Sliced hiPSC Cortical Organoid (500 μm thick slicing every 4 weeks + orbital shaking culture) sustains 150 days 🤠

👉Modeling Neurogenesis, Radial Migration & Cortical Lamination
👉Minimal interior hypoxia & apoptosis

#CellStemCell 2020
www.cell.com/cell-stem-ce...

A 5-day protocol to generate hiPSC 3D Vascular Organoid😎
ETV2▶️Endothelial Cell
NKX3.1▶️Mural Cell

👉Perfusable, arteriovenous network in vivo
👉⏫Reperfusion in mouse diabetic limb ischemia
👉⏫transplanted islet performance

@meleromartinlab.bsky.social #CellStemCell 2025
www.cell.com/cell-stem-ce...

Early results from our Luxa Biotech-sponsored and #NEIfunded #ClinicalTrial are out in #CellStemCell. The trial uses an adult RPE stem cell therapy for dry age-related #MacularDegeneration.

Beautiful cover art by Dr. Yangzi Isabel Tian.

Full Text | zurl.co/gQ2bq
@cellpress.bsky.social
#NIHfunded

Human heart-macrophage assembloids mimic immune-cardiac interactions and enable arrhythmia disease modeling O’Hern et al. present a novel human heart-macrophage assembloid platform generated by integrating hPSC-derived embryonic monocytes into heart organoids. These tissue-resident macrophages regulate card...

Our new paper in Cell Stem Cell introduces human heart–macrophage assembloids — the first, highly sophisticated organoid model of immune–cardiac interactions.

#NAMs #Organoids #CardiacResearch #CellStemCell #AFib #NIH #MSU

Link to the paper: www.cell.com/cell-stem-ce...

#TissueEngineeredBloodVessel

Decellularized 👤umbilical cord artery
Seeded: #hiPSC #EndothelialCell
Bioreactor trained: pulsatile unidirec flow 15➡️5 dyn/cm2

Rat #InferiorVenaCava graft▶️
0️⃣Thrombosis
Complete repop by host EC 2 wk SMC 2 mo

#CellStemCell 2025
www.sciencedirect.com/science/arti...

Multiomic profiling reveals that prostaglandin E2 reverses aged muscle stem cell dysfunction, leading to increased regeneration and strength Wang et al. uncover that aged muscle stem cells have blunted PGE2-EP4 signaling that is critical for their regenerative function. Treatment with exogenous PGE2 reverses age-related defects in muscle s...

New #CellStemCell paper from Helen Blau and colleagues: Multiomic profiling reveals that prostaglandin E2 reverses aged muscle stem cell dysfunction, leading to increased regeneration and strength. #Myoblue tinyurl.com/yvf4cdch

Adult bi-paternal offspring generated through direct modification of imprinted genes in mammals Li and colleagues successfully generated bi-paternal mice that developed to adulthood by targeting 20 key imprinted loci. This study underscores imprinting gene abnormalities as the primary barrier to...

🧬 BREAKTHROUGH: Scientists leap forward with bi-paternal offspring!🐭 Surviving to adulthood, this genetic advance could reshape research & medicine overcoming developmental challenges. 🚀 #Science #Genetics #CellStemCell #trends #PhDlife #innovation #ScienceBreakthrough

www.cell.com/cell-stem-ce...

🎉 Happy New Year from #DrawImpacts Studio! 🎨
We’re thrilled to kick off 2025 with exciting news: our first cover of the year has been selected for #CellStemCell 's first issue of 2025!! To another year of impactful collaborations, science, and creativity—we can’t wait to see what this year brings! 🌟

Delighted to have our work led by #RichardVoit
from our group featured on the cover of #CellStemCell
today. Artwork by the amazing
@drawimpacts.bsky.social:

www.cell.com/cell-stem-ce...

Stay tuned as we work on initiating a clinical trial for this approach!

#SpatialTranscriptomics #Visium
Human Healthy Skin Wound Healing (This is a Human Trial!🥸 N=7)
D0/1/7/30

Angiogenic niche comprising #EndothelialCell Fibroblast Mφ

Mφ secretome
D1 (inflam) IL1A/B CCL7
D7 (prolif) TGFB C1QB
D30 (remodeling) IGF1 C1QB

#CellStemCell 2024
www.cell.com/cell-stem-ce...

hiPSC-derived venous #EndothelialCell #iVEC

Mesoderm progenitors+VEGFA+FGF2+RA+DAPT

MEF2C as a putative venous endothelial TF

Retain EphB4 venous marker in vivo

Modeling TIE2L914F #VenousMalformation
DRUG-seq #DeepLearning➡️Bosutinib

#CellStemCell 2024
www.sciencedirect.com/science/arti...

Chronic autoimmunity rewires metabolism in progenitors, correlating with innate immune memory formation in macrophages that increases antibacterial activity but might also aggravate autoimmune diseases?
shorturl.at/SZ1Ww

#CellStemCell