We all learnt from each other and it was real pleasure working together to understand GAPMs in plasmodium.

New preprint! Really excited to share our spatial proteomic study on Plasmodium falciparum schizonts . We used hyperLOPIT to map thousands of proteins—from apical invasion organelles to the infected red blood cell surface.

A huge thank you to all my co-authors for this great collaboration!
@ritatewari.bsky.social @davidguttery.bsky.social @zeeshanm.bsky.social @eelcotromer.bsky.social

The forgotten half of scientific thinking | PNAS The forgotten half of scientific thinking

“The idea that taking walks, reading things unrelated to your research, and hanging out with strangers in a campus pub should be considered part of the serious process of thinking, but might well meet with skepticism in practice.”

www.pnas.org/doi/10.1073/...

Many congratulations Ryuji. Your first paper on Plasmodium biology. Well done.

Happy Holi from our lab. Festival of colours. This to welcome the spring which I hope is round the corner.

📸 No one follows more etiquette rules than the Royal Family—but notice how King Charles didn’t make any smart-ass or demeaning comments about Zelensky’s attire today.

Why? Because respect isn’t about clothes—it’s about character. And that’s something money can’t buy.

A group of four COS cells - one seems to pull the other up like we all should do

The Nikon AX-NSPARC demo is gearing up at the
@ncis-marseille.bsky.social! Starting for #FluorescenceFriday with a large field-of-view confocal #cellfie of COS cells labeled for actin ⚫ endoplasmic reticulum 🟡 mitochondria 🔴 and nucleus 🔵. Fluorescence microscopy is also nice in inverted colors 🌈🧪

Fluorescence microscope image showing a protein that goes to only one flagellum

The world is full of crazy and sad news, but here is a protein that localizes to only one of the two flagella

Modes and mechanisms for the inheritance of mitochondria and plastids in pathogenic protists Pathogenic protists are responsible for many diseases that significantly impact human and animal health across the globe. Almost all protists possess mitochondria or mitochondrion-related organelles, ...

Plastids & mitochondria arose from separate endosymbioses of prokaryotes.Their prokaryotic ancestry makes them susceptible to antibiotics. Antibiotics kill pathogenic protists by targeting their plastids or mitochondria. Here we review the lop sided inheritance.

journals.plos.org/plospathogen...

The next GRC on volume Electron Microscopy is coming soon. Don't miss this opportunity and apply now as the number of seats is limited. #volumeEM

www.grc.org/volume-elect...

As I am new to bsky, please share widely (do we still say retweet?). 🙏

Many congratulations Richard and team. Great story on DNA replication.

A couple of weeks left to apply to join Development's *Pathway to Independence* programme

Support & mentoring for post-docs on the academic job market

Deadline: January 31

journals.biologists.com/dev/pages/pi...

What started out as chromosome-counting blossomed into an exciting tale of evolution at the interface between the volatile centromere and the reliable, stable cell division machinery - the latest from the brilliant Jana Helsen, now looking to start her own group!

W/ @gsherloc.bsky.social

🧪🌎

Phosphatases: from basic research to translation Phosphatases have been considered undruggable for decades. However, recent breakthroughs with the first small molecule phosphatase inhibitors for cancer immunotherapy now in clinical trials have resu…

If you’re thinking of what meeting to go to this year then check out the #phosphatase meeting in Würzburg. Lots of great speaking slots and events for junior researchers. It’s always a fun meeting meetings.embo.org/event/25-pho...

New discovery from our #CDlab reported in Cell @cp-cell.bsky.social today:
SMC motor proteins have a left-right ‘gearbox’ and can switch direction in DNA loop extrusion!

www.sciencedirect.com/science/arti...

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Nanopore sequencing reveals that DNA replication compartmentalisation dictates genome stability and instability in Trypanosoma brucei - Nature Communications A full description of trypanosome genome replication has proved elusive. Here, after genome assembly, the authors reveal compartmentalisation of DNA replication activity and stability between transcri...

DNA replication beyond the cores of megabase chromosomes of T. brucei -- some of my PhD work is FINALLY out! doi.org/10.1038/s414... thank you to @rmc9z.bsky.social @marquescata.bsky.social Emma, Dario, Kathryn, Graham and Craig!

Many thanks

Many thanks Sabrina.

Delighted to share our first manuscript on @bsky.app on a novel SUN1-ALLAN complex in Plasmodium MTOC and NE organization. Many thanks @zeeshanm.bsky.social; @eelcotromer.bsky.social; @ryanase.bsky.social ; Tony; Sarah; David F; Karine; Igor; Cyrille; Declan. Link:
www.biorxiv.org/content/10.1...

Here we are! To celebrate our arrival, here is a #trypanosome expanded ~13 times & stained for tubulin, individual cortical #microtubules can be recognised, what was only achievable by EM before. Images: Christine Girard-Blanc & Thierry Blisnick. Many thanks to @centriolelab.bsky.social for training

Royal Society fellow resigns over Elon Musk membership - Research Professional News Dorothy Bishop lambasts world’s oldest scientific academy as she quits in protest

"Any pleasure I may take in the distinction of [being a Royal Society fellow] is diminished by the fact it is shared with someone who appears to be modelling himself on a Bond villain" www.researchprofessionalnews.com/rr-news-uk-c...

Cryptosporidium is an important public health threat, and it deserves better genetic tools to study it! Here we’ve developed a targeted in vivo CRISPR genetic screen to identify parasite genes required for survival and virulence…
www.biorxiv.org/content/10.1...

Parasitology Community Meeting YouTube video by VEuPathDB

I like this plan from EupathDB - No paywall 😀. We can volunteer to pay a fee from lab budgets. And a "mortgage calculator" tool coming up in Jan to guide us estimate that fair price based on several variables like lab size and usage.
youtu.be/aSS6fiGVBG4?...

Scientists as political advocates Science, both teaching and doing, is under attack. The recent US presidential election of a person and platform with anti-science bias exemplifies this. The study of climate processes and patterns and...

"Given the current political reality and the expansion of attacks on science, it is time for scientists to be more effective, forceful, and vociferous as their own political advocates." 🧪

www.science.org/doi/10.1126/...

Mitochondrial ATP synthesis is essential for efficient gametogenesis in Plasmodium falciparum - Communications Biology Male gametocytes rely on mitochondrial ATP to fuel gametogenesis in Plasmodium falciparum.

Check out our new paper showing that male gametocytes need an active mitochondrion for gametogenesis:
www.nature.com/articles/s42...

Also, we have a big plug for our excellent new antibody marker specific for male gametocytes and gametes.
@lshtm.bsky.social🧵

Nuclear DNA replication in Leishmania major relies on a single constitutive origin per chromosome supplemented by thousands of stochastic initiation events Understanding genome duplication requires characterisation of the locations where DNA replication initiates, termed origins. Genome-wide mapping of DNA replication origins has mainly been derived from...

New preprint from others in the lab - Mapping origins of DNA replication in Leishmania.
Great work Jeziel, Gabriel, @marquescata.bsky.social, Marija, Craig, Dario and the boss!
www.biorxiv.org/content/10.1...

Only two weeks to go to the UK Vector-Borne Diseases meeting in Liverpool (3-4th December). We are full and there is no further registration for in-person attendance. Therefore, we have opened up online attendance - see here if interested. @baylism.bsky.social payments.liv.ac.uk/conferences-...

New preprint! How do cells rewire chromosome segregation during meiosis? We identify a germline-specific mRNA splice isoform for a critical kinetochore protein. This alternative protein transforms its regulatory control, contributing to proper fertility.
www.biorxiv.org/content/10.1...

Can you please add me to this list.