Human PARPs modify RNA nucleobases in vitro and in cells www.biorxiv.org/content/10.64898/2026.03...

CRISPR screens and quantitative proteomics reveal remodeling of the aryl hydrocarbon receptor–driven proteome through PARP7 activity | PNAS PARP7 is an enzyme that uses donor substrate NAD+ to attach a single ADP-ribose moiety onto proteins related to immunity, transcription, and cell g...

Our new paper is out! Trying to understand the molecular function of the PARP7, a PARP family enzyme with links to innate immunity and environmental toxins response. Congrats to Andrii and the rest of the team and collaborators.
www.pnas.org/doi/10.1073/...

New paper! We uncover mechanistic insights into the crosstalk between AHR (aryl hydrocarbon receptor, a transcription factor) and PARP7 (a nuclear enzyme that performs protein ADP-ribosylation). Both are promising cancer drug targets.

Big thanks to all co-authors!

www.pnas.org/doi/10.1073/...

The Company of Biologists 100 logo to the left and QR code to the right. Portrait of Liz Robertson to the left, text to the right 100 extraordinary biologists Liz Robertson Having been a Development Editor since 2003, Liz Robertson is the longest-standing Editor of The Company of Biologists’ journals still in service. She has also been a prolific Development author since 1983. Liz’s lab at the University of Oxford, UK, studies signalling and gene expression in early mammalian development. #100biologists #biologists100

We are highlighting Liz Robertson, @dev-journal.bsky.social Editor and the longest-standing Editor of @biologists.bsky.social journals, as an extraordinary biologist this week.
#100biologists

We have another postdoc position available to work on interplay between ADP-ribosylation and ubiquitination in regulation of genome stability. For this post expertise in cell biology is required.
my.corehr.com/pls/uoxrecru...

Online now - the Spotlight "Modifying the modifiers: ubiquitination of ADP-ribosylation in human cells" from @kfeijszaja.bsky.social and colleagues.

#ADPribosylation #ubiquitination #MARUbylation #crosstalk

authors.elsevier.com/sd/article/S...

We would love feedback on a new NCBI-BLAST service we are launching today: sky-blast.com

Under the hood it's the same BLAST executable and databases provided by NCBI, with a replica of the NIH's interface - providing an alternative to the US gov service that's less congested, faster & more reliable

Ubiquitin is directly linked via an ester to protein-conjugated mono-ADP-ribose | The EMBO Journal imageimageCertain E3 ligases have been found to ubiquitylate hydroxyl groups on free NAD+ and ADP-ribose in vitro, but the in vivo occurrence of this dual post-translational modification has remained ...

#MARUbylation:
@michaelnadbio.bsky.social @jnpruneda.bsky.social and colleagues find that IFN-β induces the novel post-translational modification, mono-ADP-ribosyl ubiquitylation, on several interferon-stimulated #PARPs such as PARP10, PARP7 and PARP14
www.embopress.org/doi/full/10....

The homologous recombination factors BRCA2 and PALB2 interplay with mismatch repair pathways to maintain centromere stability and cell viability Graham et al. demonstrate that BRCA2 and PALB2 protect centromere integrity in non-cancerous cells through distinct mechanisms, partly counteracting the mismatch repair factor MLH1. In cancer cells, B...

We are delighted to share our latest work, characterising the role of BRCA2 and its binding partner PALB2 at centromeres, just out in the latest issue of Cell Reports. ⬇️

www.cell.com/cell-reports...

How to Apply and Funding

Potential PhD students who are interested in working in Ivan Ahel group are welcome to apply through the ILESLA programme.
#ADPribosylation
@dunnschool.bsky.social
@ox.ac.uk

iles.web.ox.ac.uk/how-apply

We just can't stop recruiting!

Associate professor in cell and molecular biology @dunnschool, with a preference for immunology, inflammation and/or infection - all defined broadly

Come and be our colleague

Deadline 28 Feb, please spread the word

www.path.ox.ac.uk/vacancy/asso...

📣 Please share: We’re hiring a tenure-track Group Leader in Multicellular Systems to explore the molecular and cellular mechanisms driving the formation, maintenance, or destabilization of tissues, organs and organisms. Apply at: www.fmi.ch/education-ca...

How is epigenetic information inherited across generations in insects? at University of Oxford on FindAPhD.com PhD Project - How is epigenetic information inherited across generations in insects? at University of Oxford, listed on FindAPhD.com

We are advertising for a project looking at epigenetic inheritance in Drosophila at the Department of Biology, University of Oxford @oxfordbiology.bsky.social Please get in touch if you are interested! Only 1 month left to be considered for funding.

www.findaphd.com/phds/project...

PARP enzyme de novo synthesis of protein-free poly(ADP-ribose) Langelier et al. discover that PARP1, PARP2, and Tankyrase catalyze de novo synthesis of protein-free poly(ADP-ribose), or PAR, in addition to canonical protein-linked PAR. Cellular free PAR did not r...

Intriguing new paper by @mflangelier.bsky.social in the Pascal lab showing that PARP1 can generate free poly-ADP-ribose (PAR) (not attached to proteins) in vitro and in cells. In some cases PAR is attached to NAD+! #PARP #ADP-ribosylation #NAD+

www.cell.com/molecular-ce...

Cover of PLoS biology showing fruit fly wing discs stained for Wingless protein, cell death, and the anterior compartment market Ci

More #drosophila work, recently in @plos.bsky.social PLOS Biology (on the cover :))

“Wnt signaling modulates the response to DNA damage in the Drosophila wing imaginal disc by regulating the EGFR pathway” Ewen-Campen & Norbert Perrimon

journals.plos.org/plosbiology/...

interested in all things Parp and ADP-ribosylation? arguably the weirdest posttranslational modification EVER? here is a starter pack, compiled by @leunglab.bsky.social
go.bsky.app/CiRKAXJ

Important so please help spread the word...

Interested in postgrad research? Maybe do a PhD?

Oxford runs a summer internship scheme for UK students from under-represented and disadvantaged backgrounds

Stipend, free accommodation, mentoring...

Deadline 21 Feb

www.ox.ac.uk/admissions/g...