#TissueEngineeredBloodVessel

Decellularized 👤umbilical cord artery
Seeded: #hiPSC #EndothelialCell
Bioreactor trained: pulsatile unidirec flow 15➡️5 dyn/cm2

Rat #InferiorVenaCava graft▶️
0️⃣Thrombosis
Complete repop by host EC 2 wk SMC 2 mo

#CellStemCell 2025
www.sciencedirect.com/science/arti...

H&E histology + Elastin immunohistochemistry of human normal & duplicated #InferiorVenaCava

Human IVC has a very intriguing, complex adventitial structure!
Is it #TertiaryLymphoidOrgan?😆
Elastin fibers elaborated by #FibroblasticReticularCells?😁

#AnatSciInt 2025
link.springer.com/article/10.1...

Quantify in vivo #EndothelialCell proliferation
#Aorta #InferiorVenaCava
CDH5-DreER::Ki67-CrexER::R26-GFP🐭

In 8-wk🐭, 8% aortic EC are proliferative over 12-wk period
⏬in YAP1 KO or VEGFR2 KO

#Piezo1 maintains aortic EC division orientation

#CircAHA 2024
www.ahajournals.org/doi/10.1161/...