface (AWI)-induced damage and preferred orientation (PO).
Dave Grohl in the Guardian casually casting shade on thousands of academics
www.theguardian.com/music/2026/m...
Group picture of the lab members
With the new year, we have welcomed several new members to our lab, so it is a perfect time to update our group picture.
🔬🧬
Myself and @immunoah.bsky.social are looking to hire a postdoctoral scientist to build a next-generation high-throughput high-resolution light sheet microscope for imaging entire cleared organs/tissues and to further develop live & fixed tissue clearing methods.
www.nature.com/naturecareer...
The Sfeir Lab at MSKCC is hiring a Research Assistant!
We are looking for a motivated scientist with at least 2 years of research experience and a two-year commitment. Learn more about our work here www.sfeirlab.com, and message me your CV and cover letter if interested
🚨New paper: We found - contrary to expectations - that oxygen is partially excluded from biomolecular condensates.
We find a strong anti-correlation between oxygen and protein concentrations in the condensate showing that accessible volume dominates over polarity.
www.nature.com/articles/s41...
The campus at @au.dk is very pretty, also in the snow
Please spread the word: the Structural Studies Division @mrclmb.bsky.social is looking for a new tenure-track, independent group leader with an exciting plan in any area of Structural (Molecular & Cell) biology, in discovery biology and/or methods development. 🥳
mrc.tal.net/vx/mobile-0/...
It took a while but it’s finally published!
The GAP activity of SEAC (GATOR) is a metabolic switch that allows cells to quickly respond to changes in amino acid levels, both for inhibition and reactivation.
How could a simple self-replicating system emerge at the origins of life? RNA polymerase ribozymes can replicate RNA, but existing ones are so large that their self-replication seems impossible. Could they be smaller?
Excited to share our latest work in @science.org on a new small polymerase.
1/n
A beautifully crafted summary of the extraordinary discovery in the lab of my @mrclmb.bsky.social colleague @philholliger.bsky.social of a tiny RNA that can replicate RNA.
We’re excited to share our latest EMBO Journal paper! We show that STIM1 localizes to ER-mitochondria contact sites to promote direct Ca²⁺ flux into mitochondria, supporting mitochondrial Ca²⁺ homeostasis, respiration, and energy production
link.springer.com/article/10.1...
Very happy to say that our work on how axonemes are generated is now available on bioRxiv: www.biorxiv.org/content/10.6... - if you’ve ever wondered how the incredibly beautiful, complex structures within motile #cilia are constructed then this is for you!
