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TGFβ-Smad3 signaling restores cell-autonomous Srsf1-mediated splicing of fibronectin in aged skeletal muscle stem cells - Nature Communications Aging impairs the regenerative capacity of skeletal muscle stem cells. Here, the authors identify a stem cell-specific fibronectin splice variant and show that its cell-autonomous secretion through th...

Please check out our latest publication showing that activated #muscle stem cells depend on a niche-restricted, autoregulatory #fibronectin splice variant that is strongly affected by #aging.

🔗 www.nature.com/articles/s41...

#StemCells #SkeletalMuscle #MuSCs #ExtracellularMatrix #Splicing

4 months ago 1 0 0 0
Screenshot of Essay from Martin Schwartz on 'Why would anyone want to be a scientist'. An anniversary article from The Company of Biologists published in Journal of Cell Science.

The first few lines are: It is difficult to fathom why anyone intelligent enough to be a scientist would actually choose to be one. Doing good science requires the utmost exertion of body, mind and spirit, yet is consistently filled with failure and rejection. But, strange even to myself, I not only don't question the unfavorable risk-to-reward ratio but consider myself astonishingly lucky to be a scientist. There are three fundamental pleasures that have sustained me through 50 years of this madness.

Screenshot of Essay from Martin Schwartz on 'Why would anyone want to be a scientist'. An anniversary article from The Company of Biologists published in Journal of Cell Science. The first few lines are: It is difficult to fathom why anyone intelligent enough to be a scientist would actually choose to be one. Doing good science requires the utmost exertion of body, mind and spirit, yet is consistently filled with failure and rejection. But, strange even to myself, I not only don't question the unfavorable risk-to-reward ratio but consider myself astonishingly lucky to be a scientist. There are three fundamental pleasures that have sustained me through 50 years of this madness.

Why would anyone want to be a scientist?

Check out our new Essay from Martin Schwartz: journals.biologists.com/jcs/article/...

8 months ago 81 46 2 8
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In his memory, Western has opened an equity-based graduate scholarship. Please consider supporting his final initiative if you are able: www.westernconnect.ca/beier ; thank you for all the time you spent and laughs you shared with him. We love and miss him so much already. - The Beiers

8 months ago 66 19 2 0
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Multiomic profiling reveals that prostaglandin E2 reverses aged muscle stem cell dysfunction, leading to increased regeneration and strength Wang et al. uncover that aged muscle stem cells have blunted PGE2-EP4 signaling that is critical for their regenerative function. Treatment with exogenous PGE2 reverses age-related defects in muscle s...

New #CellStemCell paper from Helen Blau and colleagues: Multiomic profiling reveals that prostaglandin E2 reverses aged muscle stem cell dysfunction, leading to increased regeneration and strength. #Myoblue tinyurl.com/yvf4cdch

10 months ago 6 4 0 0
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Muscle stem cells in Duchenne muscular dystrophy exhibit molecular impairments and altered cell fate trajectories impacting regenerative capacity - Cell Death & Disease Cell Death & Disease - Muscle stem cells in Duchenne muscular dystrophy exhibit molecular impairments and altered cell fate trajectories impacting regenerative capacity

Congratulations to the team for this collaborative effort! 💪
www.nature.com/articles/s41...

10 months ago 6 2 0 0

Hahaha - I knew my hair would give me away 😉

10 months ago 1 0 0 0
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Our vibrant connective tissue community at the #CCTC2025 earlier this month - wonderful people and great science #ECM

10 months ago 1 0 1 0
The Till & McCulloch Meetings (TMM)

The Till & McCulloch Meetings (TMM)

🧬 Canada’s premier #StemCell and #RegenerativeMedicine research event is BACK! Join leading scientists, clinicians, ethicists, and industry leaders at #TMM2025. 🔬

📍 Ottawa, ON | 🗓️ Nov 3–5, 2025
🎟️ Register now and save with Early Bird rates — available until Sept 10, 2025!

🔗 www.tillandmcculloch.ca

10 months ago 2 2 0 0
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Congrats Frank - much deserved 👏

10 months ago 2 0 0 0
Scientific Program The 29th Annual Canadian Connective Tissue ConferenceMontreal, QC, May 26-28, 2025 Overview Download the complete program booklet: CCTC 2025 Program Booklet DATE / TIME EVENT DETAILS DAY 1 Monday, May...

Honoured to receive the Lifetime Achievement Award from the Canadian Connective Tissue Society! A testament to the great work by our fantastic lab members and collaborators over the last 25 years or so. Thank you all!!

10 months ago 47 4 14 2
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Very proud to see @simond29.bsky.social from our lab @usherbrooke.bsky.social presenting his work on laminin receptors in MuSCs at the #CCTC2025

10 months ago 1 0 0 0
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Science under siege: protecting scientific progress in turbulent times As Editors-in-Chief of The Company of Biologists' journals, we have been watching with growing concern the policy changes in the United States of America (USA) and the challenges that these are creati...

Science under siege: protecting scientific progress in turbulent times

journals.biologists.com/dev/article/...

1 year ago 79 44 2 2

It's #InternationalWomensDay and I want to give a big shout out to the many women scientists that make the world better, little by little, every day, with passion and courage. Unsung heroes like my friend @tmedwigkinney.bsky.social

1 year ago 5 1 1 0
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Abstract Submission and Registration for the 29th Annual Canadian Connective Tissue Conference #CCTC2025 in Montreal, Quebec (May 26-28, 2025) is now open.

Submission deadline is April 6, 2025. #ECM #connectivetissue

connective-tissue-canada.com/cctc-2025/

1 year ago 0 0 0 0

Resharing this list for those who joined Bsk more recently! #myoblue

1 year ago 1 1 0 0

And I am still looking for a technician... help!!
#MyoBlue

1 year ago 3 4 0 0
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Happy #InternationalDayOfWomenAndGirlsInScience !
We couldn’t be prouder to work alongside such brilliant and inspiring young scientists 🧪🔬 ...and most importantly - always up for a prank bringing 🌞 to the lab 😆

1 year ago 1 1 0 0