Mechanisms of disassembly at the actin filament pointed & barbed ends ft. @nickpalmer.bsky.social, Malgorzata Boczkowska, Grzegorz Rebowski & Roberto Dominguez (BBCB Graduate Group) @upennphysiology.bsky.social @science.org www.science.org/doi/10.1126/...
New research out in @natcomms.nature.com provides insight into the molecular mechanism of menthol-induced TRPV5 channel inhibition ft. José De Jesús-Pérez & Vera Moiseenkova-Bell (Systems Pharmacology & Translational Therapeutics) @isbupenn.bsky.social www.nature.com/articles/s41...
Congratulations to Nikolaos Sgourakis (@i3h-upenn.bsky.social), Mark Sellmyer (Radiology), @karanoelle.bsky.social (@penncancer.bsky.social) & @rdrapkin8-penn.bsky.social (OBGYN) on being named 2026 Early Detection Awardees! @themarkfdn.bsky.social @theaacr.bsky.social tinyurl.com/54pcj8dw
Cholesterol-containing lipid crystals can directly stiffen the rat steatotic liver before fibrosis ft. David Li, Rebecca Wells (@PennGIHep), Abigail Loneker, Jamie Ford (@pennengineering.bsky.social), Elaine Mihelc (@isbupenn.bsky.social) & Paul Janmey (Physiology) www.pnas.org/doi/10.1073/...
Congratulations to León Islas's and Vera Moiseenkova-Bell's lab members!!! Angélica Méndez-Reséndiz and José De Jesús-Pérez did amazing job on discovering how menthol inhibits TRPV5 channel. #cryoEM #TRPV #menthol #ColdSensation #ion #channels #calcium
www.nature.com/articles/s41...
Join the Department of Biochemistry & Biophysics, the Johnson Foundation Biophysics & Structural Biology Core Facility, & the @isbupenn.bsky.social on 3/10 for their Symposium on Analytical Ultracentrifugation! Learn more & register➡️ tinyurl.com/47s2vnmf
Seeing mechanisms of disease
Now online: “Seeing the mechanisms of disease with cryoEM” on Penn Medicine—how near-atomic views of molecules help us decode what goes wrong in illness. #cryoEM #SciComm
www.pennmedicine.org/news/seeing-...
@yiweichang.bsky.social @jrocereta.bsky.social
Freeze, image, cure
Our cryoEM feature series is live on Penn Medicine: “Freeze, image, cure.” A closer look at how we visualize biology to understand disease and speed discovery. #cryoEM #ISB
www.pennmedicine.org/news/freeze-...
Excited to share highlights of our recent discoveries by the Institute of Structural Biology at Penn Medicine. Made possible by our outstanding faculty, students, postdocs, and staff.
www.pennmedicine.org/news/freeze-...
Wishing you & yours a restful & restorative holiday break! We'll see you back online in 2️⃣0️⃣2️⃣6️⃣! 💓✨
Visualization of lysosomal membrane proteins by cryo electron tomography ft. @bridget_mcveigh, José De Jesús-Pérez, @moiseenkovabell (@PennSysPharmATT), Prerana Gogoi, @MageswaranKumar & Elaine Mihelc (@isbupenn.bsky.social) @natcomms.nature.com www.nature.com/articles/s41...
Congratulations!!!
Excited to share our latest @nature.com: How does naloxone (Narcan) stop an opioid overdose? We determined the first GDP-bound μ-opioid receptor–G protein structures and found naloxone traps a novel "latent” state, preventing GDP release and G protein activation.💊🧪 🧵👇 www.nature.com/articles/s41...
We’re proud to celebrate our institute associate director, Dr. Yi-Wei Chang, for being named the 2025 recipient of the Michael S. Brown New Investigator Research Award.
@yiweichang.bsky.social
Congrats Bridget McVeigh, José De Jesús-Pérez, Elaine Mihelc & Vera Moiseenkova-Bell on your first cryoET publication "Visualization of lysosomal membrane proteins by cryo electron tomography" #cryoET #lysosomes #TRPML1
www.nature.com/articles/s41...
Happy to announce "Technical Innovations Using #SerialEM: A Community Meeting", a new format of hybrid meeting David Mastronarde and I are organizing in April 2026. For more info, a preliminary list of speakers, pre-registration etc. visit
www.nexperion.net/semcm2026
Congratulations!!!
...and big thanks to @jiwasa.bsky.social for making this amazing video to illustrate the strand-sliding mechanism!
Excited to share our new @science.org paper! Led by postdocs Ruchao Peng and Xin Xu, we used cryo-EM/ET to reveal the influenza ribonucleoprotein complex structure and its strand-sliding mechanism for RNA synthesis, paving the way for new antivirals.
www.science.org/doi/10.1126/...
Congratulations to Drs. Lynch, Burslem, Marmorstein, Yi-Wei, and the entire research team on the publication of your latest research article in the newest issue of Science magazine! | Science www.science.org/doi/10.1126/...
Join the Institute of Structural Biology on 5/21 for the 4th Structural Biology Symposium! Learn more & register➡️ isb.med.upenn.edu/4th-structur... @BB_UPenn
🔬 The 4th Structural Biology Symposium is almost here!
Don’t miss out—there’s still time to register.
bit.ly/4iM5QAm
Excited to see this out in @science.org today!! www.science.org/doi/10.1126/...
Congratulations to Roberto Dominguez and his lab on their latest Nature publication: "Mechanism of actin filament severing and capping by gelsolin"! 🧬 An exciting contribution to our understanding of cytoskeletal dynamics.📖 Read the full article here: www.nature.com/articles/s41...
Registration is now open for the 4th Structural Biology Symposium.
Poster abstract submission is due on 4/15/2025. isb.med.upenn.edu/4th-structur...
🧬@Structuralbiology
Emily Whitehead and her father on CNN with Jake Tapper speaking to the value of science. She is alive thanks to CAR T therapy developed at Penn and CHOP.
A group of smiling women posing in front of Philadelphia city hall with a sign that reads “science not silence”.
A women at Philadelphia city hall with her face partially obscured by a sign that reads “science not silence”.
A pair of smiling women posing at Philadelphia city hall with a sign that reads “science not silence”.
Pharmacology 💊 women in STEM 👩🏻🔬 showed up & out for scientific funding! 🧬
#standupforscience2025
#standupforsciencephilly
Philadelphia Stand Up For Science! #standupforscience2025
Friday, March 7 · 11am - 1pm
Philadelphia City Hall
standupforscience2025.org
