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B lymphocyte protein factories produced by hematopoietic stem cell gene editing | Science www.science.org/doi/10.1126/...
How did COVID mRNA vaccines improve favorable responses and patient outcomes for cancer immunotherapy?
www.nature.com/articles/s41...
A new report today on the priming of CD8+ T cells by these vaccines, a likely explanation
www.nature.com/articles/s41...
Here is that #paper @Nature #mRNA #vaccines engage unconventional pathways in #CD8+ #Tcell #priming #KenMurphy #SuinJo #ChandraniThakur @WashUNeurology @washumedicine www.nature.com/articles/s41...
It's #Wednesday -I am so excited to see a collaborative paper coming out as print 11AM. Its a privilege to have contributed a tiny part along with senior author who has written #immunology #textbook!
What a #fantastic day for #science and #young #minds -this is such a #great #news www.nsf.gov/news/nsf-ann...
isnt that scary and sad at the same time!
As the deadline approaching for our #offered #prospective #graduate #students to #accept our #offer -I cant explain how thrilled I am to welcome them! I know many of them accepted and they are exceptional
Thank you to @HCneuro for awarding our lab a #2025 #pilot #award to examine the role of #adaptive #immune #system in #Parkinson #Disease @WashUNeurology hopecenter.wustl.edu/funding-awar...
Proud to be attending #Neuroinflammation in Health & Disease, this June in Whistler with @keystoneSymposia.bsky.social Looking forward to big ideas, bold science, and great conversations. keysym.us/KSNeuroInflam26 #KSNeuroInflam26
See you at the #AAIC2026 as it will be my first AD #conference presenting our work on #Adaptive #immunity #Tcells in #Alzheimer #disease @alzheimerssoc.bsky.social
Made it to THE #BRIDGE
Driving towards Edmund Pettus Bridge, #SELMA…the #heart is #heavy #martinlutherking #freedom #johnlewis
It’s hard to leave this place…..but
Here is the preprint Combined talimogene laherparepvec and binimetinib in patients with NRAS-mutated melanoma induces anti-tumor immunity www.medrxiv.org/content/10.6...
we believe that the #striking #clinical #responses compel us to report these results so that other patients might benefit from our experience
we observed unexpected responses in melanoma patients with driver mutations in HRAS, NF1, and GNAQ, indicating that exceptional responses to combined T-VEC and binimetinib may extend beyond NRAS-mutated melanoma.
#Intratumoral #CD4Tcells following combination therapy were enriched for a CXCR6+ Th1 effector subset distinct from the follicular helper (Tfh) phenotype associated with tumor-reactive CD4+ T cells
6 of 7 patients (85.7%) who received #TVEC and binimetinib therapy achieved a complete response compared to 2 of 7 (28.6%) patients with NRAS-mutated melanoma treated with T-VEC alone or combined with #checkpoint blockade agents
we find that #TVEC combined with #MEK #inhibitor #binimetinib induced exceptional clinical responses by amplification of pre-existing #Tcell responses and induction of de novo tumor-reactive immunity.
This will soon be online as #preprint. Collaboratively, our first attempt to understand #tumor #response upon #oncolytic #virus #TVEC #therapy in #melanoma by a brilliant student in our lab
We are hiring! The Brown Lab is looking for a computational biologist to join our team.
If you enjoy working with single-cell and spatial genomics data and want to study how immune cells develop and function, we’d love to hear from you!
Apply here:
hhmi.wd1.myworkdayjobs.com/External/job...
" #Immunological #knowledge" In parallel to overweight articles, Twitter and Bluesky-type publishing has appeared: short announcements that highlight a finding or advertise an article. Does this add to information overload? www.nature.com/articles/s41...
Imagine how much #revenue could have been #generated if there were no #funding #delays at #NIH www.fiercebiotech.com/research/des...
#Preprint #alert " we define developmentally programmed differences in #Tfh #differentiation and function with implications for #pediatric #vaccine #design" www.biorxiv.org/content/10.6...